... neurons Neural differentiation Cell polarity Adherens junctions N-cadherin β-catenin Tcf/Lef transcription Chick Ministerio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 FJCI-2015-26175 PID2020-116806GB-I00 BFU2017-83562-P Ministerio de Economía y...

...Daniel B. Dranow; Pierre Le Pabic; Thomas F. Schilling ABSTRACT Non-canonical/β-catenin-independent Wnt signaling plays crucial roles in tissue/cell polarity in epithelia, but its functions have been less well studied in mesenchymal tissues, such as the skeleton. Mutations in non-canonical Wnt...

... differentiation. The heterozygous mutants were born with no pancreatic phenotype but displayed gradual acinar atrophy due to cell polarity defects in exocrine cells. Together, our findings imply a role for FAK in controlling the timing of pancreatic lineage commitment and/or differentiation in the embryonic...

.... , Brand , A. H. , Roth , S. and Guichet , A. ( 2002 ). Polar transport in the Drosophila oocyte requires Dynein and Kinesin I cooperation . Curr. Biol. 12 , 1971 - 1981 . 10.1016/S0960-9822(02)01302-7 Jossin , Y. ( 2020 ). Molecular mechanisms of cell polarity in a range...

.... , Varnau , R. , Wallner , E.-S. , Acharya , R. , Bergmann , D. C. and Cheung , L. S. ( 2021b ). Quantitative and dynamic cell polarity tracking in plant cells . New Phytol. 230 , 867 - 877 . 10.1111/nph.17165 Gonsalvez , D. G. , Li-Yuen-Fong , M. , Cane , K. N...

...Nereo Kalebic; Takashi Namba ABSTRACT Cell polarity is fundamentally important for understanding brain development. Here, we hypothesize that the inheritance and flexibility of cell polarity during neocortex development could be implicated in neocortical evolutionary expansion. Molecular...

.... , Thelen , N. , Thiry , M. , Morelli , G. , Van Hees , L. , Laguesse , S. et al. ( 2019 ). Proteostasis is essential during cochlear development for neuron survival and hair cell polarity . EMBO Rep. 20 , e47097 . 10.15252/embr.201847097 Gao , Y. , Lui , W...

... of electrostatic PM targeting of polarity proteins in regulating cell polarity. In all quantifications, a two-tailed Student's t -test was carried out to calculate the P value. Differences with P >0.05 are considered to be statistically insignificant. We are grateful to Drs David Bilder, Helena...

...Marek Mlodzik ABSTRACT Planar cell polarity (PCP) reflects cellular orientation within the plane of an epithelium. PCP is crucial during many biological patterning processes and for organ function. It is omnipresent, from convergent-extension mechanisms during early development through to terminal...

...Elvis Huarcaya Najarro; Jennifer Huang; Adrian Jacobo; Lee A. Quiruz; Nicolas Grillet; Alan G. Cheng ABSTRACT Planar cell polarity (PCP) proteins localize asymmetrically to instruct cell polarity within the tissue plane, with defects leading to deformities of the limbs, neural tube and inner ear...

.../ Summary: An shRNA depletion strategy has uncovered the role of Dlc in the dimerization of Egl, further revealing a step-wise assembly pathway for building a localization-competent mRNP. RNA localization Molecular motor Kinesin Cell polarity Cargo adaptor Drosophila Recent studies...

...Weiyi Xu; Anushree C. Gulvady; Gregory J. Goreczny; Eric C. Olson; Christopher E. Turner ABSTRACT Establishing apical-basal epithelial cell polarity is fundamental for mammary gland duct morphogenesis during mammalian development. While the focal adhesion adapter protein paxillin is a well...

... by the Salvador-Warts-Hippo pathway. In epithelial cells, the Hippo pathway integrates diverse biological inputs, such as cell polarity and cell-cell contacts, but Drosophila blood cells lack the conspicuous polarity of epithelial cells. Here, we show that the septate-junction components Cora and NrxIV promote...

... apical-basal polarity is remodeled and turned into front-back and inside-outside as well as apical-basal polarities, during collective migration. We find that the Crumbs (Crb) complex is required for the generation of the three distinct but interconnected cell polarities of border cells. Specifically...

... into F1 wild-type sporelings derived from crosses between Tak-1 and Tak-2. Cell polarity Marchantia polymorpha NIMA-related kinase Rhizoid Tip growth Summary: MpNEK1 regulates growth directionality in tip-growing rhizoids, the single-celled structures that mediate nutrient absorption...

... found in nature. In turn, this spacing relies on complex patterns of cell polarity that involve feedback between a signaling molecule – the plant hormone auxin – and its polar, cell-to-cell transport. Here, we review recent progress in understanding phyllotaxis and plant cell polarity and highlight...

... of the collecting duct system. Kidney Branching morphogenesis Cell polarity Transcriptional regulation Gdnf-Gfrα1-Ret pathway Collecting duct Branching morphogenesis is the process by which simple epithelium arborizes into an elaborate network. The molecular and cellular events underlying...

... that it might be involved. To test this hypothesis, we conditionally deleted Numb on a Numbl mutant background just prior to gonadogenesis. Mutant gonads showed a loss of cell polarity in the surface epithelial layers, large interior cell patches expressing the undifferentiated cell marker LHX9, and a loss...

...Yumiko Sakai; Shigeo S. Sugano; Takashi Kawase; Makoto Shirakawa; Yu Imai; Yusuke Kawamoto; Hiroshi Sugiyama; Tsuyoshi Nakagawa; Ikuko Hara-Nishimura; Tomoo Shimada ABSTRACT Stem cell polarization is a crucial step in asymmetric cell division, which is a universal system for generating cellular...

...Isabelle Roszko; Diane S. Sepich; Jason R. Jessen; Anand Chandrasekhar; Lilianna Solnica-Krezel During vertebrate gastrulation, convergence and extension movements elongate embryonic tissues anteroposteriorly and narrow them mediolaterally. Planar cell polarity (PCP) signaling is essential...