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Keywords: Cdk4
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Journal Articles

The Cdk4-E2f1 pathway regulates early pancreas development by targeting Pdx1 + progenitors and Ngn3 + endocrine precursors

So Yoon Kim, Sushil G. Rane
Journal: Development
Development (2011) 138 (10): 1903–1912.
https://doi.org/10.1242/dev.061481
Published: 15 May 2011
... division and is required for the first embryonic divisions, whereas Cdks 2, 4 and 6 are dispensable for organogenesis but vital for tissue-specific cell development. Here, we illustrate an important role for Cdk4 in regulating early pancreas development. Pancreatic development involves extensive...
View article titled, The <span class="search-highlight">Cdk4</span>-E2f1 pathway regulates early pancreas development by targeting Pdx1 + progenitors and Ngn3 + endocrine precursors
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Includes: Multimedia, Supplementary data
Journal Articles

Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a jumonji (Jarid2)-cyclin D1 pathway

Kuniko Nakajima, Masayo Inagawa, Chiharu Uchida, Kumiko Okada, Shoji Tane, Mizuyo Kojima, Misae Kubota, Masatsugu Noda, Satoko Ogawa, Haruki Shirato, Michio Sato, Rika Suzuki-Migishima, Toshiaki Hino, Yukio Satoh, Masatoshi Kitagawa, Takashi Takeuchi
Journal: Development
Development (2011) 138 (9): 1771–1782.
https://doi.org/10.1242/dev.059295
Published: 1 May 2011
... decreased GATA4 protein expression and inhibited the differentiation of cardiomyocytes in a CDK4/6-dependent manner, and that exogenous expression of GATA4 rescued the abnormal differentiation. Finally, CDK4 phosphorylated GATA4 directly, which promoted the degradation of GATA4 in cultured cells...
View article titled, Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a jumonji (Jarid2)-cyclin D1 pathway
Open the PDF for Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a jumonji (Jarid2)-cyclin D1 pathway in another window
Includes: Supplementary data