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Keywords: Cartilage
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Journal Articles
Journal: Development
Development (2021) 148 (16): dev197244.
Published: 16 August 2021
...D'Juan T. Farmer; Punam Patel; Rachelle Choi; Chih-Yu Liu; J. Gage Crump ABSTRACT Proper function of the vertebrate skeleton requires the development of distinct articulating embryonic cartilages. Irx transcription factors are arranged in co-regulated clusters that are expressed in the developing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (13): dev198192.
Published: 06 July 2021
... than those of mice ( Hogan et al., 2014 ). The cartilage and basal cells are only present in the trachea and the main branch in mice but these components expand to bronchioles in humans. The diameter of the mouse trachea (−1.5 mm) is equivalent to that of the human bronchioles. In addition...
Journal Articles
Journal: Development
Development (2021) 148 (7): dev197483.
Published: 15 April 2021
...Jennyfer M. Mitchell; Juliana Sucharov; Anthony T. Pulvino; Elliott P. Brooks; Austin E. Gillen; James T. Nichols ABSTRACT During craniofacial development, different populations of cartilage- and bone-forming cells develop in precise locations in the head. Most of these cells are derived from...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (21): dev187187.
Published: 12 November 2020
..., but can also control cell fate or tissue morphogenesis. Here, we investigate the function of the Hippo pathway during the development of cartilage, which forms the majority of the skeleton. Previously, YAP was proposed to inhibit skeletal size by repressing chondrocyte proliferation and differentiation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (11): dev190488.
Published: 11 June 2020
... of chondrocytes in Meckel's cartilage to drive jaw outgrowth, however the specific factors controlling this process remain unknown. Here, we use in vitro and ex vivo cell and tissue culture, as well as genetic mouse models, to identify IGF1 as a novel angiocrine factor directing Meckel's cartilage growth during...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (14): dev167882.
Published: 26 July 2019
... Article: The development of protrusions, such as eminences and condyles, along long bones in mice is coordinated by a patterning mechanism involving global and regional genetic regulation. Cartilage Patterning Morphology Superstructure Sox9 Scleraxis Modularity Gli3 Pbx Hox Mouse...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (3): dev171496.
Published: 11 February 2019
... during foregut development. Here, we found that ablation of the Wnt chaperone protein Gpr177 (also known as Wntless) in mouse tracheal epithelium causes a significant reduction in the number of basal progenitor cells accompanied by cartilage loss in Shh-Cre;Gpr177 loxp/loxp mutants. Consistent...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (14): dev164780.
Published: 26 July 2018
... visualization of Alcian Blue-stained lamprey cellular cartilage bars is described elsewhere ( Martin et al., 2009 ). Image stacks of fluorescent lamprey cartilage and high-magnification Hu immunostaining of cranial sensory ganglia were rendered as maximum intensity projections using the Inside 4D module...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (12): dev165498.
Published: 26 June 2018
...Pengfei Xu; Bartosz Balczerski; Amanda Ciozda; Kristin Louie; Veronika Oralova; Ann Huysseune; J. Gage Crump ABSTRACT Facial form depends on the precise positioning of cartilage, bone, and tooth fields in the embryonic pharyngeal arches. How complex signaling information is integrated to specify...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev156588.
Published: 08 January 2018
... achondrogenesis type 1A (ACG1A). ACG1A is surprisingly tissue specific, mainly affecting cartilage development. Bone development is also abnormal, but as chondrogenesis and osteogenesis are closely coupled, this could be a secondary consequence of the cartilage defect. A possible explanation for the tissue...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (24): 4510–4521.
Published: 15 December 2017
..., we established a role for lncRNAs in chondrocyte differentiation. Using RNA sequencing we identified a human articular chondrocyte repertoire of lncRNAs from normal hip cartilage donated by neck of femur fracture patients. Of particular interest are lncRNAs upstream of the master chondrocyte...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (19): 3562–3577.
Published: 01 October 2017
...Björn Bluhm; Harald W. A. Ehlen; Tatjana Holzer; Veronika S. Georgieva; Juliane Heilig; Lena Pitzler; Julia Etich; Toman Bortecen; Christian Frie; Kristina Probst; Anja Niehoff; Daniele Belluoccio; Jocelyn Van den Bergen; Bent Brachvogel Cartilage originates from mesenchymal cell condensations...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (19): 3533–3546.
Published: 01 October 2017
... rescued the mutant phenotype of premature cartilage maturation, thereby indicating that IGF2 controls bone growth by regulating glucose metabolism in chondrocytes. This work links glucose metabolism with cartilage development and provides insight into the fundamental understanding of human growth...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (16): 2994–3005.
Published: 15 August 2017
.... Cell   35 , 358 - 365 . 10.1016/j.devcel.2015.10.004 Barske , L. , Askary , A. , Zuniga , E. , Balczerski , B. , Bump , P. , Nichols , J. T. and Crump , J. G. ( 2016 ). Competition between Jagged-Notch and endothelin1 signaling selectively restricts cartilage...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (15): 2798–2809.
Published: 01 August 2017
...(UAS:Kaede) embryos using a picospritzer III (Parker) microinjector. Double transgenic ( Tg(Ubi:Zebrabow) ) and Tg(Sox10:Cre) zebrafish larvae express a variety of different fluorescent protein combinations in the cells of the developing cartilage. This allows individual cells to be tracked...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (16): 2946–2957.
Published: 15 August 2016
...Thomas P. Lozito; Rocky S. Tuan Lizards are amniotes with the remarkable ability to regenerate amputated tails. The early regenerated lizard tail forms a blastema, and the regenerated skeleton consists of a cartilage tube (CT) surrounding the regenerated spinal cord. The proximal, but not distal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (6): 1023–1027.
Published: 15 March 2015
...Paolo Bianco; Pamela G. Robey Skeletal stem cells (SSCs) reside in the postnatal bone marrow and give rise to cartilage, bone, hematopoiesis-supportive stroma and marrow adipocytes in defined in vivo assays. These lineages emerge in a specific sequence during embryonic development and post natal...
Journal Articles
Journal: Development
Development (2014) 141 (14): 2848–2854.
Published: 15 July 2014
...Jianquan Chen; Fanxin Long Much of the mammalian skeleton is derived from a cartilage template that undergoes rapid growth during embryogenesis, but the molecular mechanism of growth regulation is not well understood. Signaling by mammalian target of rapamycin complex 1 (mTORC1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (3): 629–638.
Published: 01 February 2014
... three-dimensional elements connected by joints. By contrast, the head skeleton of modern jawless vertebrates (agnathans) consists of thin rods of flexible cellular cartilage, a condition thought to reflect the ancestral vertebrate state. To better understand the origin and evolution of the gnathostome...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (13): 2765–2775.
Published: 01 July 2013
... that ectopic joints develop at the expense of cartilage. Time-lapse experiments suggest that barx1 controls the skeletal precursor cell choice between differentiating into cartilage versus joint cells. We discovered that barx1 functions in this choice, in part, by regulating the transcription factor hand2. We...
Includes: Supplementary data