1-15 of 15
Keywords: Cdc42
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
Journal: Development
Development (2021) 148 (2): dev196360.
Published: 21 January 2021
... development. Here, we show that Ror2-mediated non-canonical Wnt signaling in the dental mesenchyme plays a crucial role in cell proliferation, and thereby regulates root development size in mouse molars. Furthermore, Cdc42 acts as a potential downstream mediator of Ror2 signaling in root formation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (15): dev175497.
Published: 12 August 2019
...Francisca Nunes de Almeida; Rhian F. Walther; Mary T. Pressé; Evi Vlassaks; Franck Pichaud ABSTRACT Cdc42 regulates epithelial morphogenesis together with the Par complex (Baz/Par3-Par6-aPKC), Crumbs (Crb/CRB3) and Stardust (Sdt/PALS1). However, how these proteins work together and interact during...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (13): dev161182.
Published: 02 July 2018
... interplay during development and their relative importance for vascular pathologies remain poorly understood. Here, we investigated the endothelial functions regulated by Cdc42 and their in vivo relevance during angiogenic sprouting and vascular morphogenesis in the postnatal mouse retina. We found that...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (11): 1937–1947.
Published: 01 June 2017
... differentiation requires dynamic interactions with somatic escort cells. This involves a complex meshwork of escort cell protrusions and is regulated by multiple signalling pathways. Germline stem cells Escort cells Drosophila Stat Erk Rho Cdc42 Protrusion Balancing stem cell maintenance...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (9): 1635–1647.
Published: 01 May 2017
... their subsequent translocation to the heart to form the epicardium. We used lineage tracing, conditional deletion, mosaic analysis and ligand stimulation in mice to determine that both villous protrusions and floating cysts contribute to PEC translocation to myocardium in a CDC42-dependent manner. We...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (22): 4173–4181.
Published: 15 November 2016
... tubulogenesis by regulating F-actin at the tip of the growing canal and the dynamics of basolateral microtubules. EXC-6 functions in parallel with EXC-5/FGD, a predicted activator of the Rho GTPase Cdc42. Here, we identify the parallel pathway: EXC-5 functions through CDC-42 to regulate two other formins: INFT...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (17): 3058–3070.
Published: 01 September 2015
... remain unclear. Here, we assess the cellular mechanisms by which Cdc42 regulates mammalian vascular morphogenesis and maintenance. In vivo deletion of Cdc42 in embryonic ECs (Cdc42 Tie2KO ) results in blocked lumen formation and endothelial tearing, leading to lethality of mutant embryos by E9-10 due to...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (3): 685–696.
Published: 01 February 2014
..., which are controlled by Cdc42/N-WASP signaling. Specifically, we show that expression of constitutively active Cdc42 in β cells inhibits β cell delamination and differentiation. These processes are normally associated with junctional actin and cell-cell junction disassembly and the expression of fate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (15): 3139–3145.
Published: 01 August 2013
...Kei-ichi Katayama; Fumiyasu Imai; Kenneth Campbell; Richard A. Lang; Yi Zheng; Yutaka Yoshida Cortical interneurons arise from the ganglionic eminences in the ventral telencephalon and migrate tangentially to the cortex. Although RhoA and Cdc42, members of the Rho family of small GTPases, have been...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (2): 362–371.
Published: 15 January 2013
..., no upstream regulator or mechanism for localization of the Par proteins in the oocyte has been identified. We have analyzed the role of the small GTPase Cdc42 in oocyte polarity. We show that Cdc42 is required to maintain oocyte fate, which it achieves by mediating localization of Par proteins at...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (1): 13–21.
Published: 01 January 2013
...; the second is the requirement for mutual antagonism between determinants that localise to opposite ends of the cell. Cdc42 Crumbs Lgl PAR Cell polarity Epithelia Cell polarity is a fundamental feature of almost all cells. Different cell types employ polarity to orient their...
Journal Articles
Journal: Development
Development (2010) 137 (24): 4177–4189.
Published: 15 December 2010
... Cdc42 and Merlin act together with Pak1 to control lumen size. A role for Pak1 in E-cadherin endocytosis is supported by our studies of constitutively active Pak1, which induces the formation of multiple intercellular lumens in the salivary gland in a manner dependent on Rab5, Dynamin and Merlin. These...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (23): 4101–4110.
Published: 01 December 2010
... one another. These interactions are mediated by growth cone-like endfeet and filopodia-like protrusions. Polarized expression of the cell polarity regulator Cdc42 in radial glia regulates glial endfeet activities and inter-radial glial interactions. Furthermore, appropriate regulation of Gsk3 activity...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (21): 3657–3667.
Published: 01 November 2009
... retracted by E11.5 when invagination is complete. At E10.5 -the lens pit stage - there is approximately one filopodium per epithelial cell. Formation of filopodia is dependent on the Rho family GTPase Cdc42 and the Cdc42 effector IRSp53 (Baiap2). Loss of filopodia results in reduced lens pit invagination...
Journal Articles
Journal: Development
Development (2002) 129 (22): 5227–5239.
Published: 15 November 2002
... reversed by co-expression of a dominant negative form of Cdc42 that has been suggested to mediate the planar cell polarity pathway of Wnt; and (4) the ectodomain of Xror2 interacts with Xwnts in co-immunoprecipitation experiments. These results suggest that Xror2 cooperates with Wnts to regulate convergent...