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Keywords: Cell proliferation
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Journal Articles
Journal: Development
Development (2021) 148 (2): dev196360.
Published: 21 January 2021
... development. Here, we show that Ror2-mediated non-canonical Wnt signaling in the dental mesenchyme plays a crucial role in cell proliferation, and thereby regulates root development size in mouse molars. Furthermore, Cdc42 acts as a potential downstream mediator of Ror2 signaling in root formation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (24): dev185868.
Published: 23 December 2020
... experimentally measured parameters to simulate embryonic tail bending. Actomyosin asymmetrically accumulated at the ventral side of the notochord, and cell proliferation of the dorsal tail epidermis was faster than that in the ventral counterpart during embryonic tail bending. Genetic disruption of actomyosin...
Journal Articles
Journal: Development
Development (2020) 147 (4): dev183830.
Published: 17 February 2020
... regeneration and/or disease progression would provide valuable information on these processes. Here, we report a new genetic system that allows cell proliferation to be inhibited in a tissue-specific manner. We generated Cre- or Dre-inducible p21-GFP (ip21-GFP) transgenic mice that enable experimentally...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2019) 146 (22): dev179333.
Published: 26 November 2019
...Tünde Leviczky; Eszter Molnár; Csaba Papdi; Erika Őszi; Gábor V. Horváth; Csaba Vizler; Viktór Nagy; János Pauk; László Bögre; Zoltán Magyar ABSTRACT The E2F transcription factors and the RETINOBLASTOMA-RELATED repressor protein are principal regulators coordinating cell proliferation with...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (9): dev156018.
Published: 25 April 2018
... differentiation in mammals ( Okun et al., 2011 ). In mice, TLRs function in neural progenitor cells (NPCs) to regulate cell proliferation and neuronal versus glial (astrocyte) cell fate determination ( Lathia et al., 2008 ; Okun et al., 2010b ; Rolls et al., 2007 ; Shechter et al., 2008 ; Sloane et al., 2010...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (5): dev159640.
Published: 12 March 2018
... analyzed the biological activities of phosphomimetic (4E) and nonphosphorylatable (4A) mutants for those sites. In the neuroectoderm, the 4E but not the 4A mutant downregulated the Cdk inhibitor gene p27xic1 ( cdknx ) and posterior genes, and promoted cell proliferation, possibly forming a positive...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (7): 1296–1306.
Published: 01 April 2017
... (PKC)-mediated TE polarity in mammalian embryos. Mechanistically, CDX2 -depleted porcine embryos stalled at the blastocyst stage and exhibited apoptosis and inactive cell proliferation, possibly resulting from BMP4 downregulation. Moreover, TE cells in CDX2 -depleted blastocysts displayed defective F...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (4): 580–589.
Published: 15 February 2017
... different injury models. Heart regeneration Cardiomyocyte Cell proliferation p53 Lineage tracing Mouse We and others observed active cardiomyocyte proliferation in the first few days after birth ( Fig. S1A-N ) ( Alkass et al., 2015 ; Senyo et al., 2013 ). We also examined the number of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (22): 4249–4260.
Published: 15 November 2016
... + channels establish a balance between cell proliferation and barrier properties in the neuroepithelium that lines the ventricles during development of the zebrafish brain ventricular system. References Aprea , J. and Calegari , F. ( 2012 ). Bioelectric state and cell cycle control of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (12): 2077–2088.
Published: 15 June 2016
... had recovered to its normal thickness at 72 hpw ( Fig. 5 B,C). Analysis of BrdU incorporation demonstrated an absence of cell proliferation within the wound epidermis during the first 24 hpw, when re-epithelialization occurs ( Fig. 5 D), and rather moderate labelling at 48 and 72 hpw ( Fig. 5 E,F). By...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (11): 2058–2068.
Published: 01 June 2015
...Carrie M. Spratford; Justin P. Kumar ABSTRACT During development, the rate of cell proliferation must be constantly monitored so that an individual tissue achieves its correct size. Mutations in genes that normally promote tissue growth often result in undersized, disorganized and non-functional...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (3): 444–453.
Published: 01 February 2015
... component of CLV3/CLE signaling in the RM. Mutations in PUB4 reduced the inhibitory effect of exogenous CLV3/CLE peptide on root cell proliferation and columella stem cell maintenance. Moreover, pub4 mutants grown without exogenous CLV3/CLE peptide exhibited characteristic phenotypes in the RM, such as...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (3): 454–464.
Published: 01 February 2015
...Anneke Horstman; Hiroyuki Fukuoka; Jose M. Muino; Lisette Nitsch; Changhua Guo; Paul Passarinho; Gabino Sanchez-Perez; Richard Immink; Gerco Angenent; Kim Boutilier AINTEGUMENTA-LIKE (AIL) transcription factors are key regulators of cell proliferation and meristem identity. Although AIL functions...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (3): 660–666.
Published: 01 February 2013
... regeneration Chemical screen Cardiomyocyte Cell proliferation Epicardium Endocardium Zebrafish A fundamental cellular block to heart regeneration in adult mammals is the low capacity of mature mammalian cardiomyocytes to undergo proliferation after injury. Several studies support the notion that...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (1): 205–215.
Published: 01 January 2013
... genes such as cut, Lim1 and wingless . Instead of undergoing apoptosis, a population of mutant retinal progenitors and precursor cells adopt a head capsule fate. This transformation is accompanied by an adjustment of cell proliferation rates such that just enough head capsule is generated to produce an...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (9): 1568–1576.
Published: 01 May 2012
... results from a reduction in cell proliferation. Furthermore, we present evidence that STU serves as an important regulator mediating the control of cell proliferation by GA possibly through two cyclin-dependent kinase inhibitors, SIM and SMR1 . Taken together, our results suggest that STU acts downstream...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (4): 749–759.
Published: 15 February 2012
.... Taken together, these results suggest that Jmjd5 physiologically moderates embryonic cell proliferation through the epigenetic control of Cdkn1a expression. * Author for correspondence ( suzuki-t@staff.kanazawa-u.ac.jp ) Competing interests statement The authors declare no competing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (24): 5379–5391.
Published: 15 December 2011
... Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan Competing interests statement The authors declare no competing financial interests. 9 9 2011 © 2011. Drosophila Cell proliferation Cell survival Hematopoietic colonization...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (5): 839–848.
Published: 01 March 2011
... Brassinosteroids Growth Cell proliferation Cell-cell communication The control of final cell and organ size is a fundamental question in the biology of all multicellular organisms. Root length is determined by the number of proliferating cells and their mature final size ( Beemster and Baskin, 1998...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (2): 349–357.
Published: 15 January 2011
... dMyc to ensure a coordinated nucleolar response to dMyc-induced growth and, thereby, normal organ development. * Authors for correspondence ( fcasfer@upo.es ; paulop@ibmc.up.pt ) Competing interests statement 1 11 2010 © 2011. Drosophila Cell proliferation Cell...
Includes: Supplementary data