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Keywords: Cell fate
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Journal Articles
Journal: Development
Development (2021) 148 (4): dev196030.
Published: 15 February 2021
...Natalie J. Milmoe; Abigail S. Tucker ABSTRACT Within the developing head, tissues undergo cell-fate transitions to shape the forming structures. This starts with the neural crest, which undergoes epithelial-to-mesenchymal transition (EMT) to form, amongst other tissues, many of the skeletal tissues...
Journal Articles
Journal: Development
Development (2020) 147 (18): dev188730.
Published: 28 September 2020
... Nrl, which is restricted to post-mitotic photoreceptor precursors ( Oh et al., 2007 ; Mears et al., 2001 ). Together with our finding that Pou2f2 is able to induce the cone fate when expressed from the Nrl promoter, this is further evidence that Pou2f2 primarily regulates cell fate decisions in...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (15): dev186965.
Published: 14 August 2020
... cell shape changes during ascidian endoderm invagination, and shows that fate specification is in part uncoupled from the control of morphogenesis in early ascidian embryos. Nodal Ephrin Gastrulation Morphogenesis Cell fate Epithelial invagination, the buckling of a sheet of cells...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2020) 147 (14): dev190629.
Published: 17 July 2020
...Marta N. Shahbazi ABSTRACT Gene regulatory networks and tissue morphogenetic events drive the emergence of shape and function: the pillars of embryo development. Although model systems offer a window into the molecular biology of cell fate and tissue shape, mechanistic studies of our own...
Journal Articles
Journal: Development
Development (2020) 147 (12): dev175059.
Published: 19 June 2020
... in development and evolution, the LPM remains challenging to study and to delineate, owing to its lineage complexity and lack of a concise genetic definition. Here, we outline the processes that govern LPM specification, organization, its cell fates and the inferred evolutionary trajectories of LPM...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (11): dev175760.
Published: 04 June 2020
... required for the polarized and directional secretion of the epidermal growth factor during vulval development in C. elegans . C. elegans Epidermal growth factor Polarity Cell fate Intercellular communication relies on the spatially and temporally controlled release of signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (5): dev181297.
Published: 02 March 2020
... how mechanical cues from the lumen can polarize the cytoskeleton and trigger cell migration and proliferation. Next, we evaluate how the lumen can provide signalling cues to guide cell-fate specification and tissue patterning. Finally, we review examples showing how the integration of mechanical and...
Journal Articles
Journal: Development
Development (2019) 146 (20): dev180224.
Published: 23 October 2019
... basal stem cells is regulated during postnatal prostate development in mouse. Stem cells Prostate development Basal multipotency Cell fate Lineage tracing Mouse The prostate is a glandular organ of the male reproductive system in mammals. It resides around the urethra and underneath...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2019) 146 (20): dev180430.
Published: 18 October 2019
... in mouse Müllerian duct mesenchyme cells caused them to adopt the myofibroblast cell fate, resulting in profound reproductive tract developmental defects and sterility. Myofibroblast differentiation was attributed to increased YAP and TAZ expression (but not to altered WNT signaling), leading to the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (18): dev178996.
Published: 19 September 2019
... interests. © 2019. Published by The Company of Biologists Ltd 2019 Summary: This Meeting Review discusses how recent technological advances have impacted the study of cell types and how this might change our view of cell type identity and evolution. Cell fate Computational analysis...
Journal Articles
Journal: Development
Development (2019) 146 (18): dev167106.
Published: 16 September 2019
... Wnt, Hedgehog and TGFβ pathways), Hippo signalling is a ‘jack of all trades’ that is reiteratively used to mediate a range of cellular decision-making processes from proliferation, death and morphogenesis to cell fate determination. Here, and in the accompanying poster, we briefly outline the core...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (16): dev176586.
Published: 21 August 2019
... these projection neurons. Cell fate Cell potency In vivo reprogramming Regeneration RGC The most prevalent cause of irreversible blindness worldwide is degeneration of the neurons that connect the retina to the brain, the retinal ganglion cells (RGCs) ( Pascolini and Mariotti, 2012...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (7): dev170498.
Published: 01 April 2019
... early mesoderm cell fate decisions. We found that Cdx2 occupies a number of transcription factor loci during embryogenesis, including key regulators of both cardiac and blood development, and that Cdx function is required for normal expression of the cardiogenic transcription factors Nkx2-5 and Tbx5...
Includes: Supplementary data
Journal Articles
In collection:
Advocacy
Journal: Development
Development (2019) 146 (5): dev169821.
Published: 11 March 2019
... contribute to enrich our understanding of cancers and congenital malformations. Cell fate Neural crest Neurocristopathies Vertebrate embryo One of the most profound discoveries in NC research was that of its paramount role in building the vertebrate head. Among multi-cellular organisms, it...
Journal Articles
Journal: Development
Development (2019) 146 (3): dev172148.
Published: 01 February 2019
.... © 2019. Published by The Company of Biologists Ltd 2019 Summary: Notch receptors relay information from the cell surface to the genome via a simple signaling mechanism. Yet Notch plays multiple roles: its various outputs arise, in part, from signaling dynamics. Cell fate Notch Patterning...
Journal Articles
Journal: Development
Development (2018) 145 (22): dev168096.
Published: 15 November 2018
.... elegans touch receptor neurons by inhibiting a TEA domain-containing repressor, revealing its role in neuronal fate choice. Cell fate Neuronal differentiation Binary decision Repressors Touch receptor neurons ZEB The six C. elegans TRNs include two pairs of embryonically derived and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (9): dev159970.
Published: 30 April 2018
... neurogenesis and gliogenesis. Cell fate Co-factor Gliogenesis Neurogenesis Retina Transcription factor Lhx2 is one of 12 genes that make up the LIM class homeodomain (LIM-HD) family of transcription factors (TFs). Lhx2 is dynamically expressed in multiple tissues, including discrete...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (9): dev156018.
Published: 25 April 2018
... Toll/TLRs carry out previously unanticipated functions in development, regulating cell fate, cell number, neural circuit connectivity and synaptogenesis. Furthermore, knowledge of their molecular mechanisms of action is expanding and has highlighted that Toll/TLRs function beyond the canonical NF-κB...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (8): dev143420.
Published: 13 April 2018
... defense against senescence. Stem cell Mitochondria Cell fate Aging In adults, tissue-specific stem cells maintain tissue homeostasis and provide committed progenitors for regeneration after tissue injury. To maintain the stem cell pool and provide progenitors for tissue-specific cell...
Journal Articles
Journal: Development
Development (2018) 145 (3): dev159178.
Published: 08 February 2018
...   301 , 1911 - 1914 . 10.1126/science.1087419 Kucherenko , M. M. , Barth , J. , Fiala , A. and Shcherbata , H. R. ( 2012 ). Steroid-induced microRNA let-7 acts as a spatio-temporal code for neuronal cell fate in the developing Drosophila brain . EMBO J.   31 , 4511 - 4523...
Includes: Supplementary data