... is associated with the plasma membrane and plasmodesmata within the root apical meristem (RAM). Loss of ATM1 function results in decreased RAM size and reduced cell proliferation in a sugar-dependent manner. Auxin signaling and transcriptional responses were dampened in atm1-1 roots. Complementation of atm1-1...

... polarized cell shapes and oriented motility, with emigration from the thorax and subsequent dispersal to the abdomen and head. After the migration period, these cells adhered to each other, assembling into the AFB with a sheet-like architecture. Continuous cell proliferation occurred during and after...

... of the lung in addition to controlling expression of multiple cell cycle regulators. Alveolar development Transcriptional regulation Cell proliferation Lung mesenchyme Lipofibroblast Myofibroblast National Institutes of Health HL126703 UL1TR001442 HL086324 National Heart...

.... , Lefevre , C. , Goupille , O. , Penglong , T. , Granger-Locatelli , M. , Fucharoen , S. , Maouche-Chretien , L. , Leboulch , P. and Chretien , S. ( 2015 ). Erythropoietin and IGF-1 signaling synchronize cell proliferation and maturation during erythropoiesis . Genes Dev...

...-related damage to the intestinal epithelium ( Regan et al., 2016 ) and increased susceptibility to genetically induced tumors ( Ahmed et al., 2020 ; Hudry et al., 2016 ). A sex difference in stem cell proliferation therefore not only has important consequences for normal physiology, but also influences...

... development. Here, we show that Ror2-mediated non-canonical Wnt signaling in the dental mesenchyme plays a crucial role in cell proliferation, and thereby regulates root development size in mouse molars. Furthermore, Cdc42 acts as a potential downstream mediator of Ror2 signaling in root formation...

... with experimentally measured parameters to simulate embryonic tail bending. Actomyosin asymmetrically accumulated at the ventral side of the notochord, and cell proliferation of the dorsal tail epidermis was faster than that in the ventral counterpart during embryonic tail bending. Genetic disruption of actomyosin...

... regeneration and/or disease progression would provide valuable information on these processes. Here, we report a new genetic system that allows cell proliferation to be inhibited in a tissue-specific manner. We generated Cre- or Dre-inducible p21-GFP (ip21-GFP) transgenic mice that enable experimentally...

...Tünde Leviczky; Eszter Molnár; Csaba Papdi; Erika Őszi; Gábor V. Horváth; Csaba Vizler; Viktór Nagy; János Pauk; László Bögre; Zoltán Magyar ABSTRACT The E2F transcription factors and the RETINOBLASTOMA-RELATED repressor protein are principal regulators coordinating cell proliferation...

... and TLR8 in the nervous system is dynamic during development, so both might function in nervous system development ( Okun et al., 2011 ). Potential functions of Tolls in cell proliferation have not been explored in Drosophila and, conversely, the ligands and mechanisms mediating TLR function in neuronal...

..., and analyzed the biological activities of phosphomimetic (4E) and nonphosphorylatable (4A) mutants for those sites. In the neuroectoderm, the 4E but not the 4A mutant downregulated the Cdk inhibitor gene p27xic1 ( cdknx ) and posterior genes, and promoted cell proliferation, possibly forming a positive...

...)-mediated TE polarity in mammalian embryos. Mechanistically, CDX2 -depleted porcine embryos stalled at the blastocyst stage and exhibited apoptosis and inactive cell proliferation, possibly resulting from BMP4 downregulation. Moreover, TE cells in CDX2 -depleted blastocysts displayed defective F-actin...

... models. Heart regeneration Cardiomyocyte Cell proliferation p53 Lineage tracing Mouse Pathological cardiac insults, such as myocardial infarction, cause irreversible cardiac remolding, myocardial fibrosis and impaired heart function, eventually leading to heart failure. For a long...

... + channels establish a balance between cell proliferation and barrier properties in the neuroepithelium that lines the ventricles during development of the zebrafish brain ventricular system. Kcng4b Kcnb1 Neuroependyma extrusion Hydrocephalus Cell proliferation Tissue integrity Zebrafish...

...: Chemical treatments combined with live imaging reveal that re-epithelialization of zebrafish wounds utilizes TGFβ/integrin-dependent active keratinocyte crawling as well as epidermal rearrangements. FGF Re-epithelialization Skin TGF-β Wound healing Cell proliferation The epidermis, which...

...Carrie M. Spratford; Justin P. Kumar ABSTRACT During development, the rate of cell proliferation must be constantly monitored so that an individual tissue achieves its correct size. Mutations in genes that normally promote tissue growth often result in undersized, disorganized and non-functional...

... component of CLV3/CLE signaling in the RM. Mutations in PUB4 reduced the inhibitory effect of exogenous CLV3/CLE peptide on root cell proliferation and columella stem cell maintenance. Moreover, pub4 mutants grown without exogenous CLV3/CLE peptide exhibited characteristic phenotypes in the RM...

...Anneke Horstman; Hiroyuki Fukuoka; Jose M. Muino; Lisette Nitsch; Changhua Guo; Paul Passarinho; Gabino Sanchez-Perez; Richard Immink; Gerco Angenent; Kim Boutilier AINTEGUMENTA-LIKE (AIL) transcription factors are key regulators of cell proliferation and meristem identity. Although AIL functions...

... of Biologists Ltd 2013 Heart regeneration Chemical screen Cardiomyocyte Cell proliferation Epicardium Endocardium Zebrafish A fundamental cellular block to heart regeneration in adult mammals is the low capacity of mature mammalian cardiomyocytes to undergo proliferation after injury...

... genes such as cut, Lim1 and wingless . Instead of undergoing apoptosis, a population of mutant retinal progenitors and precursor cells adopt a head capsule fate. This transformation is accompanied by an adjustment of cell proliferation rates such that just enough head capsule is generated to produce...