.... Early mammalian development Extracellular matrix Cell fate specification Patterning European Molecular Biology Laboratory http://dx.doi.org/10.13039/100013060 European Research Council http://dx.doi.org/10.13039/100010663 Development results in an immense diversity...

...-sensitizing mutations. The resulting datasets yielded distinct, reproducible signature phenotypes for a broad spectrum of genes that are involved in cell fate specification and morphogenesis. In addition, our analysis provides new in vivo evidence for MBK-2 function in mesoderm fate specification and LET-381...

...-enriched genes. Collectively, our analyses have successfully determined the gene regulation dynamics associated with the development of different diencephalic lineages. Our data provide a valuable resource for interrogation of cell fate specification and differentiation in the developing...

..., but by several regulators acting in different combinations to govern different aspects of this cell fate. Cell fate specification Terminal selector Axon pathfinding Genetic cascades Feedforward loops University of Iowa 10.13039/100008893 2017-0440601 Vetenskapsrådet 10.13039...

...-repressor Groucho by the transcriptional activator Pointed confers precision and robustness to the gene expression dynamics that drive developmental cell fate transitions. Gene regulatory network Cell fate specification Chromatin occupancy Mesoderm development RNA pol II pausing Genetic...

... to maintain a proper balance between self-renewal and differentiation towards neuronal or glial lineages. TALE-homeodomain protein Adult neurogenesis Subventricular zone Cell fate specification Doublecortin Pioneer factor Highlighted article: The TALE-homeodomain protein PBX1 promotes...

... to control photoreceptor cell fate specification. Because of their unique morphology and gene expression profiles, photoreceptors were among the few neuronal subtypes that could be identified reliably in vitro . This allowed for the identification of soluble regulators of photoreceptor cell fate...

... for studying the molecular mechanisms underlying neuronal cell fate specification ( Technau et al., 2006 ). Drosophila Central nervous system CCAP Bursicon Cell fate specification Temporal identity factors Hunchback © 2014. Published by The Company of Biologists Ltd 2014 27 5 2014...

[email protected] ) Competing interests statement The authors declare no competing financial interests. 20 7 2011 © 2011. BMP Cell fate specification Body axis Neurogenesis Nervous system development in bilaterians is composed of a number of developmental processes...

... financial interests. 16 2 2010 © 2010. 2010 FoxF FoxC let-381 Forkhead domain ceh-34 SIX2 homeodomain eya-1 Eyes absent Mesoderm Cell fate specification M lineage Coelomocyte Asymmetry C. elegans Proper animal development requires that each cell precisely...

... mechanisms described. Taken together, although cell death might underlie aspects of the foxd3 zdf10 ; tfap2a low double mutant phenotype, it is unlikely to entirely account for it. Ultimately, it will be important to determine whether and to what extent defects in NC sublineage cell fate specification...

...: [email protected] ; [email protected] ) 28 7 2008 © 2008. 2008 FGF signaling Wnt signaling Cell fate specification Cell proliferation Limb development Multipotency Growth, patterning and cellular differentiation are inextricably linked during development...

... in the development of DRG neuron subsets. Several lines of evidence have suggested that Runx3 plays a crucial role in the cell fate specification of proprioceptive DRG neurons( Inoue et al., 2002 ; Levanon et al., 2002 ; Kramer et al., 2006 ). The expression of PV, a specific marker for proprioceptive DRG...

... for correspondence (e-mail: [email protected] ) * These authors contributed equally to this work 24 5 2007 © 2007. 2007 Forkhead genes Cell fate specification Differentiation Dopaminergic Midbrain Gene dosage Midbrain dopaminergic (mDA) neurons represent an important class...

...Shuyi Huang; Premnath Shetty; Scott M. Robertson; Rueyling Lin C. elegans embryos exhibit an invariant lineage comprised primarily of a stepwise binary diversification of anterior-posterior (A-P)blastomere identities. This binary cell fate specification requires input from both the Wnt and MAP...

...Barbara D. Page; Scott J. Diede; Jennifer R. Tenlen; Edwin L. Ferguson During early divisions of the C. elegans embryo, many maternally supplied determinants accumulate asymmetrically, and this asymmetry is crucial for proper cell fate specification. SKN-1, a transcription factor whose message...

... events and helps program cell fate specification and cell invasion. References Bailey, A. M. and Posakony, J. W. ( 1995 ). Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity. Genes Dev. 9 , 2609 -2622...

... and cc609 and 81% penetrance in cc610 ( Table 1 , Fig. 2 ). * Author for correspondence (e-mail: [email protected] ) 20 10 2006 © 2007. 2007 fozi-1 Formin FH2 domain Zinc finger Mesoderm Cell fate specification M lineage Body wall muscle HLH-1 CeMyoD MAB-5 CEH-20...

.... † Author for correspondence (e-mail: [email protected] ) * These authors contributed equally to this work 5 6 2006 © 2006. 2006 Mesoderm C. elegans tbx-35 Cell fate specification The invention of mesoderm marked the defining event in the emergence...

... © 2006. 2006 Neural development Cell fate specification Sea urchin Animal plate Ectoderm Cellular signaling As the animal plate forms one pole of the animal-vegetal axis of the sea urchin embryo, it has figured prominently in studies of cell fate specification. Early...