... by inhibiting apoptosis. Oogenesis Apoptosis Frazzled DCC Netrin Checkpoint Drosophila National Institutes of Health T32 HD083185 NSF IOS-1853719 R35 NS097340 K12 GM081259 Netrin and its receptor Deleted in colorectal cancer (Dcc, Frazzled in Drosophila ) play crucial...

... potential perturbation of the process are poorly understood. Drosophila melanogaster male germline stem cells (GSCs) possess a checkpoint, termed the centrosome orientation checkpoint (COC), that monitors correct centrosome orientation with respect to the component cells of the niche to ensure asymmetric...

... statement The authors declare no competing financial interests. 29 4 2012 © 2012. 2012 Cell cycle Knockout mouse Meiosis NIPA (ZC3HC1) CCNB1 Checkpoint The regulated oscillation of protein expression and degradation is an essential mechanism of cell cycle control...

... CRL2 components in vitro and in vivo in a BC/Cul-2 box-dependent manner. Loss of lrr-1 function causes cell cycle arrest in the mitotic region of the germ line, resulting in sterility due to the depletion of germ cells. Inactivation of the DNA replication checkpoint signaling components ATL-1 and CHK-1...

... in cycle times indicates that regulation of the cycle manifests at a single random transition in G2, and we present the first identified checkpoint in Dictyostelium , which operates at the G2-M transition in response to DNA damage. It is unclear whether Dictyostelium cells replicate their nuclear DNA...

... telangiectasia mutated(ATM), Checkpoint kinase 2 (Chk2) and the tumor suppressor p53. We found that the apoptosis induced by the prim1 mutation depends on the ATM-Chk2-p53 apoptotic pathway. These data suggest that the surveillance system of genome integrity strongly influences the cell fate decision between...

...Daniel Pérez-Mongiovi; Nicolas Malmanche; Hassan Bousbaa; Claudio Sunkel The spindle checkpoint is a surveillance mechanism that regulates the metaphase-anaphase transition during somatic cell division through inhibition of the APC/C ensuring proper chromosome segregation. We show...

... induced by RNAi. The frequency of these defects was accentuated by γ-irradiation, implying that they were derived from spontaneous or induced DNA damage. wrn-1 (RNAi) worms showed accelerated larval growth irrespective of γ-irradiation, and pre-meiotic germ cells had an abnormal checkpoint response to DNA...

... ) * These authors contributed equally to this work 27 8 2003 © 2003. 2003 Chromatin Male sterility Checkpoint Cohesion Synapsis Meiosis in plants is the transition between the diploid sporophyte and haploid gametophyte generations which in lower plants exist as distinct free-living...

...Shigeo Hayashi ABSTRACT DNA replication in G2 does not normally occur due to the checkpoint control. To elucidate its mechanism, the functions of the escargot and Dmcdc2 genes of Drosophila were studied. When escargot function was eliminated, diploid imaginal cells that were arrested in G2 lost...

... Drosophila melanogaster embryogenesis cell cycle checkpoint cytoskeleton microtubule midbody In Drosophila , and many other higher eukaryotes, the initial embryonic divisions are synchronous, exhibit highly abbreviated G1 and G2 stages, and occur without cell growth. Drosophila has proved...