... pool is rapidly lost. We identify two conserved Pdx1 binding sites in the epithelial cadherin ( E-cad , Cdh1 ) promoter, and show that Pdx1 directly binds and activates E-cad transcription. In addition, Pdx1 is required in vivo for maintenance of E-cad expression, actomyosin complex activity and cell...

... to spermatogenesis . Development 129 , 1155 – 1164 . Almeida A. , Bolaños J. P. , Moreno S. ( 2005 ). Cdh1/Hct1-APC is essential for the survival of postmitotic neurons . J. Neurosci. 25 , 8115 – 8121 . Baleato R. M. , Aitken R. J. , Roman S. D. ( 2005 ). Vitamin...

... Cdh1 Cdx2 Yap PKCzeta Jam1 Lgl Par6 P-cadherin Mouse At E3.5, the mouse embryo consists of two cell types, the outside trophectoderm (TE), which generates the embryonic portion of the placenta, and the inner cell mass (ICM), which later forms the embryo itself...

... in the concentrations of the Cdk1-binding partner cyclin B1, a process achieved by anaphase-promoting complex (APC Cdh1 ) activity, which ubiquitylates and so targets cyclin B1 for degradation. Thus, APC Cdh1 activity prevents precocious meiotic entry by promoting cyclin B1 degradation. However, it remains unresolved...

... is modified to transform a mitotic cycle into endocycle has long been a matter of interest. In both plants and animals, the transition from the mitotic cycle to the endocycle requires Fzr/Cdh1, a positive regulator of the Anaphase-Promoting Complex/Cyclosome (APC/C). However, because many of its targets...