... for telencephalic development and that the interplay between Notch and miRNAs is essential for the control of neocortical progenitor behaviors and neuron cell fate decisions. Although the ChP is properly patterned and establishes a sharp boundary with the CH, we identified ectopic reelin + cells in the ChP...

... in the adult mouse and human retina, including a conserved region nearby Prdm1 , a factor implicated in the specification of rod photoreceptors and suppression of bipolar cell fate. VSX2 interacts with the transcription factor OTX2 and can act to suppress OTX2-dependent enhancer transactivation of the Prdm1...

... pellucida, highlighting a potential risk of sexually transmitted infection in early pregnancy. Zika virus (ZIKV) Birth defects Miscarriage Developmental biology Cell fate Epidemic Michigan State University http://dx.doi.org/10.13039/100007709 National Institute of General...

... change their cell fate into epicardial-like cells. wt1a wt1b Heart development Cardiomyocyte Epicardium Zebrafish Cell fate Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung http://dx.doi.org/10.13039/501100001711 320030E-164245 310030L_182575...

... Cell fate Cell plasticity Diabetes European Research Council http://dx.doi.org/10.13039/100010663 ERC-StG 715361 SPACEVAR Fonds de la Recherche Scientifique 34772792 – SCHISM Technische Universitat Dresden Deutsches Zentrum für Diabetesforschung...

... results from M cells prematurely adopting a head epidermis fate. This switch in fate normally takes place during pupal development after the eye has been patterned. Our results suggest that the timing of cell fate decisions is essential for correct eye development. We used the expression patterns...

... of the Wnt/β-catenin pathway, which is required for melanocyte development, induces activation of Mitf-M, in turn repressing FoxD3 expression. In conclusion, β-catenin overexpression promotes SCP cell fate decisions towards the melanocyte lineage. 501mel and SK28 human melanoma cell lines were grown...

... interneuron formation. Cell fate microRNA Retina Neurogenesis National Institutes of Health R01EY024996 R21EY018707 Midwest Eye-Banks (Eversight) University of Michigan http://dx.doi.org/10.13039/100007270 Cellular diversity is a fundamental feature...

...Megan K. Rommelfanger; Adam L. MacLean ABSTRACT Cells do not make fate decisions independently. Arguably, every cell-fate decision occurs in response to environmental signals. In many cases, cell-cell communication alters the dynamics of the internal gene regulatory network of a cell to initiate...

...Lluc Mosteiro; Hanaa Hariri; Jelle van den Ameele ABSTRACT The intimate relationships between cell fate and metabolism have long been recognized, but a mechanistic understanding of how metabolic pathways are dynamically regulated during development and disease, how they interact with signalling...

...Natalie J. Milmoe; Abigail S. Tucker ABSTRACT Within the developing head, tissues undergo cell-fate transitions to shape the forming structures. This starts with the neural crest, which undergoes epithelial-to-mesenchymal transition (EMT) to form, amongst other tissues, many of the skeletal tissues...

... represses the rod-promoting factor Nrl to control the timing of cone genesis in the mouse retina. Cell fate Mouse Photoreceptors Retina Temporal patterning Transcription The generation of neuronal diversity is crucial to building a functional nervous system. Classical studies have shown...

... regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak . Dev. Cell   1 , 37 - 49 . 10.1016/S1534-5807(01)00017-X Corbo , J. C. , Levine , M. and Zeller , R. W. ( 1997 ). Characterization of a notochord-specific enhancer from the Brachyury...

...Marta N. Shahbazi ABSTRACT Gene regulatory networks and tissue morphogenetic events drive the emergence of shape and function: the pillars of embryo development. Although model systems offer a window into the molecular biology of cell fate and tissue shape, mechanistic studies of our own...

... in development and evolution, the LPM remains challenging to study and to delineate, owing to its lineage complexity and lack of a concise genetic definition. Here, we outline the processes that govern LPM specification, organization, its cell fates and the inferred evolutionary trajectories of LPM-derived...

... significance was calculated using the nonparametric, unpaired Mann–Whitney test. The numbers in brackets refer to the numbers of animals scored for each condition. *P<0.05, **P<0.01. Scale bars: 5 μm. C. elegans vulval cell fate specification serves as an excellent in vivo model to analyze...

... behaviours and ensure robust morphogenesis and patterning during development. Luminal pressure Luminogenesis Signalling Cell fate Tissue patterning Tissue mechanics In many epithelial tissues, cells secrete intercellular fluid that leads to the de novo formation of the lumen (see...

... of basal stem cells is regulated during postnatal prostate development in mouse. Stem cells Prostate development Basal multipotency Cell fate Lineage tracing Mouse The prostate is a glandular organ of the male reproductive system in mammals. It resides around the urethra and underneath...

... in mouse Müllerian duct mesenchyme cells caused them to adopt the myofibroblast cell fate, resulting in profound reproductive tract developmental defects and sterility. Myofibroblast differentiation was attributed to increased YAP and TAZ expression (but not to altered WNT signaling), leading to the direct...

... no competing or financial interests. © 2019. Published by The Company of Biologists Ltd 2019 Summary: This Meeting Review discusses how recent technological advances have impacted the study of cell types and how this might change our view of cell type identity and evolution. Cell fate...