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Keywords: Checkpoint
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Journal Articles
Journal: Development
Development (2015) 142 (1): 62–69.
Published: 01 January 2015
... potential perturbation of the process are poorly understood. Drosophila melanogaster male germline stem cells (GSCs) possess a checkpoint, termed the centrosome orientation checkpoint (COC), that monitors correct centrosome orientation with respect to the component cells of the niche to ensure asymmetric...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (14): 2523–2534.
Published: 15 July 2012
... statement The authors declare no competing financial interests. 29 4 2012 © 2012. 2012 Cell cycle Knockout mouse Meiosis NIPA (ZC3HC1) CCNB1 Checkpoint The regulated oscillation of protein expression and degradation is an essential mechanism of cell cycle control...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (22): 3857–3866.
Published: 15 November 2010
... CRL2 components in vitro and in vivo in a BC/Cul-2 box-dependent manner. Loss of lrr-1 function causes cell cycle arrest in the mitotic region of the germ line, resulting in sterility due to the depletion of germ cells. Inactivation of the DNA replication checkpoint signaling components ATL-1 and CHK-1...
Journal Articles
Journal: Development
Development (2008) 135 (9): 1647–1657.
Published: 01 May 2008
... in cycle times indicates that regulation of the cycle manifests at a single random transition in G2, and we present the first identified checkpoint in Dictyostelium , which operates at the G2-M transition in response to DNA damage. * Author for correspondence (e-mail: j.chubb@dundee.ac.uk ) 4 3...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (7): 1247–1257.
Published: 01 April 2008
... telangiectasia mutated(ATM), Checkpoint kinase 2 (Chk2) and the tumor suppressor p53. We found that the apoptosis induced by the prim1 mutation depends on the ATM-Chk2-p53 apoptotic pathway. These data suggest that the surveillance system of genome integrity strongly influences the cell fate decision between...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (20): 4509–4520.
Published: 15 October 2005
...Daniel Pérez-Mongiovi; Nicolas Malmanche; Hassan Bousbaa; Claudio Sunkel The spindle checkpoint is a surveillance mechanism that regulates the metaphase-anaphase transition during somatic cell division through inhibition of the APC/C ensuring proper chromosome segregation. We show...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (11): 2565–2575.
Published: 01 June 2004
... induced by RNAi. The frequency of these defects was accentuated by γ-irradiation, implying that they were derived from spontaneous or induced DNA damage. wrn-1 (RNAi) worms showed accelerated larval growth irrespective of γ-irradiation, and pre-meiotic germ cells had an abnormal checkpoint response to DNA...
Journal Articles
Journal: Development
Development (2003) 130 (24): 5975–5987.
Published: 15 December 2003
... ) * These authors contributed equally to this work 27 8 2003 © 2003. 2003 Chromatin Male sterility Checkpoint Cohesion Synapsis Table 2. Segregation of the duet phenotype Wild type:mutant Observed Expected χ 2 194:51 183.75:61.25 (3:1) * 2.18, P >0.1...