... describe how the pattern is sharpened and stabilised through the dynamic regulation of cell identity, acting in parallel with cell segregation. Finally, we discuss evidence that boundary cells have roles in local patterning, and act as a site of neurogenesis within the hindbrain. References Addison...

... segment-specific cell fates. It has been unclear, however, whether Hox proteins drive the epithelial cell segregation mechanism that is thought to initiate the segmentation process. Here, we investigate the role of vertebrate Hox proteins during the partitioning of the developing hindbrain into lineage...

... Paris Cedex 15, France 07 10 1999 08 12 1999 © 1999 by Company of Biologists 1999 Krox-20 Nab1 Nab2 Transcriptional repression Hindbrain development Rhombomere identity Cell segregation The development of the vertebrate hindbrain involves a transient...

... regional identity and segregation target genes ( Seitanidou et al., 1997 ; Schneider-Maunoury et al., 1998). In this respect, this mechanism would link proximity to r4, cell proliferation, specification of identity and cell segregation through the multiple functions of Krox-20. It is interesting to note...