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Keywords: Cardiac differentiation
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Journal Articles

LncRNA HBL1 is required for genome-wide PRC2 occupancy and function in cardiogenesis from human pluripotent stem cells

Open Access
Juli Liu, Sheng Liu, Lei Han, Yi Sheng, Yucheng Zhang, Il-Man Kim, Jun Wan, Lei Yang
Journal: Development
Development (2021) 148 (13): dev199628.
https://doi.org/10.1242/dev.199628
Published: 28 June 2021
... remains elusive. Here, we found that human-specific heart brake lncRNA 1 ( HBL1 ) interacted with two PRC2 subunits, JARID2 and EED, in human pluripotent stem cells (hPSCs). Loss of JARID2, EED or HBL1 significantly enhanced cardiac differentiation from hPSCs. HBL1 depletion disrupted genome-wide PRC2...
View articletitled, LncRNA HBL1 is required for genome-wide PRC2 occupancy and function in cardiogenesis from human pluripotent stem cells
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Includes: Supplementary data
Journal Articles

Wnt inhibition promotes vascular specification of embryonic cardiac progenitors

Open Access
David E. Reichman, Laura Park, Limor Man, David Redmond, Kenny Chao, Richard P. Harvey, Makoto M. Taketo, Zev Rosenwaks, Daylon James
Journal: Development
Development (2018) 145 (1): dev159905.
https://doi.org/10.1242/dev.159905
Published: 8 January 2018
... inhibitory Wnt signaling via Wnt5a fosters endothelial differentiation of Nkx2.5 + cardiac progenitor cells during mouse embryogenesis and human pluripotent stem cell differentiation. Cardiac development Cardiac differentiation Wound healing Myocardial infarction Myocardial scar formation...
View articletitled, Wnt inhibition promotes vascular specification of embryonic cardiac progenitors
Open the PDF for Wnt inhibition promotes vascular specification of embryonic cardiac progenitors in another window
Includes: Supplementary data