... embryonic development. We showed recently that the SIX1 homeoprotein, an essential regulator of organogenesis, is also a repressor of adult cellular senescence. Alterations in the SIX/EYA pathway are linked to the human branchio-oto-renal (BOR) syndrome, a rare congenital disorder associated with defects...

.... , Papalexi , E. and Satija , R. ( 2018 ). Integrating single-cell transcriptomic data across different conditions, technologies, and species . Nat. Biotechnol. 36 , 411 - 420 . 10.1038/nbt.4096 Campisi , J. ( 2011 ). Cellular senescence: putting the paradoxes in perspective...

...Hongorzul Davaapil; Jeremy P. Brockes; Maximina H. Yun Cellular senescence, a form of stable cell cycle arrest that is traditionally associated with tumour suppression, has been recently found to occur during mammalian development. Here, we show that cell senescence is an intrinsic part...