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Keywords: Cell Survival
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Journal Articles
Journal: Development
Development (2018) 145 (20): dev164046.
Published: 24 October 2018
... binds to LTK. Taken together, these results suggest that LTK in neural crest cells interacts with midkine emanating from the non-neural ectoderm to promote cell survival, revealing a new signaling pathway that is essential for neural crest development. * Author for correspondence ( mbronner...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (20): dev164046.
Published: 24 October 2018
... binds to LTK. Taken together, these results suggest that LTK in neural crest cells interacts with midkine emanating from the non-neural ectoderm to promote cell survival, revealing a new signaling pathway that is essential for neural crest development. In an effort to identify novel signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (9): dev156018.
Published: 25 April 2018
... ). By contrast, both full-length and cleaved DNT1, DNT2 and mammalian NTs can induce signalling to elicit distinct functions, such as cell death versus cell survival, respectively ( Foldi et al., 2017 ; Lu et al., 2005 ). Toll/TLRs harbour an N-terminal extracellular ligand-binding domain that contains...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2016) 143 (16): 2907–2919.
Published: 15 August 2016
... damage, JAK/STAT signalling and its effector Zfh2 promote the survival of JNK-signalling cells in Drosophila imaginal discs, thereby limiting tissue damage and facilitating systemic responses. JAK/STAT JNK Cell survival Compensatory proliferation Cancer Injury-induced apoptosis Eiger Cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (24): 5379–5391.
Published: 15 December 2011
... interests statement The authors declare no competing financial interests. 9 9 2011 © 2011. Drosophila Cell proliferation Cell survival Hematopoietic colonization Hematopoiesis Hemocyte Larva Microenvironment Peripheral nervous system W1118 or yw...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (13): 2321–2329.
Published: 1 July 2008
... with conditional loss- and gain-of-β-catenin function, clearly demonstrate that β-catenin has a role early in cell survival and later in the cell specification of ventral dermal progenitors. In this study, by eliminating β-catenin early in the LPM, we found a role forβ-catenin in early cell survival before E10.5...
Journal Articles
Journal: Development
Development (2007) 134 (7): 1443–1451.
Published: 1 April 2007
... upregulation, in addition to being necessary for the nuclear translocation of Mdm2. Inhibition of either mTOR or Mdm2 is sufficient to block cell survival induced by Hgf-Met in vitro. Moreover, in vivo inhibition of mTOR downregulates Mdm2 protein levels and induces p53-dependent apoptosis. Our studies...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (23): 4771–4781.
Published: 1 December 2006
... concerning the genes required for survival during the early cell-proliferation phase. Here, we show that Lobe ( L ) and the Notch (N) ligand Serrate ( Ser ), which are both involved in ventral eye growth, are required for cell survival in the early eye disc. We observed that the loss-of-ventral-eye phenotype...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (12): 2435–2445.
Published: 15 June 2006
...,2005 ; Meyers and Martin,1999 ). Third, Fgf8 is required for migratory cardiac neural crest cell survival, and therefore OT septation defects could arise from neural crest cell deficiencies( Abu-Issa et al., 2002 ; Macatee et al., 2003 ). Finally, Fgf8 is expressed in the precardiac SM as early...
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2006) 133 (3): 517–528.
Published: 1 February 2006
... dependent transcription affected cell survival. We transfected a deleted form of Gli3 (Gli3R) that contains the N-terminal repressor and the zinc-finger, DNA-binding domains that are equivalent to the proposed proteolytically processed form of Gli3( Wang et al., 2000 ). In vitro,Gli3R blocks all Shh/Gli...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (18): 4545–4553.
Published: 15 September 2004
... cells and pole cell-specific expression of wun2 rescued the pole cell death phenotype of the maternal wun2 mutant, suggesting that wun2 activity in pole cells is required for their survival. Furthermore, we obtained genetic evidence that pole cell survival requires a proper balance of LPP activity...
Journal Articles
Journal Articles
Journal: Development
Development (2003) 130 (20): 4919–4929.
Published: 15 October 2003
... and glypican. J. Cell Biol. 133 , 405 -416. Storm, E. E., Rubenstein, J. L. and Martin, G. R. ( 2003 ). Dosage of Fgf8 determines whether cell survival is positively or negatively regulated in the developing forebrain. Proc. Natl. Acad. Sci. USA 100 , 1757 -1762. Topczewski, J., Sepich, D. S...
Journal Articles
Journal: Development
Development (2001) 128 (20): 4011–4020.
Published: 15 October 2001
... counteract a built-in cell death program and thereby contribute to organ morphogenesis, in particular in the central nervous system. *Author for correspondence (e-mail: teillet@infobiogen.fr ) 19 7 2001 © 2001. 2001 Apoptosis Avian embryo Cell death Cell survival Floor plate...
Journal Articles
Journal Articles
Journal: Development
Development (2001) 128 (2): 207–216.
Published: 15 January 2001
... Connectives Glia Cell survival Drosphila melanogaster CNS Flies, like vertebrates, are bilateral symmetrical organisms, in which the two sides are separated by the midline. The fly ventral nerve cord (VNC) of the central nervous system (CNS) extends along the main body axis, like the spinal cord...
Journal Articles