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Keywords: Cdk1
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Journal Articles
Journal: Development
Development dev.200351.
Published: 12 May 2022
... activity of PLK1 when cells exhibit DNA lesions which inhibited CHK2 and upregulated the activation of CDK1, resulting in inefficient loading of essential HR factor RAD51. On the other hand, if inhibiting PLK1 in the S phase, DNA end resection was restricted. These results demonstrate that PPP4C...
Journal Articles
Journal: Development
Development (2014) 141 (17): 3388–3398.
Published: 1 September 2014
... cells requires the nuclease DNase IIβ (DLAD) but the mechanism by which DLAD gains access to nuclear DNA remains unknown. In eukaryotic cells, cyclin-dependent kinase 1 (CDK1), in combination with either activator cyclins A or B, stimulates mitotic entry, in part, by phosphorylating the nuclear lamin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (3): 547–557.
Published: 1 February 2012
...@snv.jussieu.fr ) Competing interests statement The authors declare no competing financial interests. 23 11 2011 © 2012. Endocycle Cyclin A ORC2 Cdk1 Neural development Drosophila Endocycles arise from drastic modifications of the canonical G1-S-G2-M cell...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (4): 697–709.
Published: 15 February 2006
... maturation Myt1 Wee1 Cdk1 Oocyte growth and differentiation (oogenesis) are crucial for fertilization competency and the rapid cell divisions of early embryonic development. The developing oocyte is essentially a synthetic factory and maternal storehouse for the factors required...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (18): 4075–4085.
Published: 15 September 2005
...Zhigang Jin; Ellen M. Homola; Philip Goldbach; YunHee Choi; Julie A. Brill; Shelagh D. Campbell The metazoan Wee1-like kinases Wee1 and Myt1 regulate the essential mitotic regulator Cdk1 by inhibitory phosphorylation. This regulatory mechanism, which prevents Cdk1 from triggering premature mitotic...