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Keywords: Cell proliferation
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Journal Articles
Journal: Development
Development (2021) 148 (19): dev199750.
Published: 14 October 2021
... molecular, cellular, organ-level and organismal mechanisms. Sex difference Cell death Cell proliferation Stem cell Organ homeostasis Cell signaling Canadian Institutes for Health Research PJT-153072 GS4-171365 Natural Sciences and Engineering Research Council of Canada...
Journal Articles
Journal: Development
Development (2021) 148 (2): dev196360.
Published: 21 January 2021
... development. Here, we show that Ror2-mediated non-canonical Wnt signaling in the dental mesenchyme plays a crucial role in cell proliferation, and thereby regulates root development size in mouse molars. Furthermore, Cdc42 acts as a potential downstream mediator of Ror2 signaling in root formation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (24): dev185868.
Published: 23 December 2020
... with experimentally measured parameters to simulate embryonic tail bending. Actomyosin asymmetrically accumulated at the ventral side of the notochord, and cell proliferation of the dorsal tail epidermis was faster than that in the ventral counterpart during embryonic tail bending. Genetic disruption of actomyosin...
Journal Articles
Journal: Development
Development (2020) 147 (4): dev183830.
Published: 17 February 2020
... regeneration and/or disease progression would provide valuable information on these processes. Here, we report a new genetic system that allows cell proliferation to be inhibited in a tissue-specific manner. We generated Cre- or Dre-inducible p21-GFP (ip21-GFP) transgenic mice that enable experimentally...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2019) 146 (22): dev179333.
Published: 26 November 2019
...Tünde Leviczky; Eszter Molnár; Csaba Papdi; Erika Őszi; Gábor V. Horváth; Csaba Vizler; Viktór Nagy; János Pauk; László Bögre; Zoltán Magyar ABSTRACT The E2F transcription factors and the RETINOBLASTOMA-RELATED repressor protein are principal regulators coordinating cell proliferation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (9): dev156018.
Published: 25 April 2018
... functions of Tolls in cell proliferation have not been explored in Drosophila and, conversely, the ligands and mechanisms mediating TLR function in neuronal number control in mammals are unknown. Changes in neuronal and glial number, neurite growth and retraction, and synapse formation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (5): dev159640.
Published: 12 March 2018
..., and analyzed the biological activities of phosphomimetic (4E) and nonphosphorylatable (4A) mutants for those sites. In the neuroectoderm, the 4E but not the 4A mutant downregulated the Cdk inhibitor gene p27xic1 ( cdknx ) and posterior genes, and promoted cell proliferation, possibly forming a positive...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (7): 1296–1306.
Published: 1 April 2017
...)-mediated TE polarity in mammalian embryos. Mechanistically, CDX2 -depleted porcine embryos stalled at the blastocyst stage and exhibited apoptosis and inactive cell proliferation, possibly resulting from BMP4 downregulation. Moreover, TE cells in CDX2 -depleted blastocysts displayed defective F-actin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (4): 580–589.
Published: 15 February 2017
... that multinucleation was minor at this stage. Therefore, detection of Ki-67, a well-established nuclear marker for cell proliferation, can reveal cardiomyocyte cycling during this stage. Our previous study indicates that the p53 reporter could serve as a surrogate marker for cell proliferation in murine tissues...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (22): 4249–4260.
Published: 15 November 2016
... + channels establish a balance between cell proliferation and barrier properties in the neuroepithelium that lines the ventricles during development of the zebrafish brain ventricular system. Kcng4b Kcnb1 Neuroependyma extrusion Hydrocephalus Cell proliferation Tissue integrity Zebrafish...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (12): 2077–2088.
Published: 15 June 2016
...: Chemical treatments combined with live imaging reveal that re-epithelialization of zebrafish wounds utilizes TGFβ/integrin-dependent active keratinocyte crawling as well as epidermal rearrangements. FGF Re-epithelialization Skin TGF-β Wound healing Cell proliferation The epidermis, which...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (11): 2058–2068.
Published: 1 June 2015
...Carrie M. Spratford; Justin P. Kumar ABSTRACT During development, the rate of cell proliferation must be constantly monitored so that an individual tissue achieves its correct size. Mutations in genes that normally promote tissue growth often result in undersized, disorganized and non-functional...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (3): 444–453.
Published: 1 February 2015
... component of CLV3/CLE signaling in the RM. Mutations in PUB4 reduced the inhibitory effect of exogenous CLV3/CLE peptide on root cell proliferation and columella stem cell maintenance. Moreover, pub4 mutants grown without exogenous CLV3/CLE peptide exhibited characteristic phenotypes in the RM...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (3): 454–464.
Published: 1 February 2015
...Anneke Horstman; Hiroyuki Fukuoka; Jose M. Muino; Lisette Nitsch; Changhua Guo; Paul Passarinho; Gabino Sanchez-Perez; Richard Immink; Gerco Angenent; Kim Boutilier AINTEGUMENTA-LIKE (AIL) transcription factors are key regulators of cell proliferation and meristem identity. Although AIL functions...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (3): 660–666.
Published: 1 February 2013
... monitors cardiomyocyte proliferation in live zebrafish embryos. FUCCI technology enables the visualization of cell proliferation events in live animals. Here, we developed a FUCCI-based screening system that identified modulators of adult heart regeneration, including compounds that augment...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (1): 205–215.
Published: 1 January 2013
... genes such as cut, Lim1 and wingless . Instead of undergoing apoptosis, a population of mutant retinal progenitors and precursor cells adopt a head capsule fate. This transformation is accompanied by an adjustment of cell proliferation rates such that just enough head capsule is generated to produce...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (9): 1568–1576.
Published: 1 May 2012
... a reduction in cell proliferation. Furthermore, we present evidence that STU serves as an important regulator mediating the control of cell proliferation by GA possibly through two cyclin-dependent kinase inhibitors, SIM and SMR1 . Taken together, our results suggest that STU acts downstream of RGA...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (4): 749–759.
Published: 15 February 2012
.... Taken together, these results suggest that Jmjd5 physiologically moderates embryonic cell proliferation through the epigenetic control of Cdkn1a expression. * Author for correspondence ( suzuki-t@staff.kanazawa-u.ac.jp ) Competing interests statement The authors declare no competing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (24): 5379–5391.
Published: 15 December 2011
... signalling in neural recruitment during formation of Drosophila chordotonal sense organ clusters . Curr. Biol. 7 , 166 – 175 . Drosophila Cell proliferation Cell survival Hematopoietic colonization Hematopoiesis Hemocyte Larva Microenvironment Peripheral nervous system...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (5): 839–848.
Published: 1 March 2011
...@technion.ac.il ) Competing interests statement The authors declare no competing financial interests. 14 12 2010 © 2011. 2011 Arabidopsis Brassinosteroids Growth Cell proliferation Cell-cell communication The control of final cell and organ size is a fundamental question...
Includes: Supplementary data