... of the neuroectoderm on the embryo surface and migrate to the embryo interior, where they go on to form the central nervous system ( An et al., 2017 ; Simões et al., 2017 ); 3) cell extrusion, which is the removal of unwanted or dying cells from the epithelium and induction into cell death as part of developmental...

..., there is a dramatic remodeling of the epithelium that involves the complete loss of MCCs. Cell extrusion is a well-characterized process for driving cell loss while maintaining epithelial barrier function. Normal cell extrusion is typically unidirectional, whereas bidirectional extrusion is often associated...

... shelves and must be removed to allow mesenchymal confluence. Abundant apoptosis and cell extrusion support their importance in MES removal. However, genetically disrupting the intrinsic apoptotic regulators BAX and BAK within the MES results in complete loss of cell death and cell extrusion...

...Xianlong Ai; Dan Wang; Junzheng Zhang; Jie Shen ABSTRACT Cell extrusion is a crucial regulator of epithelial tissue development and homeostasis. Epithelial cells undergoing apoptosis, bearing pathological mutations or possessing developmental defects are actively extruded toward elimination...

... between caspase activation and E-cadherin. Endocytosis Tissue remodeling Epithelial cell elimination Cell extrusion Myosin II E-cadherin Caspase Drosophila Japan Science and Technology Agency 10.13039/501100002241 JPMJCR1852 Astellas Foundation for Research...

... a developmental switch in the cell extrusion mechanism that correlates with changes in tissue mechanical properties. * Author for correspondence ( [email protected] ) Competing interests The authors declare no competing or financial interests. 16 4 2019 28 1 2020 ©...

... PE cells to extrude apically. We provide evidence that cell extrusion, which has been described in the elimination of unfit cells from epithelia and the emergence of hematopoietic stem cells, is also a mechanism for PE cells to exit an organized mesothelium and fulfil their developmental fate to form...