... that are differentiated from human pluripotent stem cells in vitro , discussing methods to drive cardiomyocyte maturation, as an example. hiPSC-derived cardiomyocytes Cardiac maturation Cardiac organoids Engineered heart tissue Cardiac microtissues Fig. 1. Features of immature and mature...

... different approaches and recent efforts to overcome these challenges in the field using a new generation of self-organizing embryonic and cardiac organoids. References Abu-Issa , R. and Kirby , M. L . ( 2007 ). Heart field: from mesoderm to heart tube . Annu. Rev. Cell Dev. Biol . 23...

... tissues ( Yang et al., 2014 ). Mechanical loading is used in these cultures as it improves sarcomere length, organization of contractile proteins and functionality ( Tulloch et al., 2011 ; Fink et al., 2000 ). 3D-engineered human cardiac organoids (hCOs) therefore provide a functional model with which...