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Keywords: Caspase
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Journal Articles
Journal: Development
Development (2020) 147 (14): dev191882.
Published: 24 July 2020
... abnormalities and pathological cell death in disease. Perhaps the strongest evidence that lysosomes promote developmental cell death comes from studies of Drosophila germ cells. Here, the initiator caspase Dronc is required, independently of Dark or effector caspases, to promote lysosome membrane...
Journal Articles
Journal: Development
Development (2020) 147 (7): dev179648.
Published: 14 April 2020
.... Endocytic activity gradually reduces as tissue remodeling progresses. This reduced endocytic activity accelerates cell elimination through the regulation of Myosin II subcellular reorganization, junctional E-cadherin levels, and caspase activation. Whereas the increased Myosin II dynamics accelerates cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (5): dev179606.
Published: 11 March 2020
... result in apoptotic extrusion of LECs during early pupal development. Extrusion of cells is closely preceded by caspase activation and is executed by contraction of a cortical actomyosin cable. Here, we identify a population of LECs that extrudes independently of the presence of histoblasts during late...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2016) 143 (12): 2147–2159.
Published: 15 June 2016
... to maintain a balance of dendritic growth and retraction in class IV da neurons and that upregulation of hid results in decreased branching because of an increase in caspase activity. The temporal requirement for nos correlates with an ecdysone-triggered switch in sensitivity to apoptotic stimuli that occurs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (8): 1493–1499.
Published: 15 April 2011
... when the activity of caspases or JNK or PVF/PVR signaling was reduced. Acceleration was induced by two distinct subcompartments of the A8 segment that formed a ring shape and surrounded the male genitalia: the inner ring rotated with the genitalia and the outer ring rotated later, functioning...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (2): 327–338.
Published: 15 January 2011
... dynamics during germline cell death in the Drosophila melanogaster ovary. We find that mitochondria undergo a series of events during the progression of cell death, with remodeling, cluster formation and uptake of clusters by somatic follicle cells. These mitochondrial dynamics are dependent on caspases...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (10): 1679–1688.
Published: 15 May 2010
..., is facilitated by the apoptotic machinery, including caspases, but does not result in cell death. From a screen for genes defective in caspase activation in this system, we isolated a novel F-box protein, which we termed Nutcracker, that is strictly required for caspase activation and sperm differentiation...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2005) 132 (9): 2125–2134.
Published: 1 May 2005
...Dongbin Xu; Ying Li; Michael Arcaro; Melinda Lackey; Andreas Bergmann The initiator caspase Dronc is the only Drosophila caspase that contains a caspase activation and recruitment domain (CARD). Although Dronc has been implicated as an important effector of apoptosis, the genetic function of dronc...
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2002) 129 (13): 3269–3278.
Published: 1 July 2002
...Sun-Yun Yu; Soon Ji Yoo; Lihui Yang; Cynthia Zapata; Anu Srinivasan; Bruce A. Hay; Nicholas E. Baker Regulated cell death and survival play important roles in neural development. Extracellular signals are presumed to regulate seven apparent caspases to determine the final structure of the nervous...
Journal Articles
Journal Articles