..., suggesting that Rspo2 functions upstream of Mek1. The observed inhibition of FGF signaling was accompanied by the downregulation of the FGF target genes tbxt/brachyury and cdx4 , which mediate anterioposterior axis specification. Importantly, these target genes were upregulated in Rspo2-depleted explants...

...Mary D. Kinkel; Stefani C. Eames; Martha R. Alonzo; Victoria E. Prince Cdx transcription factors have crucial roles in anteroposterior patterning of the nervous system and mesoderm. Here we focus on the role of cdx4 in patterning the endoderm in zebrafish. We show that cdx4 has roles in determining...

... Retinoids Retinoic acid Teratogenesis Spina bifida Caudal regression Cyp26a1 RARγ Wnt3a Brachyury Fgf8 Hnf3b Cdx4 Hoxd11 Tbx6 Raldh2 Retinoic acid (RA), a biologically active metabolite of vitamin A(retinol), is a signaling molecule required for normal embryogenesis...