... during late stage regeneration fully suppresses overgrowth. Cell transplantations demonstrate longfin t2 -ectopic kcnh2a acts tissue autonomously within the fin intra-ray mesenchymal lineage. Temporal inhibition of the Ca 2+ -dependent phosphatase calcineurin indicates it likewise entirely acts late...

...Nissrine Daou; Sylvie Lecolle; Suzie Lefebvre; Bruno della Gaspera; Frédéric Charbonnier; Christophe Chanoine; Anne-Sophie Armand The calcineurin/NFAT (nuclear factor of activated T-cells) signaling pathway is involved in the modulation of the adult muscle fiber type, but its role...

..., the closest living invertebrate group to the vertebrates, we have identified a new signalling pathway for cell cycle resumption in which CaMKII plays no part. Instead, we find that the Ca 2+ -activated phosphatase calcineurin (CN) is required for egg activation. Moreover, we demonstrate that parthenogenetic...

.... Of the calcineurin,p38-MAPK, PI3K and CaMK pathways, only the calcineurin pathway was inhibited when Kir2.1-linked hyperpolarization was blocked. The CaMK pathway, although Ca 2+ dependent, is unaffected by changes in membrane potential or block of Kir2.1 channels. Concerning the p38-MAPK and PI3K pathways...

... of novel transgenic lines and fluorescent immunohistochemistry to analyze further the role of various genetic (Notch and Calcineurin signaling) and epigenetic (heart function)pathways in this process. In addition, from a large-scale forward genetic screen we identified 55 mutants, defining 48 different...