... and GFP specifically in Plap-1 -positive PDLCs. Genetic lineage tracing confirmed the long-standing hypothesis that PDLCs differentiate into osteoblasts and cementoblasts. A PDL single-cell atlas defined cementoblasts and osteoblasts as Plap-1 − Ibsp + Sparcl1 + and Plap-1 − Ibsp + Col11a2...

.... Human development Cell atlas Model systems Over the past ∼25 years, a remarkable amount of progress has been made in the ability to culture human embryonic stem cells (hESCs) or reprogram cells into an induced pluripotent state (hPSCs). These stem cells can be used to recreate aspects...

... development Ectodermal organs Patterning Cell atlas Gene regulatory networks Single cell RNA-sequencing National Institute of Dental and Craniofacial Research http://dx.doi.org/10.13039/100000072 R90DE031531 R00DE025874 R03DE030205 University of California, Los Angeles http...

... of Biologists Ltd 2019 Summary: This Hypothesis proposes a periodic table that aligns cell types according to their developmental stages, connecting them to one another according to the universal axis from stem cells to differentiated cells. Cell atlas Cell states Cell types Periodic table...