... in disparate tissues often exhibit common features, yet the general principles regulating their architecture are not known. Here, we provide a formal framework for understanding the relationship between cell molecular ‘states’ and cell ‘types’, based on the topology of admissible cell state trajectories. We...

... atlases Cell identity Cell state Single cell For centuries, biologists have sought to deconstruct the complexity of biological systems by breaking them down into their component parts – cells – and cataloging these individual units according to their identity. Establishing such a cellular...

... financial interests. 25 9 2012 © 2013. Published by The Company of Biologists Ltd RNA visualization Cell state Differentiation Fluorescent in situ hybridization Single cell Single molecule The primary unit of biological control is the cell. Measurement...