... different modes of migration likely enables leukocyte and cancer cell migration across distinct and heterogeneous tissues. However, direct comparisons of cell migration strategies across diverse tissue environments in vivo are lacking. In addition to DETCs, additional T-cell populations leave the thymus...

...Soraya Villaseca; Juan Ignacio Leal; Lina Mariana Tovar; María José Ruiz; Jossef Guajardo; Hernan Morales-Navarrete; Roberto Mayor; Marcela Torrejón ABSTRACT Cell migration is crucial in embryonic development, tissue repair and cancer metastasis, driven by the actin and tubulin cytoskeletons...

... and reproduction in any medium provided that the original work is properly attributed. Summary: Mcf2lb, a RhoA GEF, regulates rosette integrity through modulating apical constriction of cells within rosettes during collective cell migration. Cell migration Rosette morphogenesis Sensory development...

... Highlighted Article: Brain perivascular fibroblasts migrate from their origin in the meninges and proliferate locally to fully cover penetrating vessels during postnatal mouse development. Neurovascular unit Meninges Cell migration Perivascular spaces Perivascular macrophages Cerebral vasculature...

... attributed. Summary: Examination of the migration and morphogenesis of Drosophila visceral muscle precursors reveals how these multinucleated precursors form the stereotypic arrangement of longitudinal gut muscles and identifies Tey as a crucial regulator of this process. Cell migration...

...Ezra Lencer; Addison Rains; Erin Binne; Rytis Prekeris; Kristin B. Artinger ABSTRACT The transmembrane proteins cdon and boc are implicated in regulating hedgehog signaling during vertebrate development. Recent work showing roles for these genes in axon guidance and neural crest cell migration...

...Yichi Xu; Yunsheng Cheng; Allison T. Chen; Zhirong Bao ABSTRACT The formation of sequential rosettes is a type of collective cell behavior recently discovered in the Caenorhabditis elegans embryo that mediates directional cell migration through sequential formation and resolution of multicellular...

... mechanism of SCP emigration from the somites, we performed whole-mount in situ hybridization (WISH) analysis for genes encoding cell adhesion molecules, generally involved in cell migration, during SCP emergence in the caudal somites and the ensuing migration period. We found no cadherin expression...

.... Twist1 -interacting Irf6 is involved in regulating neural tube integrity. Mouse genetics Neural tube closure Epithelial-to-mesenchymal transition Neural tube explants Cell delamination Cell migration University of Texas Health Science Center at Houston http://dx.doi.org/10.13039...

...Naoya Yamaguchi; Holger Knaut ABSTRACT Cell-extracellular matrix interactions have been studied extensively using cells cultured in vitro . These studies indicate that focal adhesion (FA)-based cell-extracellular matrix interactions are essential for cell anchoring and cell migration. Whether FAs...

..., leading to increased speed of migration. Moreover, overactivation of Rac1, due to Piezo1 inhibition, counteracts cell migration inhibitory signals by Semaphorin 3A and Semaphorin 3F, generating aberrant neural crest invasion in vivo . Thus, we find that, for directional migration in vivo , neural crest...

...Jessica Stock; Andrea Pauli ABSTRACT Self-organization is a key feature of many biological and developmental processes, including cell migration. Although cell migration has traditionally been viewed as a biological response to extrinsic signals, advances within the past two decades have...

... movement at the leading edge mesendoderm surface allows this tissue to move by being pulled forward by cells at its front end. Xenopus X-ray tomography Gastrulation Cell migration Surface tension Mass cell migration positions organ rudiments during development. In the Xenopus gastrula...

..., consistent with its migration arrest being temporally regulated, its final position is sensitive to body size. Cell migration Neuroblast Robustness Body size C. elegans Human Frontier Science Program http://dx.doi.org/10.13039/100004412 RGP0030/2016 Cell migration is a key...

... in the mouse. This collective cell migration is preceded by a columnar-to-squamous transition in visceral endoderm cells that depends on MLL4. Furthermore, Mll4 mutants display incompletely penetrant, sex-distorted, embryonic haploinsufficiency and adult heterozygous mutants show aspects of Kabuki syndrome...

...Abhinava K. Mishra; Joseph P. Campanale; James A. Mondo; Denise J. Montell ABSTRACT Collective cell migration is the coordinated movement of a physically connected group of cells and is a prominent driver of development and metastasis. Interactions between cells within migrating collectives...

... the importance of cholesterol modification in the processing and long-distance transmission of the Hh ligand, we have analyzed the involvement of the Niemann-Pick disease type C-1a (NPC1a) protein, a cholesterol transporter, in germ cell migration and Hedgehog signaling. We show that mesoderm-specific...

... overlying the extra-embryonic ectoderm shows coherent cell growth in a proximal-anterior to distal-posterior direction. We also observed that directional cell migration is coupled with cell elongation in the anterior region. Our observations suggest that the behaviors of visceral endoderm cells vary between...

..., and a constitutively active form of Src efficiently rescues the Gα13 morphant phenotype in NC cells. We propose that Ric-8A-mediated Gα13 signalling is required for proper cranial NC cell migration by regulating focal adhesion dynamics and protrusion formation. * Authors for correspondence ([email protected]...

... extracellular matrix deposition, creating an environment conducive to this migration. Glypican 4 Endoderm Cell migration Imaging Extracellular matrix National Science Foundation 10.13039/100000001 IOS-1354457 The endoderm, the deepest germ layer, contributes to the development...