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Keywords: Cell polarity
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Journal Articles
Journal: Development
Development (2021) 148 (14): dev199549.
Published: 21 July 2021
... hair bundle morphogenesis coincide with severe hearing loss in Mpdz mutants. Cell polarity Cytoskeleton Inner ear Morphogenesis Mouse genetics Sensory hair cell Mouse National Institute on Deafness and Other Communication Disorders http://dx.doi.org/10.13039/100000055...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (7): dev196956.
Published: 31 March 2021
... electrostatic PM targeting of polarity proteins in regulating cell polarity. Highlighted Article: Dlg contains a positively charged polybasic domain that electrostatically binds plasma membrane phosphoinositides, which is crucial for Dlg to regulate both polarity and tumorigenesis. Dlg Lgl Scrib...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (24): dev186346.
Published: 21 December 2020
...Marek Mlodzik ABSTRACT Planar cell polarity (PCP) reflects cellular orientation within the plane of an epithelium. PCP is crucial during many biological patterning processes and for organ function. It is omnipresent, from convergent-extension mechanisms during early development through to terminal...
Journal Articles
Journal: Development
Development (2020) 147 (19): dev191981.
Published: 05 October 2020
...Elvis Huarcaya Najarro; Jennifer Huang; Adrian Jacobo; Lee A. Quiruz; Nicolas Grillet; Alan G. Cheng ABSTRACT Planar cell polarity (PCP) proteins localize asymmetrically to instruct cell polarity within the tissue plane, with defects leading to deformities of the limbs, neural tube and inner ear...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (15): dev176529.
Published: 09 August 2019
.../ Summary: An shRNA depletion strategy has uncovered the role of Dlc in the dimerization of Egl, further revealing a step-wise assembly pathway for building a localization-competent mRNP. RNA localization Molecular motor Kinesin Cell polarity Cargo adaptor Drosophila Recent studies...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (9): dev174367.
Published: 01 May 2019
...Weiyi Xu; Anushree C. Gulvady; Gregory J. Goreczny; Eric C. Olson; Christopher E. Turner ABSTRACT Establishing apical-basal epithelial cell polarity is fundamental for mammary gland duct morphogenesis during mammalian development. While the focal adhesion adapter protein paxillin is a well...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (7): dev166819.
Published: 04 April 2019
... by the Salvador-Warts-Hippo pathway. In epithelial cells, the Hippo pathway integrates diverse biological inputs, such as cell polarity and cell-cell contacts, but Drosophila blood cells lack the conspicuous polarity of epithelial cells. Here, we show that the septate-junction components Cora and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (9): dev158444.
Published: 02 May 2018
... apical-basal polarity is remodeled and turned into front-back and inside-outside as well as apical-basal polarities, during collective migration. We find that the Crumbs (Crb) complex is required for the generation of the three distinct but interconnected cell polarities of border cells. Specifically...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2018) 145 (5): dev154617.
Published: 01 March 2018
... structures that mediate nutrient absorption and attachment to the substrate, through a mechanism that is evolutionarily conserved in land plants. Cell polarity Marchantia polymorpha NIMA-related kinase Rhizoid Tip growth Directional cell growth is essential for the development of...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2018) 145 (3): dev149336.
Published: 08 February 2018
... found in nature. In turn, this spacing relies on complex patterns of cell polarity that involve feedback between a signaling molecule – the plant hormone auxin – and its polar, cell-to-cell transport. Here, we review recent progress in understanding phyllotaxis and plant cell polarity and highlight the...
Journal Articles
Journal: Development
Development (2017) 144 (24): 4704–4719.
Published: 15 December 2017
...-cell contacts, for proper epithelial cell organization and for further differentiation of the collecting duct system. Kidney Branching morphogenesis Cell polarity Transcriptional regulation Gdnf-Gfrα1-Ret pathway Collecting duct Branching morphogenesis is the process by which...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (9): 1607–1618.
Published: 01 May 2017
... might be involved. To test this hypothesis, we conditionally deleted Numb on a Numbl mutant background just prior to gonadogenesis. Mutant gonads showed a loss of cell polarity in the surface epithelial layers, large interior cell patches expressing the undifferentiated cell marker LHX9, and a loss of...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2017) 144 (3): 499–506.
Published: 01 February 2017
...Yumiko Sakai; Shigeo S. Sugano; Takashi Kawase; Makoto Shirakawa; Yu Imai; Yusuke Kawamoto; Hiroshi Sugiyama; Tsuyoshi Nakagawa; Ikuko Hara-Nishimura; Tomoo Shimada ABSTRACT Stem cell polarization is a crucial step in asymmetric cell division, which is a universal system for generating cellular...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (14): 2508–2520.
Published: 15 July 2015
...Isabelle Roszko; Diane S. Sepich; Jason R. Jessen; Anand Chandrasekhar; Lilianna Solnica-Krezel During vertebrate gastrulation, convergence and extension movements elongate embryonic tissues anteroposteriorly and narrow them mediolaterally. Planar cell polarity (PCP) signaling is essential for...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (13): 2338–2351.
Published: 01 July 2015
... transport of a particular cargo in a spatiotemporally controlled manner. As Spn-F and Jvl are also involved in the polarized activation of IKKε during oogenesis ( Amsalem et al., 2013 ), similar mechanisms might help generate and maintain cell polarity in various cell types. As an alternative to the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (9): 1606–1615.
Published: 01 May 2015
... process regulated by cell polarity proteins, HIPPO signaling and lineage-specific transcription factors such as CDX2. However, the regulatory mechanisms that operate upstream to specify the trophectoderm lineage have not been established. Here we report that transcription factor AP-2γ (TFAP2C) functions...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (23): 4569–4579.
Published: 01 December 2014
... function of Dg was examined in Xenopus laevis embryos by knockdown of Dg and overexpression and replacement of the endogenous Dg with a mutated form of the protein. This analysis revealed that Dg is required for correct laminin assembly, for cell polarization during mediolateral intercalation and for...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (17): 3298–3302.
Published: 01 September 2014
...Jeffrey D. Axelrod; Dominique C. Bergmann A diverse group of researchers working on both plant and animal systems met at a Company of Biologists workshop to discuss ‘Coordinating Cell Polarity’. The meeting included considerable free discussion as well as presentations exploring the ways that...
Journal Articles
Journal: Development
Development (2014) 141 (10): 2119–2130.
Published: 15 May 2014
.../3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Drosophila Protein kinase Cell polarity Microtubules Dynein Here we show that mutations in drop out ( dop ) disrupt the formation of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (3): 639–649.
Published: 01 February 2014
... role in cell fate acquisition and segment boundary formation. We show that, without affecting major components of apico-basal or planar cell polarity, Hoxb1b regulates mitotic spindle rotation during the oriented neural keel symmetric mitoses that are required for normal neural tube lumen formation in...
Includes: Supplementary data