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Keywords: Cell polarity
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Journal Articles
Journal: Development
Development (2021) 148 (22): dev199935.
Published: 18 November 2021
... Institutes of Health R01GM100088 RNA localization Molecular motor Cell polarity Nanobody P body Summary: Use of proximity biotin ligation to identify components of a Dynein localization complex and the development of a nanobody-based approach to identify the interactome of any GFP...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2021) 148 (18): dev199919.
Published: 27 September 2021
... attributed. Summary: Discrete roles for cell polarity and the polarity protein BASL before and after asymmetric divisions are revealed through quantitative imaging and lineage tracking of plants expressing BASL at restricted points in the cell cycle. Stomata Asymmetric cell division Cell...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2021) 148 (17): dev199417.
Published: 9 September 2021
...Nereo Kalebic; Takashi Namba ABSTRACT Cell polarity is fundamentally important for understanding brain development. Here, we hypothesize that the inheritance and flexibility of cell polarity during neocortex development could be implicated in neocortical evolutionary expansion. Molecular...
Journal Articles
Journal: Development
Development (2021) 148 (14): dev199549.
Published: 21 July 2021
... , N. , Thiry , M. , Morelli , G. , Van Hees , L. , Laguesse , S. et al. ( 2019 ). Proteostasis is essential during cochlear development for neuron survival and hair cell polarity . EMBO Rep. 20 , e47097 . 10.15252/embr.201847097 Gao , Y. , Lui , W. , Lee...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (7): dev196956.
Published: 31 March 2021
... of electrostatic PM targeting of polarity proteins in regulating cell polarity. * These authors contributed equally to this work ‡ Author for correspondence ( yhong@pitt.edu ) Handling Editor: Thomas Lecuit Competing interests The authors declare no competing or financial interests...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (24): dev186346.
Published: 21 December 2020
...Marek Mlodzik ABSTRACT Planar cell polarity (PCP) reflects cellular orientation within the plane of an epithelium. PCP is crucial during many biological patterning processes and for organ function. It is omnipresent, from convergent-extension mechanisms during early development through to terminal...
Journal Articles
Journal: Development
Development (2020) 147 (19): dev191981.
Published: 5 October 2020
...Elvis Huarcaya Najarro; Jennifer Huang; Adrian Jacobo; Lee A. Quiruz; Nicolas Grillet; Alan G. Cheng ABSTRACT Planar cell polarity (PCP) proteins localize asymmetrically to instruct cell polarity within the tissue plane, with defects leading to deformities of the limbs, neural tube and inner ear...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (15): dev176529.
Published: 9 August 2019
.../ Summary: An shRNA depletion strategy has uncovered the role of Dlc in the dimerization of Egl, further revealing a step-wise assembly pathway for building a localization-competent mRNP. RNA localization Molecular motor Kinesin Cell polarity Cargo adaptor Drosophila Recent studies...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (9): dev174367.
Published: 1 May 2019
...Weiyi Xu; Anushree C. Gulvady; Gregory J. Goreczny; Eric C. Olson; Christopher E. Turner ABSTRACT Establishing apical-basal epithelial cell polarity is fundamental for mammary gland duct morphogenesis during mammalian development. While the focal adhesion adapter protein paxillin is a well...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (7): dev166819.
Published: 4 April 2019
... by the Salvador-Warts-Hippo pathway. In epithelial cells, the Hippo pathway integrates diverse biological inputs, such as cell polarity and cell-cell contacts, but Drosophila blood cells lack the conspicuous polarity of epithelial cells. Here, we show that the septate-junction components Cora and NrxIV promote...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (9): dev158444.
Published: 2 May 2018
... apical-basal polarity is remodeled and turned into front-back and inside-outside as well as apical-basal polarities, during collective migration. We find that the Crumbs (Crb) complex is required for the generation of the three distinct but interconnected cell polarities of border cells. Specifically...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2018) 145 (5): dev154617.
Published: 1 March 2018
... for fast growth of Medicago truncatula root hairs . Plant Physiol.   130 , 977 - 988 . 10.1104/pp.004267 Siegrist , S. E. and Doe , C. Q. ( 2007 ). Microtubule-induced cortical cell polarity . Genes Dev.   21 , 483 - 496 . 10.1101/gad.1511207 Takahashi , T. , Naito , S...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2018) 145 (3): dev149336.
Published: 8 February 2018
... found in nature. In turn, this spacing relies on complex patterns of cell polarity that involve feedback between a signaling molecule – the plant hormone auxin – and its polar, cell-to-cell transport. Here, we review recent progress in understanding phyllotaxis and plant cell polarity and highlight...
Journal Articles
Journal: Development
Development (2017) 144 (24): 4704–4719.
Published: 15 December 2017
... differentiation of the collecting duct system. Kidney Branching morphogenesis Cell polarity Transcriptional regulation Gdnf-Gfrα1-Ret pathway Collecting duct Branching morphogenesis is the process by which simple epithelium arborizes into an elaborate network. The molecular and cellular...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (9): 1607–1618.
Published: 1 May 2017
... that it might be involved. To test this hypothesis, we conditionally deleted Numb on a Numbl mutant background just prior to gonadogenesis. Mutant gonads showed a loss of cell polarity in the surface epithelial layers, large interior cell patches expressing the undifferentiated cell marker LHX9, and a loss...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2017) 144 (3): 499–506.
Published: 1 February 2017
...Yumiko Sakai; Shigeo S. Sugano; Takashi Kawase; Makoto Shirakawa; Yu Imai; Yusuke Kawamoto; Hiroshi Sugiyama; Tsuyoshi Nakagawa; Ikuko Hara-Nishimura; Tomoo Shimada ABSTRACT Stem cell polarization is a crucial step in asymmetric cell division, which is a universal system for generating cellular...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (14): 2508–2520.
Published: 15 July 2015
...Isabelle Roszko; Diane S. Sepich; Jason R. Jessen; Anand Chandrasekhar; Lilianna Solnica-Krezel During vertebrate gastrulation, convergence and extension movements elongate embryonic tissues anteroposteriorly and narrow them mediolaterally. Planar cell polarity (PCP) signaling is essential...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (13): 2338–2351.
Published: 1 July 2015
..., the adaptor Spn-F and cytoplasmic dynein are required for localised transport and retention of polarised signalling factors. Cell elongation Cell polarity IKKε Ik2 Dynein Drosophila Highly polarized cells, such as neurons and epithelial cells, rely heavily on intracellular transport...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (9): 1606–1615.
Published: 1 May 2015
..., a process regulated by cell polarity proteins, HIPPO signaling and lineage-specific transcription factors such as CDX2. However, the regulatory mechanisms that operate upstream to specify the trophectoderm lineage have not been established. Here we report that transcription factor AP-2γ (TFAP2C) functions...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (23): 4569–4579.
Published: 1 December 2014
.... The function of Dg was examined in Xenopus laevis embryos by knockdown of Dg and overexpression and replacement of the endogenous Dg with a mutated form of the protein. This analysis revealed that Dg is required for correct laminin assembly, for cell polarization during mediolateral intercalation...
Includes: Supplementary data