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Keywords: Centrosome
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Journal Articles
Journal: Development
Development dev.199997.
Published: 10 January 2022
... 12 2021 © 2022. Published by The Company of Biologists Ltd 2022 http://www.biologists.com/user-licence-1-1/ Centrosome Cytoskeleton Force chains Packing Ex vivo Microtubules Syncytium Human Frontier Science Program https://dx.doi.org/10.13039/501100000854 RGY0083...
Journal Articles
Journal: Development
Development (2021) 148 (20): dev198416.
Published: 19 October 2021
... that the centrosomal recruitment of PCMD-1 is dependent on the outer centriolar protein SAS-7. The most C-terminal part of PCMD-1 is sufficient to target it to the centrosome, and the coiled-coil domain promotes its accumulation by facilitating self-interaction. We reveal that PCMD-1 interacts with the PCM scaffold...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (8): dev197558.
Published: 16 April 2021
... have identified protease serine 50 (PRSS50) as having a crucial role in sperm development, because Prss50 -null mice presented with impaired fertility and sperm tail abnormalities. PRSS50 could also be involved in centrosome function because these mice showed a threefold increase in acephalic sperm...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (22): dev183053.
Published: 18 November 2019
.... Drosophila Male meiosis Centrosome Cytokinesis Spermatogenesis Spermatogenesis in Drosophila melanogaster offers a well-suited model system in which to investigate how transcriptional and post-transcriptional mechanisms of gene regulation coordinate cell cycle progression with cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (21): dev170613.
Published: 06 November 2018
.... This includes regulation of both the spatial distribution of mitosis and the mode of cell division. The centrosome, which is the main microtubule-organizing centre of animal cells, contributes to both of these processes. Here, we discuss the impact that centrosome-mediated control of cell division has...
Journal Articles
Journal: Development
Development (2017) 144 (17): 3012–3021.
Published: 01 September 2017
... differentiated cells regulate microtubule geometry in vivo . References Abal , M. , Piel , M. , Bouckson-Castaing , V. , Mogensen , M. , Sibarita , J. B. and Bornens , M. ( 2002 ). Microtubule release from the centrosome in migrating cells . J. Cell Biol.   159 , 731 - 737...
Journal Articles
Journal: Development
Development (2016) 143 (9): 1491–1501.
Published: 01 May 2016
...Sharda Prasad Yadav; Neel Kamal Sharma; Chunqiao Liu; Lijin Dong; Tiansen Li; Anand Swaroop ABSTRACT Defects in cilia centrosomal genes cause pleiotropic clinical phenotypes, collectively called ciliopathies. Cilia biogenesis is initiated by the interaction of positive and negative regulators...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (1): 62–69.
Published: 01 January 2015
... potential perturbation of the process are poorly understood. Drosophila melanogaster male germline stem cells (GSCs) possess a checkpoint, termed the centrosome orientation checkpoint (COC), that monitors correct centrosome orientation with respect to the component cells of the niche to ensure asymmetric...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (18): 3551–3560.
Published: 15 September 2014
... by mis-segregated chromosomes, we fixed 58% of cells at a perfect 2:1:1 segregation and allowed the other 42% of cells to mis-segregate up to four chromatids. This was based on our observation that 42% wild-type papillar cells with extra centrosomes exhibited lagging/bridging DNA ( supplementary material...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (13): 2657–2668.
Published: 01 July 2013
...Bertrand Jauffred; Flora Llense; Bernhard Sommer; Zhimin Wang; Charlotte Martin; Yohanns Bellaiche Asymmetric cell division generates cell fate diversity during development and adult life. Recent findings have demonstrated that during stem cell divisions, the movement of centrosomes is asymmetric...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (9): 1843–1856.
Published: 01 May 2013
... ( johnstca@unm.edu ) Competing interests statement The authors declare no competing financial interests. © 2013. Published by The Company of Biologists Ltd 2013 Spindle Microtubules Oriented cell division Polarity Mitosis Centrosome All multicellular animals...
Journal Articles
Journal: Development
Development (2012) 139 (19): 3590–3599.
Published: 01 October 2012
... controlling axon formation in vivo are poorly understood. The centrosome has been implicated in multiple aspects of neuronal morphogenesis; however, its function in axon development is under debate. Conflicting results from studies of centrosome function in axonogenesis suggest that its role is context...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (3): 543–552.
Published: 01 February 2011
... between the microtubule cytoskeleton and Wnt/PCP signaling during zebrafish gastrulation. First, we assessed the location of the centrosome/microtubule organizing center (MTOC) relative to the cell nucleus and the body axes, as a marker of cell polarity. The intracellular position of MTOCs was polarized...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (23): 4039–4049.
Published: 01 December 2010
... ganglia. Knockdown of IoLR5 protein results in loss of the larval eyes, which normally develop in association with these ganglia. Segregation of this RNA to the first quartet cells does not occur if centrosomal localization is bypassed. We show that the specific inheritance of the RNA by the first quartet...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (11): 1907–1917.
Published: 01 June 2010
... number and mitotic orientation. Our findings suggest that the reduction in brain size observed in humans with mutations in CDK5RAP2 is associated with impaired centrosomal function and with changes in mitotic spindle orientation during progenitor proliferation. CDK5RAP2 Centrosome...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (4): 655–664.
Published: 15 February 2009
.... the neural tube), has a mutation in KIAA0568 . Similar phenotypes are seen in mice and in human syndromes with mutations in genes that encode centrosomal or intraflagella transport proteins. Such mutations lead to defects in primary cilia, sites where Hh signalling occurs. Here, we show that cells of talpid...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (13): 2387–2396.
Published: 01 July 2007
... to the centrosome. The overgrowth phenotype is also enhanced by a mutation in Cdc27 , which encodes a component of the anaphase-promoting complex (APC) that regulates the degradation of cyclins. No evidence for an apoptotic function of Zfrp8 was found. Based on the phenotype, genetic interactions and subcellular...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (1): 129–139.
Published: 01 January 2006
... this transport takes place. We have identified a centriole-containing centrosome close to the oocyte nucleus. Remarkably, the centrosomal components, γ-tubulin and Drosophila pericentrin-like protein also strongly accumulate at the periphery of this nucleus. MT polymerization after cold-induced disassembly...
Includes: Multimedia, Supplementary data