..., shape and patterned gene expression in an organoid model of mammalian gastrulation. Gastruloid Morphogenesis Cell signaling National Science Foundation http://dx.doi.org/10.13039/100000001 1750663 2134935 Embryos undergo both dramatic physical transformations and complex...

... signaling. FGF Cell signaling Branching morphogenesis Salivary gland Basement membrane National Institute of Dental and Craniofacial Research http://dx.doi.org/10.13039/100000072 DE022778 The submandibular and the sublingual glands (SMG and SLG) regulate most of the saliva...

... neighboring cells, or into the circulation to impact distant cells. On target cells, these signals interact with receptors to activate cell signaling pathways, triggering an intracellular response. The coordinated activation of cell signaling pathways in multiple tissues and organs supports development...

.../100000001 IOS-1238051 Cell signaling Cytokinin Plant development Plant hormones Summary: Disrupting a subset of histidine kinase (HK) genes in Oryza sativa reveals that HK5 and HK6 act as cytokinin receptors with overlapping functions to regulate diverse aspects of rice growth...

... pathway components, is a component of the Notch-Su(H) activation complex and positively regulates Notch signaling. Cell signaling Notch Activation complex Enhancer of Split complex Chromo-domain Hat-trick Drosophila Notch signaling is an evolutionarily conserved pathway...

..., rinsed with PBS and permeabilized with 0.5% Triton-X for 5 min. Primary myoblasts were then blocked with 1% BSA in PBS for 30 min before addition of antibodies. Rabbit anti-β-catenin (9562, Cell Signaling Technology), mouse anti-myogenin (F5D-c, DSHB) or anti-MyHC (MF-20-c, DSHB) antibodies were applied...

.... Published by The Company of Biologists Ltd 2018 Cytokinin Plant hormones Cell signaling Two-component signaling Cytokinins were discovered in a search for factors that promote cell proliferation in cultured plant cells in concert with a second phytohormone, auxin. This search resulted...

... collection of 165 Drosophila miRNA transgenes and find that a majority induced specific developmental defects, including phenocopies of mutants in myriad cell-signaling and patterning genes. Such connections allowed us to validate several likely targets for miRNA-induced phenotypes. Importantly, few...

...-dependent cell-cell signaling. These findings indicate that Crb acts as a cell-contact-dependent receptor that regulates growth by modulating Hippo pathway activity. The Drosophila Crumbs (Crb) protein was recently added to the Hippo pathway as a potential new receptor ( Chen et al., 2010 ; Ling et...

... and Albertson, 2008 ; Oates et al., 2009 ). Although these results specifically address the relationship of SHH-signaling strength to midfacial growth and shape, this approach can be applied to other related cell-signaling pathways (e.g. BMP, WNT, FGF, etc.) and anatomical structures (e.g. the autopod). Future...

... Cell signaling Heart development Second heart field Mouse model Congenital heart disease (CHD) represents the most common birth defect in humans, affecting nearly 1% of newborns. Since more than 30% of CHD patients have outflow tract (OFT) defects ( Rosamond et al., 2007 ), understanding how...

.... Cell. Biol. 20 , 2400 -2410. 15 6 2008 © 2008. 2008 Drosophila Cell signaling Feedback modulation Transcriptional repression A limited number of intercellular signaling pathways are used reiteratively in different contexts to control the development of metazoans...

... demonstrates how complex patterns of gene expression can emerge from simple inputs, through the interaction of regulatory network motifs. Cell signaling Epithelial patterning Feedforward control Pattern formation Drosophila Pattern formation in development relies on combinatorial interactions...

...-mail: nakamura@idac.tohoku.ac.jp ) * Present address: Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA 28 5 2004 © 2004. 2004 Tectum Cerebellum Fgf8 Isthmus Cell signaling Ras ERK Chick...

...), Xenopus (Xen-chh, Q91610 and Xen-hh4, Q91611) and another zebrafish gene (Dan-ehh, Q98862). See text for details. ‡ Author for correspondence (e-mail: weisblat@uclink4.berkeley.edu ) 17 1 2003 © 2003. 2003 hedgehog Helobdella robusta Gut formation Cell signaling...

...-mail: brand@mpi-cbg.de ) 8 4 2002 © 2002. 2002 Pax Transgenesis no isthmus Fgf8 engrailed Zebrafish Danio rerio Cell signaling CNS Midbrain Hindbrain Isthmus Organizer Pattern formation During pattern formation in vertebrate neural development regional gene...

... proliferation, along a putative line running in an anterior to posterior direction just dorsal to the limb buds ( Balinsky, 1950 ; Propper, 1978 ). Fgf10 Fgfr2b Lef1 Mammary placode development Mouse Cell signaling © 2002. 2002 5 10 2001 †Author for correspondence (e...

... 100 , 399 -409. 4 6 2001 ©2001. 2001 Neurogenesis Slit Roundabout Cell signaling Ganglion mother cells Asymmetric division Drosophila melanogaster In both insects and vertebrates, midline cells play a key role in the formation of the axon commissures...

... Heidelberg, Germany 13 11 2000 11 01 2001 © 2001 by Company of Biologists 2001 Pituitary Organogenesis Boundary Sonic hedgehog Hip Cell signaling Mouse The pituitary gland originates through the interaction of two different ectodermal tissues, the neural and oral...

... Integrin Differentiation Egfr Cell signaling How do cells in different tissues interact? Cells can interact with each other either directly or via the extracellular matrix (ECM). The ECM is composed of a variety of proteins and polysaccharides in a fibrous meshwork, closely associated...