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Keywords: Cell polarity
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Journal Articles
Journal: Development
Development (2025) 152 (8): dev204235.
Published: 22 April 2025
..., in cranial neural crest (NC) cell migration during Xenopus embryonic development. Our research reveals that Gαi2 interacts directly with the microtubule-associated protein EB1, regulating microtubule dynamics. We show that Gαi2 knockdown stabilizes microtubules, disrupts cell polarity and morphology...
Includes: Supplementary data
Journal Articles
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Biologists @ 100
Journal: Development
Development (2025) 152 (3): DEV202820.
Published: 17 February 2025
.... , Barandiaran , I. S. , Kraus , M. R. and Grapin-Botton , A. ( 2020 ). Apical restriction of the planar cell polarity component VANGL in pancreatic ducts is required to maintain epithelial integrity . Cell Rep. 31 , 107677 . 10.1016/j.celrep.2020.107677 Forster , D...
Journal Articles
Journal: Development
Development (2024) 151 (22): dev202777.
Published: 21 November 2024
... the vectorial polarity characteristic of epithelial cells. Whether cell polarization feeds back on the gene regulatory pathways governing hepatoblast differentiation is unknown. Here, we used primary mouse hepatoblasts to investigate the contribution of anisotropic apical expansion to hepatocyte differentiation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2024) 151 (20): dev202928.
Published: 10 September 2024
... and ROPGAP, regulate various aspects of gametophyte development in Marchantia , most likely by controlling the ROP cycling process. Rho/Rac GTPase signaling Bryophytes Organ formation Cell polarity Land plants Ministry of Education, Culture, Sports, Science and Technology http...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2024) 151 (7): dev202479.
Published: 10 April 2024
...Nadia I. Manzi; Bailey N. de Jesus; Yu Shi; Daniel J. Dickinson ABSTRACT During asymmetric cell division, cell polarity is coordinated with the cell cycle to allow proper inheritance of cell fate determinants and the generation of cellular diversity. In the Caenorhabditis elegans zygote, polarity...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2024) 151 (7): dev202370.
Published: 2 April 2024
... homology domain Cytoskeleton Cell polarity Gametogenesis Germ cell Spectraplakin Wellcome http://dx.doi.org/10.13039/100010269 080007 203144 092096 207496 Wellcome http://dx.doi.org/10.13039/100010269 Cancer Research UK http://dx.doi.org/10.13039/501100000289...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (16): dev201651.
Published: 24 August 2023
... neurons Neural differentiation Cell polarity Adherens junctions N-cadherin β-catenin Tcf/Lef transcription Chick Ministerio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 FJCI-2015-26175 PID2020-116806GB-I00 BFU2017-83562-P Ministerio de Economía y...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (8): dev201273.
Published: 21 April 2023
...Daniel B. Dranow; Pierre Le Pabic; Thomas F. Schilling ABSTRACT Non-canonical/β-catenin-independent Wnt signaling plays crucial roles in tissue/cell polarity in epithelia, but its functions have been less well studied in mesenchymal tissues, such as the skeleton. Mutations in non-canonical Wnt...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (17): dev200761.
Published: 8 September 2022
... differentiation. The heterozygous mutants were born with no pancreatic phenotype but displayed gradual acinar atrophy due to cell polarity defects in exocrine cells. Together, our findings imply a role for FAK in controlling the timing of pancreatic lineage commitment and/or differentiation in the embryonic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (22): dev199935.
Published: 18 November 2021
... over longer distances. National Institutes of Health R01GM100088 RNA localization Molecular motor Cell polarity Nanobody P body Summary: Use of proximity biotin ligation to identify components of a Dynein localization complex and the development of a nanobody-based...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2021) 148 (17): dev199417.
Published: 9 September 2021
...Nereo Kalebic; Takashi Namba ABSTRACT Cell polarity is fundamentally important for understanding brain development. Here, we hypothesize that the inheritance and flexibility of cell polarity during neocortex development could be implicated in neocortical evolutionary expansion. Molecular...
Journal Articles
Journal: Development
Development (2021) 148 (14): dev199549.
Published: 21 July 2021
... for neuron survival and hair cell polarity . EMBO Rep. 20 , e47097 . 10.15252/embr.201847097 Gao , Y. , Lui , W. , Lee , W. and Cheng , C. ( 2016 ). Polarity protein Crumbs homolog-3 (CRB3) regulates ectoplasmic specialization dynamics through its action on F-actin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (7): dev196956.
Published: 31 March 2021
... of electrostatic PM targeting of polarity proteins in regulating cell polarity. * These authors contributed equally to this work ‡ Author for correspondence ( [email protected] ) Handling Editor: Thomas Lecuit Competing interests The authors declare no competing or financial interests...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (24): dev186346.
Published: 21 December 2020
...Marek Mlodzik ABSTRACT Planar cell polarity (PCP) reflects cellular orientation within the plane of an epithelium. PCP is crucial during many biological patterning processes and for organ function. It is omnipresent, from convergent-extension mechanisms during early development through to terminal...
Journal Articles
Journal: Development
Development (2020) 147 (19): dev191981.
Published: 5 October 2020
...Elvis Huarcaya Najarro; Jennifer Huang; Adrian Jacobo; Lee A. Quiruz; Nicolas Grillet; Alan G. Cheng ABSTRACT Planar cell polarity (PCP) proteins localize asymmetrically to instruct cell polarity within the tissue plane, with defects leading to deformities of the limbs, neural tube and inner ear...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (15): dev176529.
Published: 9 August 2019
... Cell polarity Cargo adaptor Drosophila National Institutes of Health 10.13039/100000002 R01GM100088 Recent studies have shown that mRNA localization is a prevalent, potent and conserved mechanism used by cells to regulate protein sorting ( Lecuyer et al., 2007 ; Mili et al...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (9): dev174367.
Published: 1 May 2019
...Weiyi Xu; Anushree C. Gulvady; Gregory J. Goreczny; Eric C. Olson; Christopher E. Turner ABSTRACT Establishing apical-basal epithelial cell polarity is fundamental for mammary gland duct morphogenesis during mammalian development. While the focal adhesion adapter protein paxillin is a well...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (7): dev166819.
Published: 4 April 2019
... by the Salvador-Warts-Hippo pathway. In epithelial cells, the Hippo pathway integrates diverse biological inputs, such as cell polarity and cell-cell contacts, but Drosophila blood cells lack the conspicuous polarity of epithelial cells. Here, we show that the septate-junction components Cora and NrxIV promote...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (9): dev158444.
Published: 2 May 2018
... apical-basal polarity is remodeled and turned into front-back and inside-outside as well as apical-basal polarities, during collective migration. We find that the Crumbs (Crb) complex is required for the generation of the three distinct but interconnected cell polarities of border cells. Specifically...
Includes: Supplementary data