... and describe their transcriptional profiles. Mesp1 , a transiently expressed mesodermal transcription factor, is canonically described as an early regulator of cardiac specification. However, we observed perdurance of CPC transgene-expressing cells in Mesp1 mutants, albeit mislocalized, prompting us...

... in the cardiac regeneration response to injury. Cardiac neural crest cells Cardiac specification Myocardium Heart development Cardiac regeneration Neural crest cells (NCCs) are a multipotential population of cells unique to vertebrates that arise after delamination from the dorsal-most aspect...

...( Davidson and Levine, 2003 ). After metamorphosis, the Ciona heart rudiment differentiates into a contractile linear tube, which expresses orthologs of vertebrate heart structural genes including a cardiac-specific splice variant of Troponin I ( MacLean et al.,1997 ). Cardiac specification...