...Ameya Khandekar; Stephanie J. Ellis ABSTRACT Cell competition arises in heterogeneous tissues when neighbouring cells sense their relative fitness and undergo selection. It has been a challenge to define contexts in which cell competition is a physiologically relevant phenomenon and to understand...

... permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Summary: Pluripotent cells with p53 mutations gain a competitive growth advantage via the apoptotic elimination of wild-type cells. Cell competition p53...

...Amit Kumar; Nicholas E. Baker ABSTRACT Cell competition, the elimination of cells surrounded by more fit neighbors, is proposed to suppress tumorigenesis. Mahjong (Mahj), a ubiquitin E3 ligase substrate receptor, has been thought to mediate competition of cells mutated for lethal giant larvae ( lgl...

...Sarah Bowling; Katerina Lawlor; Tristan A. Rodríguez ABSTRACT The process of cell competition results in the elimination of cells that are viable but ‘less fit’ than surrounding cells. Given the highly heterogeneous nature of our tissues, it seems increasingly likely that cells are engaged...

... is essential for cardiomyocyte proliferation and cardiogenesis. Mosaic Myc overexpression in a Mycn -deficient background shows that Myc can replace Mycn function, recovering heart development. We further show that this recovery involves the elimination of Mycn-deficient cells by cell competition. Our results...

... and highlighting JAK/STAT pathway functions in proliferation, survival and cell competition that are conserved between Drosophila and vertebrates. * Author for correspondence ( [email protected] ) Competing interests The authors declare no competing or financial interests. 10 9 2018 3 12...

...Aloma B. Rodrigues; Tamara Zoranovic; Aidee Ayala-Camargo; Savraj Grewal; Tamara Reyes-Robles; Michelle Krasny; D. Christine Wu; Laura A. Johnston; Erika A. Bach Cell competition is a conserved mechanism that regulates organ size and shares properties with the early stages of cancer. In Drosophila...

... The authors declare no competing financial interests. 15 5 2012 © 2012. 2012 Drosophila Hh Cell competition Somatic stem cell niche Testis Stem cells are specified and maintained by specific microenvironments called niches. The niches in the fly testis and ovary harbour...

...Francisco A. Martín; Salvador C. Herrera; Ginés Morata We report here experiments aimed at understanding the connections between cell competition and growth in the Drosophila wing disc. The principal assay has been to generate discs containing marked cells that proliferate at different rates...

...Christa Rhiner; Begoña Díaz; Marta Portela; Juan F. Poyatos; Irene Fernández-Ruiz; Jesús M. López-Gay; Offer Gerlitz; Eduardo Moreno Cell competition is a short-range cell-cell interaction leading to the proliferation of winner cells at the expense of losers, although either cell type shows...

...-mail: [email protected] ) 11 7 2005 ©2005. 2005 Stem cell Hair follicle Morphogenesis Cell lineage Cell behavior Clonal analysis Mouse Temporally induced clones Apoptosis Anagen Cell competition Developmental strategy The hair follicle (HF) is a fascinating model...