... Competing interests The authors declare no competing or financial interests. 16 9 2024 17 1 2025 © 2025. Published by The Company of Biologists 2025 https://www.biologists.com/user-licence-1-1/ Summary: A computational model of cardiomyocyte proliferation is developed...

... Summary: Untangling the drivers of human cardiomyocyte proliferation can stimulate cardiac regenerative approaches. This Review compares in vivo heart growth pathways with the molecular targets promoting in vitro cardiomyocyte proliferation. Cardiomyocyte proliferation Cardiomyocyte production...

... cardiac regeneration. Here, we report that the forkhead transcription factor Foxm1 is required for cardiomyocyte proliferation after injury through transcriptional regulation of cell cycle genes. Transcriptomic analysis of injured zebrafish hearts revealed that foxm1 expression is increased in border zone...

... , M. J. , Lagor , W. R. , Wehrens , X. H. T. , Martin , J. F. , Pi , X. and Xie , L. ( 2019 ). Depletion of endothelial prolyl hydroxylase domain protein 2 and 3 promotes cardiomyocyte proliferation and prevents ventricular failure induced by myocardial infarction...

... proliferation. Here, we show that Wnt/β-catenin signalling potentiates neonatal mouse cardiomyocyte proliferation in vivo and immature human pluripotent stem cell-derived cardiomyocyte (hPSC-CM) proliferation in vitro . By contrast, Wnt/β-catenin signalling in adult mice is cardioprotective but fails to induce...

... strategies for regeneration interventions in humans. Grl Hey2 Heart regeneration Cardiomyocyte proliferation Lysine methyltransferase Zebrafish The human heart has limited capacity to regenerate new cardiac muscle after myocardial injury. Instead, impaired myocardium is replaced...

...Veronica Uribe; Radhan Ramadass; Deepika Dogra; S. Javad Rasouli; Felix Gunawan; Hiroyuki Nakajima; Ayano Chiba; Sven Reischauer; Naoki Mochizuki; Didier Y. R. Stainier ABSTRACT Cardiomyocyte proliferation is crucial for cardiac growth, patterning and regeneration; however, few studies have...

... and Neuregulin play essential roles in stimulating cardiomyocyte proliferation. These factors activate the Ras/MAPK pathway, which is tightly controlled by the feedback attenuator Dual specificity phosphatase 6 (Dusp6), an ERK phosphatase. Here, we show that suppressing Dusp6 function enhances cardiac...

... proliferation and hypertrophy during neonatal heart repair following cryoinjury and apex resection. Heart repair Heart regeneration Cardiomyocyte proliferation GATA4 FGF16 Myocardial infarction is becoming the leading cause of death worldwide. During myocardial infarction, a substantial number...

....116.304377 Huang , Y. , Harrison , M. R. , Osorio , A. , Kim , J. , Baugh , A. , Duan , C. , Sucov , H. M. and Lien , C.-L. ( 2013 ). Igf signaling is required for cardiomyocyte proliferation during zebrafish heart development and regeneration . PLoS ONE   8...

... proliferation through inhibition of adenylate cyclase. Conversely, high concentrations of natriuretic peptides reduce cardiomyocyte proliferation through activation of the particulate guanylate cyclase-linked natriuretic peptide receptors Npr1 and Npr2, and activation of protein kinase G. These data link...

... in mass to provide the oxygen delivery demands of embryonic growth. The developing heart must orchestrate regional differences in cardiomyocyte proliferation to control cardiac morphogenesis. During ventricular wall formation, the compact myocardium proliferates more vigorously than the trabecular...

...Peng Li; Susana Cavallero; Ying Gu; Tim H. P. Chen; Jennifer Hughes; A. Bassim Hassan; Jens C. Brüning; Mohammad Pashmforoush; Henry M. Sucov Secreted factors from the epicardium are believed to be important in directing heart ventricular cardiomyocyte proliferation and morphogenesis, although...

... factors such as Raldh2, dHAND, GATA4 and MLC2v, by either direct and/or indirect mechanisms through its effect on cardiomyocyte proliferation. To explore the mechanisms by which cell proliferation was affected in the transgenic hearts, semi-quantitative RT-PCR analysis of cell cycle regulators...