.... Here, we describe new roles of an uncharacterized transcript upregulated by neurogenic progenitors during mouse corticogenesis: 4931414P19Rik (hereafter named P19). Overexpression of P19 cell-extrinsically inhibited neuronal migration and acted as chemoattractant of microglial cells. Interestingly...

..., that this coordination is regulated by the expression of FGF8, which shifts posteriorly during body axis elongation. FGF8 acts as a chemoattractant on the leader cells of the elongating WD and prevents them from epithelialization, whereas static (‘rear’) cells that receive progressively less FGF8 undergo...

... migration of pontine neurons are poorly understood. Here, we report that a chemokine SDF1 (also known as CXCL12) derived from the meningeal tissue regulates the migratory pathways of PCN. PCN are chemoattracted by the meningeal tissue, an effect that is mimicked by an SDF1 source. Analysis of knockout mice...

... of the specificity of these responses is not well understood. The C. elegans FGF receptor EGL-15 similarly mediates a number of different responses, including transducing a chemoattractive signal and mediating an essential function. Analysis of the migration-specific alleles of egl-15 has identified a novel EGL-15...

... Hippocampal development Circuit formation DCC receptor Axonal navigation Chemoattraction Neural activity Hippocampal commissure Mouse Diffusible signals acting at distance, including the netrin and semaphorin families, are important cues for the early guidance of neuronal pathways. Netrin 1...

... to leave the hindbrain via large dorsal exit points. They then grow in association with sensory ganglia, to their targets, the muscles of the branchial arches. We have investigated the possibility that pathway tissues might secrete diffusible chemorepellents or chemoattractants that guide cranial motor...

...S. Alcántara; M. Ruiz; F. De Castro; E. Soriano; C. Sotelo ABSTRACT Netrin 1 is a long-range diffusible factor that exerts chemoattractive or chemorepulsive effects on developing axons growing to or away from the neural midline. Here we used tissue explants to study the action of netrin 1...

... axon patterning in the embryonic diencephalon. * Author for correspondence (e-mail: [email protected] ) 04 02 1998 11 12 1997 © 1998 by Company of Biologists 1998 Chemorepulsion Chemoattraction Epithalamus Floor plate Hypothalamus Lateral geniculate nucleus...