..., in cranial neural crest (NC) cell migration during Xenopus embryonic development. Our research reveals that Gαi2 interacts directly with the microtubule-associated protein EB1, regulating microtubule dynamics. We show that Gαi2 knockdown stabilizes microtubules, disrupts cell polarity and morphology...

.... , Barandiaran , I. S. , Kraus , M. R. and Grapin-Botton , A. ( 2020 ). Apical restriction of the planar cell polarity component VANGL in pancreatic ducts is required to maintain epithelial integrity . Cell Rep. 31 , 107677 . 10.1016/j.celrep.2020.107677 Forster , D...

... the vectorial polarity characteristic of epithelial cells. Whether cell polarization feeds back on the gene regulatory pathways governing hepatoblast differentiation is unknown. Here, we used primary mouse hepatoblasts to investigate the contribution of anisotropic apical expansion to hepatocyte differentiation...

... and ROPGAP, regulate various aspects of gametophyte development in Marchantia , most likely by controlling the ROP cycling process. Rho/Rac GTPase signaling Bryophytes Organ formation Cell polarity Land plants Ministry of Education, Culture, Sports, Science and Technology http...

...Nadia I. Manzi; Bailey N. de Jesus; Yu Shi; Daniel J. Dickinson ABSTRACT During asymmetric cell division, cell polarity is coordinated with the cell cycle to allow proper inheritance of cell fate determinants and the generation of cellular diversity. In the Caenorhabditis elegans zygote, polarity...

... homology domain Cytoskeleton Cell polarity Gametogenesis Germ cell Spectraplakin Wellcome http://dx.doi.org/10.13039/100010269 080007 203144 092096 207496 Wellcome http://dx.doi.org/10.13039/100010269 Cancer Research UK http://dx.doi.org/10.13039/501100000289...

... neurons Neural differentiation Cell polarity Adherens junctions N-cadherin β-catenin Tcf/Lef transcription Chick Ministerio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 FJCI-2015-26175 PID2020-116806GB-I00 BFU2017-83562-P Ministerio de Economía y...

...Daniel B. Dranow; Pierre Le Pabic; Thomas F. Schilling ABSTRACT Non-canonical/β-catenin-independent Wnt signaling plays crucial roles in tissue/cell polarity in epithelia, but its functions have been less well studied in mesenchymal tissues, such as the skeleton. Mutations in non-canonical Wnt...

... differentiation. The heterozygous mutants were born with no pancreatic phenotype but displayed gradual acinar atrophy due to cell polarity defects in exocrine cells. Together, our findings imply a role for FAK in controlling the timing of pancreatic lineage commitment and/or differentiation in the embryonic...

... over longer distances. National Institutes of Health R01GM100088 RNA localization Molecular motor Cell polarity Nanobody P body Summary: Use of proximity biotin ligation to identify components of a Dynein localization complex and the development of a nanobody-based...

... in Arabidopsis . Cell 137 , 1320 - 1330 . 10.1016/j.cell.2009.04.018 Drubin , D. G. and Nelson , W. J. ( 1996 ). Origins of cell polarity . Cell 84 , 335 - 344 . 10.1016/S0092-8674(00)81278-7 Engineer , C. B. , Ghassemian , M. , Anderson , J. C. , Peck , S. C...

...Nereo Kalebic; Takashi Namba ABSTRACT Cell polarity is fundamentally important for understanding brain development. Here, we hypothesize that the inheritance and flexibility of cell polarity during neocortex development could be implicated in neocortical evolutionary expansion. Molecular...

... for neuron survival and hair cell polarity . EMBO Rep. 20 , e47097 . 10.15252/embr.201847097 Gao , Y. , Lui , W. , Lee , W. and Cheng , C. ( 2016 ). Polarity protein Crumbs homolog-3 (CRB3) regulates ectoplasmic specialization dynamics through its action on F-actin...

... of electrostatic PM targeting of polarity proteins in regulating cell polarity. * These authors contributed equally to this work ‡ Author for correspondence ( [email protected] ) Handling Editor: Thomas Lecuit Competing interests The authors declare no competing or financial interests...

...Marek Mlodzik ABSTRACT Planar cell polarity (PCP) reflects cellular orientation within the plane of an epithelium. PCP is crucial during many biological patterning processes and for organ function. It is omnipresent, from convergent-extension mechanisms during early development through to terminal...

...Elvis Huarcaya Najarro; Jennifer Huang; Adrian Jacobo; Lee A. Quiruz; Nicolas Grillet; Alan G. Cheng ABSTRACT Planar cell polarity (PCP) proteins localize asymmetrically to instruct cell polarity within the tissue plane, with defects leading to deformities of the limbs, neural tube and inner ear...

... Cell polarity Cargo adaptor Drosophila National Institutes of Health 10.13039/100000002 R01GM100088 Recent studies have shown that mRNA localization is a prevalent, potent and conserved mechanism used by cells to regulate protein sorting ( Lecuyer et al., 2007 ; Mili et al...

...Weiyi Xu; Anushree C. Gulvady; Gregory J. Goreczny; Eric C. Olson; Christopher E. Turner ABSTRACT Establishing apical-basal epithelial cell polarity is fundamental for mammary gland duct morphogenesis during mammalian development. While the focal adhesion adapter protein paxillin is a well...

... by the Salvador-Warts-Hippo pathway. In epithelial cells, the Hippo pathway integrates diverse biological inputs, such as cell polarity and cell-cell contacts, but Drosophila blood cells lack the conspicuous polarity of epithelial cells. Here, we show that the septate-junction components Cora and NrxIV promote...

... apical-basal polarity is remodeled and turned into front-back and inside-outside as well as apical-basal polarities, during collective migration. We find that the Crumbs (Crb) complex is required for the generation of the three distinct but interconnected cell polarities of border cells. Specifically...