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Keywords: Cell cycle
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Journal Articles
Journal: Development
Development (2021) 148 (9): dev195552.
Published: 29 April 2021
... Summary: This Review synthesizes current understanding of Hedgehog signal transduction, ligand secretion and transport, and cilia dynamics to explore the temporal and spatial constraints imposed by the primary cilium on Hedgehog signaling in vivo . Hedgehog Cell cycle Cilia Signaling...
Journal Articles
Journal: Development
Development (2021) 148 (8): dev198838.
Published: 16 April 2021
... differentiation. However, the functional mechanism of Arid1a in the fate commitment of mesenchymal stem cells (MSCs) and their progeny is not clear. Using the continuously growing adult mouse incisor model, we show that Arid1a maintains tissue homeostasis through limiting proliferation, promoting cell cycle exit...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (3): dev165084.
Published: 08 February 2021
...Noelia Urbán; Tom H. Cheung ABSTRACT Quiescence is a cellular state in which a cell remains out of the cell cycle but retains the capacity to divide. The unique ability of adult stem cells to maintain quiescence is crucial for life-long tissue homeostasis and regenerative capacity. Quiescence has...
Journal Articles
Journal: Development
Development (2020) 147 (14): dev189712.
Published: 24 July 2020
... cell cycle. These combined effects partner to establish and sustain a pool of rapidly proliferating radial glial progenitors in vitro . We also show that, in conditions of variable proliferation dynamics, the branching process tool outperforms other commonly used methods based on thymidine analogs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (21): dev180273.
Published: 06 November 2019
... thereafter balancing SSC renewal versus terminal differentiation. Here, we report that precise regulation of the cell cycle is crucial for this balance. Whereas cyclin-dependent kinase 2 ( Cdk2 ) is not necessary for mouse viability or gametogenesis stages prior to meiotic prophase I, mice bearing a...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev178871.
Published: 24 October 2019
... proliferation is drastically reduced, but resumes when food becomes available. Here, we investigate how neural progenitors halt cell division in response to nutrient restriction and subsequently re-enter the cell cycle upon feeding. We demonstrate that nutrient restriction causes neural progenitors to arrest in...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev177550.
Published: 10 October 2019
... SHH-driven medulloblastoma. GSK-3 WNT Cerebellar development Medulloblastoma Cell cycle Postnatal neurogenesis Mouse Strict control of progenitor proliferation and differentiation are required for brain growth. Inadequate proliferation causes microcephaly whereas excessive...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (19): dev177402.
Published: 04 October 2019
...Sudarshan Chari; Henry Wilky; Jayalakshmi Govindan; Amanda A. Amodeo ABSTRACT The early embryos of many animals, including flies, fish and frogs, have unusually rapid cell cycles and delayed onset of transcription. These divisions are dependent on maternally supplied RNAs and proteins including...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (16): dev174706.
Published: 15 August 2019
... recent advances in determining MEIS function and discusses new insights into their role in the pathogenesis of solid cancers. Cell cycle Embryogenesis Epigenetic modification of chromatin MEIS PBX Post-transcriptional and posttranslational control Solid cancer Ever since their...
Journal Articles
Journal: Development
Development (2019) 146 (12): dev173476.
Published: 14 June 2019
... single cell RNA-seq and identified cell cycle gene expression as a major determinant of transcriptional variation. Within cell cycle stage-matched CMs from a given heart chamber, we found that CMs in the G2/M phase downregulated sarcomeric and cytoskeletal markers. We also identified cell location...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (8): dev173195.
Published: 23 April 2019
..., animals displayed fewer stem cells and a slower cell cycle, which combine to substantially decrease progenitor zone output. The C. elegans germline is the only adult tissue that contains stem cells, allowing the analysis of stem cells in aging. To investigate the mechanism of the decrease in stem cell...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2019) 146 (3): dev171066.
Published: 04 February 2019
... SPEECHLESS, a pair of genes, SOL1 and SOL2 , are required for effective transitions in the lineage. We show that these two genes, which are homologs of the LIN54 DNA-binding components of the mammalian DREAM complex, are expressed in a cell cycle-dependent manner and regulate cell fate and division...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (19): dev161281.
Published: 05 October 2018
... neurulation. Biomechanics Tissue architecture Tissue mechanics Cellular foam Germ layers Extracellular matrix Cell cycle Actin cross-linkers Actomyosin Morphogenesis Dissociation Centrifugation Tissue movements during development depend on mechanics. Early movements facilitate the...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2018) 145 (19): dev166678.
Published: 02 October 2018
...Nora Gigli-Bisceglia; Timo Engelsdorf; Miroslav Strnad; Lauri Vaahtera; Ghazanfar Abbas Khan; Amel Yamoune; Leila Alipanah; Ondřej Novák; Staffan Persson; Jan Hejatko; Thorsten Hamann ABSTRACT During plant growth and defense, cell cycle activity needs to be coordinated with cell wall integrity...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (17): dev166322.
Published: 28 August 2018
..., U11 loss caused elevated minor intron retention in genes regulating the cell cycle, which was consistent with fewer RGCs in S-phase and cytokinesis, alongside prolonged metaphase in RGCs. In all, we found that self-amplifying RGCs are the cell type most sensitive to loss of minor splicing. Together...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (17): dev163147.
Published: 20 August 2018
... expression profiling and cell cycle measurements indicate that shortening of the G1 and S phases in radial glial cells precedes this delay. Reduced G1 length correlates with an upregulation of the cyclin-dependent kinase gene Cdk6 , which is directly regulated by Gli3. Moreover, pharmacological interference...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2018) 145 (15): dev164376.
Published: 09 August 2018
... interactions with plant phytohormonal networks. Summary: This Primer summarizes the emerging roles of reactive oxygen species and redox-dependent mechanisms in plant growth and development, highlighting interactions with phytohormonal networks. Plants Hydrogen peroxide Redox metabolism Cell cycle...
Journal Articles
Journal: Development
Development (2018) 145 (10): dev161042.
Published: 14 May 2018
...Tokiko Furuta; Hyoe-Jin Joo; Kenneth A. Trimmer; Shin-Yu Chen; Swathi Arur ABSTRACT Adult C. elegans germline stem cells (GSCs) and mouse embryonic stem cells (mESCs) exhibit a non-canonical cell cycle structure with an abbreviated G1 phase and phase-independent expression of Cdk2 and cyclin E...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (7): dev160747.
Published: 05 April 2018
... proliferation and more rapid cell cycle speed in both Drosophila and mouse. These features contribute to anterior CNS expansion in both species. With respect to genetic control, enhanced brain proliferation is severely reduced by ectopic Hox gene expression, by either Hox misexpression or by loss of Polycomb...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2018) 145 (6): dev160671.
Published: 21 March 2018
... the question of how developmental regulators interact with the cell cycle machinery to link cell division events with particular developmental trajectories. In Arabidopsis leaves, the development of stomata, two-celled epidermal valves that mediate plant-atmosphere gas exchange, relies on a series of...
Includes: Supplementary data