... for the expression of the spider orthologues of even-skipped ( eve ) and runt-1 ( run-1 ), at least in part via caudal ( cad ). Moreover, it appears that dynamic expression of eve in this spider does not require a feedback loop with run-1 , as is found in the pair-rule circuit of the beetle Tribolium . Taken...

... of a specific set of neuroblasts in parasegment 15 (including NB7-3). We further show that Abd-B.r requires cooperation of the ParaHox gene caudal to unfold its full competence concerning neuroblast inhibition and specification. Thus, our findings demonstrate that combined action of Abdominal-B and caudal...

... mechanisms is highly controversial. The caudal domain transcription factor CDX2 has been reported to act as a maternal determinant regulating cell fate decisions in mouse development. However, this finding is contentious because of reports that maternal Cdx2 is not essential for development. Notably, all...

...Haiyan Lei; Jun Liu; Tetsunari Fukushige; Andrew Fire; Michael Krause Previous work in C. elegans has shown that posterior embryonic bodywall muscle lineages are regulated through a genetically defined transcriptional cascade that includes PAL-1/Caudal-mediated activation of muscle-specific...

...Isaac Skromne; Dean Thorsen; Melina Hale; Victoria E. Prince; Robert K. Ho The spinal cord is a unique vertebrate feature that originates, together with the hindbrain, from the caudal neural plate. Whereas the hindbrain subdivides into rhombomeres, the spinal cord remains unsegmented. We have...

... interference (RNAi) revealed that Gryllus byn ( Gb ' byn ) is not required for AP axial elongation or normal segment formation, but is required for specification of the posterior gut. We also analyzed Gryllus caudal ( Gb ' cad ) RNAi embryos using in situ hybridization with a Gb ' byn probe, and found that Gb...

... , a gradient of localized caudal mRNA directs posterior patterning, whereas, in Drosophila , the gradient of maternal Caudal protein is established through translational repression by Bicoid of homogeneous caudal mRNA. Loss of caudal function in Nasonia results in severe segmentation defects. We show...

... in the embryo of the African plague locust Schistocerca gregaria, an orthopteran insect that displays a mode of embryogenesis very different from that of Drosophila . Transcripts of the caudal gene are expressed maternally and are present in all cells that aggregate to form the early embryonic rudiment. First...

... mutations because unfertilized eggs develop as males while fertilized eggs develop as females. Here we describe recessive zygotic mutations identifying three Nasonia genes: head only mutant embryos have posterior defects, resembling loss of both maternal and zygotic Drosophila caudal function; headless...

... addition during insect evolution. We addressed this question by analysing the regulation of potential target genes of bicoid in the short germ embryo of Tribolium castaneum . We demonstrate that homologues of caudal and hunchback from Tribolium are regulated by Drosophila bicoid . In Drosophila , maternal...

...Linda H. Wu; Judith A. Lengyel ABSTRACT During early embryogenesis in Drosophila, caudal mRNA is distributed as a gradient with its highest level at the posterior of the embryo. This suggests that the Caudal homeodomain transcription factor might play a role in establishing the posterior domains...

... determined the molecular basis of this phenotype and we propose a role for eFGF in normal anteroposterior patterning. In this study, we show that the overexpression of eFGF causes the up-regulation of a number of posteriorly expressed genes, and prominent among these are Xcad3 , a caudal homologue...

...Cordula Schulz; Diethard Tautz ABSTRACT caudal ( cad ) is a maternally and zygotically expressed gene in Drosophila whereby the two phases of expression can functionally replace each other. The zygotic expression forms an abdominal and a posterior domain, whereby only the posterior domain has so...

... the embryonic axes. Furthermore, the expression correlates with the formation of segmented tissue in the posterior hindbrain, the spinal cord and structures like the mesonephros. 08 Octobe 1992 © 1993 by Company of Biologists 1993 Cdx-1 homeobox caudal primitive streak gastrulation...

...Ayala Frumkin; Zehava Rangini; Adi Ben-Yehuda; Yosef Gruenbaum; Abraham Fainsod ABSTRACT CHox-cad is a chicken homeobox gene whose homeo domain is homologous to the Drosophila caudal and the murine Cdx1 genes. Based on sequence analysis of a 2.5 kb CHox-cad cDNA clone, we deduced that the primary...

...Marek Mlodzik; Greg Gibson; Walter J. Gehring ABSTRACT The effects of heat-shock-induced ectopic expression of the homeobox gene caudal (cad) at all stages of Drosophila development have been examined. Presence of cad protein (CAD) at the anterior end of cellular blastoderm embryos was found...