... RhoA function. It has been shown that Wnt3a inhibits cardiogenic cell specification through a β-catenin-dependent pathway. On the basis of our results, we propose that Wnt3a concomitantly guides the movement of cardiac progenitors by a novel mechanism involving RhoA-dependent chemorepulsion. How...

... a zone-specific targeting of VNO axons in the AOB well before cell bodies of these neurones in the VNO acquire their final zonal position. In vitro assays show that Slit1-Slit3 chemorepel VNO axons, suggesting that basal axons are guided to the posterior AOB due to chemorepulsive activity of Slits...

... that act as their receptors. In vertebrates, Slit causes chemorepulsion of embryonic olfactory tract, spinal motor, hippocampal and retinal ganglion cell axons. Since Slits are expressed in the septum and floor plate during the period when these tissues cause chemorepulsion of olfactory tract and spinal...

...S. Alcántara; M. Ruiz; F. De Castro; E. Soriano; C. Sotelo ABSTRACT Netrin 1 is a long-range diffusible factor that exerts chemoattractive or chemorepulsive effects on developing axons growing to or away from the neural midline. Here we used tissue explants to study the action of netrin 1...

... in the establishment of appropriate axon trajectories, we have characterized a novel secreted semaphorin in grasshopper, gSema 2a. Sema 2a is expressed in a gradient in the developing limb bud epithelium during Ti pioneer axon outgrowth. We demonstrate that Sema 2a acts as chemorepulsive guidance molecule critical...

... axon patterning in the embryonic diencephalon. * Author for correspondence (e-mail: [email protected] ) 04 02 1998 11 12 1997 © 1998 by Company of Biologists 1998 Chemorepulsion Chemoattraction Epithalamus Floor plate Hypothalamus Lateral geniculate nucleus...