..., impacting regenerative growth. The intracellular location of Yap is tightly associated with different cell densities along the blastema proximal-distal axis, which correlate with alterations in cell morphology, cytoskeleton and cell-cell contacts in a gradient-like manner. Importantly, Yap inactivation...

...José Javier Otero; Weimin Fu; Lixin Kan; Adolfo E. Cuadra; John A. Kessler Culture of embryonic stem (ES) cells at high density inhibits bothβ-catenin signaling and neural differentiation. ES cell density does not influence β-catenin expression, but a greater proportion ofβ-catenin is targeted...

... mesenchyme formed cartilage sheets whilst limb bud mesenchyme formed distinct cartilage nodules. It was thus suggested by these authors that this morphogenesis was tissue type specific. However, by varying cell density at inoculation (which controls cell configuration) and by varying the relative amount...