...Jennifer K. Ocasio; Rolf Dale P. Bates; Carolyn D. Rapp; Timothy R. Gershon ABSTRACT Cerebellar development requires regulated proliferation of cerebellar granule neuron progenitors (CGNPs). Inadequate CGNP proliferation causes cerebellar hypoplasia whereas excessive CGNP proliferation can cause...

...), raising questions regarding its role as a regulator of neural progenitor cell cycle progression in cerebellar development. To characterize in vivo the function of ZFP423 in neurogenesis, we analyzed allelic murine mutants in which distinct functional domains are deleted. One deletion impairs mitotic...

... Pals1 mutants show defects in cerebellar organogenesis, with disrupted laminar organisation and impaired proliferation of cerebellar progenitors. Cerebellar development Pals1 Mpp5 Polarity complex proteins Germinal zones Mouse Bergmann glia A mature cerebellum includes Purkinje...

... to their mature location in the inner granule layer. In this study, we examined the expression of D type cyclins in GNPs during cerebellar development and showed that GNPs in early development expressed only cyclin D1, whereas later GNPs expressed both cyclins D1 and D2. Coinciding with the period of cyclin D1...

... development. * Author for correspondence (e-mail: [email protected] ) 5 5 2005 ©2005. 2005 PTEN Bergmann glia Cerebellar development Mouse Precise neuronal functions require highly ordered cell proliferation,differentiation, migration and synaptic specificity...

... of the Purkinje cells occurs within the ventricular zone during the early phases of cerebellar development,Purkinje cell precursors migrate to form the first cell layer and thereby set up the framework for the cerebellar cortex. Concomitantly, granule cell precursors appear in an area of the neuroepithelium...

...; and (5) loss of Rb deficient CNS precursor cells is mediated by p53-independent apoptosis. * Author for correspondence (e-mail: [email protected] ) 16 4 2003 © 2003. 2003 Cre-LoxP system Cerebellar development Rb Engrailed-2 p107 Granule cell Purkinje cell Mouse...

... that precise spatio-temporal regulation of TAG-1 and F3/contactin expression is critical for normal cerebellar morphogenesis. † Authors for correspondence (e-mail: [email protected] and [email protected] ) 3 10 2002 © 2003. 2003 Cerebellar development Neurite growth...

... disruption of two negative regulators of Rac, Abr and Bcr , in mice leads to specific abnormalities in postnatal cerebellar development. Mutants exhibit granule cell ectopia concomitant with foliation defects. We provide evidence that this phenotype is causally related to functional and structural...

... for the appropriate balance of transcriptional activators and repressors during postnatal cerebellar development. * These two authors contributed equally to this work ‡ Authors for correspondence (e-mail: [email protected] ; and [email protected] ) 07 03 2000 10 01 2000 ©...