... signalling centre from which Gbx2, in response to Tbx1, triggers essential directional cues to the adjacent cardiac neural crest cells (cNCCs)en route to the caudal PAAs. Abrogation of this signal generates cNCC patterning defects leading to PAA abnormalities. Finally, we showed that the Slit/Robo signalling...

...Shasha Liu; Fangyu Liu; Amanda E. Schneider; Tara St. Amand; Jonathan A. Epstein; David E. Gutstein Connexin 43 (Cx43) is expressed in the embryonic heart, cardiac neural crest (CNC) and neural tube, and germline knockout (KO) of Cx43 results in aberrant cardiac outflow tract (OFT) formation...

...Wood Yee Chan; Chui Shan Cheung; Kim Ming Yung; Andrew J. Copp A sub-population of the neural crest is known to play a crucial role in development of the cardiac outflow tract. Studies in avians have mapped the complete migratory pathways taken by `cardiac' neural crest cells en route from...

... mutants, suggesting a defect in cardiac neural crest development during outflow tract formation. In addition, ∼90%of Dvl2 -/- mice have vertebral and rib malformations that affect the proximal as well as the distal parts of the ribs. These skeletal abnormalities were more pronounced in mice deficient...

... of cranial neural crest migrate from the hindbrain into the outflow tract of the heart where they contribute to the septum that divides the pulmonary and aortic channels. In Splotch mutant mice, which lack a functional Pax3 gene, migration of cardiac neural crest is deficient and aorticopulmonary septation...

... into the proximal cardiac outflow tract. 31 5 2001 ©2001. 2001 Semaphorin 3C Mouse Cardiac neural crest Interrupted aortic arch Persistent truncus arteriosus PlexinA2 Chemoattractant Sema3C Classic studies performed almost 20 years ago demonstrated that perturbations of migrating...