...Tanya E. Foley; Bradley Hess; Joanne G. A. Savory; Randy Ringuette; David Lohnes ABSTRACT Murine cardiac and hematopoietic progenitors are derived from Mesp1 + mesoderm. Cdx function impacts both yolk sac hematopoiesis and cardiogenesis in zebrafish, suggesting that Cdx family members regulate...

...Oraly Sanchez-Ferras; Guillaume Bernas; Omar Farnos; Aboubacrine M. Touré; Ouliana Souchkova; Nicolas Pilon Numerous studies in chordates and arthropods currently indicate that Cdx proteins have a major ancestral role in the organization of post-head tissues. In urochordate embryos, Cdx loss...

... 9 2014 © 2014. Published by The Company of Biologists Ltd 2014 Retinoic acid cdx Hindbrain Spinal cord Patterning Head-trunk transition Craniovertebral junction Zebrafish References Aulehla , A. and Pourquié , O. ( 2010 ). Signaling gradients during...

...Joanne G. A. Savory; Melissa Mansfield; Filippo M. Rijli; David Lohnes The vertebrate Cdx genes ( Cdx1, Cdx2 and Cdx4 ) encode homeodomain transcription factors with well-established roles in anteroposterior patterning. To circumvent the peri-implantation lethality inherent to Cdx2 loss of function...

... Cdx Vertebral patterning Axis elongation Brachyury Wnt3a Retinoic acid CYP26a1 Mouse Cdx2 -null mutants exhibited reduced expression of Cdx4. As Cdx members exhibit extensive functional overlap, at least as regards vertebral patterning ( van den Akker et al., 2002 ; Savory et al...

...Stephen J. Gaunt; Deborah Drage; Richard C. Trubshaw To investigate the link between Cdx protein concentration and axial patterning in embryos, we made lines of mice OE1, OE2 and OE4 that overexpress each of the Cdx genes Cdx1 , Cdx2 and Cdx4 ,respectively. The lines carry Cdx transgenes under...

... identified Cdx transcription factors as key determinants of the spinal cord region in zebrafish. Loss of Cdx1a and Cdx4 functions causes posterior expansion of the hindbrain at the expense of the unsegmented spinal cord. By contrast, cdx4 overexpression in the hindbrain impairs rhombomere segmentation...

...Johan van Nes; Wim de Graaff; Franck Lebrin; Markus Gerhard; Felix Beck; Jacqueline Deschamps Caudal related homeobox (Cdx) genes have so far been shown to be important for embryonic axial elongation and patterning in several vertebrate species. We have generated a targeted mutation of mouse Cdx4...

... phenotypes Vertebral phenotype Mutant BO/Vertebra 1 Vertebra 2 Vertebra 3 NA fusion RARE - C2 to C1 - - Cdx Always fused, reduced C1 NA and indistinct AAA C2 to C1 C3 to C2 C2 and C3 fusion Hoxa3 - - - - Hoxb3 - - - - Hoxd3 BO enlarged, indistinct AAA...

...), cad must act combinatorially with these two genes to promote early fkh expression. There is thus a constellation of conserved genes – cad (Cdx), fkh (HNF-3), wg (Wnt8 and Wnt11) and byn (Brachyury) – whose overlapping expression patterns in the blastopore equivalent suggests function...

...’ activity proposed by Nieuwkoop in his ‘activation and transformation’ model for neural patterning. * Author for correspondence 18 09 1996 © 1996 by Company of Biologists 1996 fibroblast growth factor caudal cdx anteroposterior specification Hox genes Xenopus...