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Keywords: Cdc25
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Journal Articles
Journal: Development
Development (2011) 138 (23): 5079–5086.
Published: 1 December 2011
... the cell cycle of stem cells remain poorly understood. Here, we show that the Cdc25 homolog String (Stg) is a crucial regulator of germline stem cells (GSCs) and cyst stem cells (CySCs) in Drosophila testis. Through knockdown and overexpression experiments, we show that Stg is required for stem cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (22): 3697–3706.
Published: 15 November 2008
... of cdc2 (synonymous with cdk1 ) and of twine , the meiotic homolog of cdc25, which is required for Cdk1 activation. We found that Twine and Polo kinase levels are reduced in endos mutants, and identified Early girl (Elgi), a predicted E3 ubiquitin ligase, as a strong Endos-binding protein. In elgi mutant...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (18): 4075–4085.
Published: 15 September 2005
... in myt1 females ( Table 3 , cross 2). These data demonstrate that loss of Myt1activity compromises female meiosis, specifically meiosis I. Myt1 Wee1 Cdk1 Cdc25 Meiosis Mitosis Spermatogenesis Oogenesis A conserved molecular mechanism that controls entry into mitosis in eukaryotic...
Journal Articles
Journal: Development
Development (2004) 131 (7): 1543–1552.
Published: 1 April 2004
... of oogenesis). Stage IV oocytes contain a store of inactive pre-MPF (Tyr15-phosphorylated Cdc2 bound to cyclin B2); the Cdc25 phosphatase that catalyzes Tyr15 dephosphorylation of Cdc2 is also present. However, the positive feedback loop that allows MPF autoamplification is not functional at this stage...
Journal Articles
Journal: Development
Development (2002) 129 (9): 2155–2165.
Published: 1 May 2002
... specification through Wnt signaling makes cells susceptible to the cdc-25.1(gf) mutation, although at present we cannot discern whether this is a direct or indirect effect. It has been shown that in other systems Wnt does affect cell division through effects on Cdc25 ( Johnston and Edgar, 1998 ; Rimerman et...