... driving their epithelial-to-mesenchymal transition. Neural crest EMT Morphogens Cadherins Transcription factors Post-translational modifications School of Veterinary Medicine, University of California, Davis http://dx.doi.org/10.13039/100009751 National Science Foundation...

... of organisation are largely unknown. We have previously shown that the assembly of motor neurons into nuclei depends on cadherin-mediated adhesion. Here, we demonstrate that the emergence of mature topography among motor nuclei involves a novel interplay between spontaneous activity, cadherin expression and gap...

... that absence of the cadherin regulator p120 catenin (p120ctn) from the renal mesenchyme prior to tubule formation leads to decreased cadherin levels with abnormal morphologies of early tubule structures and developing glomeruli. In addition, mutant mice develop cystic kidney disease, with markedly increased...

... maturation of epithelial rosettes in the pLLp. In addition, atoh1a inhibits e-cadherin expression, which is likely to reduce cohesion and contribute to fragmentation of the pLLp. Together, our observations reveal a genetic regulatory network that explains why atoh1a expression must be restricted by Notch...

...Lenka Libusova; Marc P. Stemmler; Andreas Hierholzer; Heinz Schwarz; Rolf Kemler We conditionally substituted E-cadherin (E-cad; cadherin 1) with N-cadherin (N-cad; cadherin 2) during intestine development by generating mice in which an Ncad cDNA was knocked into the Ecad locus. Mutant mice were...

...Sarah H. Barnes; Stephen R. Price; Corinna Wentzel; Sarah C. Guthrie Cadherin-7 (Cad7) and cadherin-6B (Cad6B) are expressed in early and late phases of cranial motoneuron development, respectively. Cad7 is expressed by cranial motoneurons soon after they are generated, as well...

... for the cell adhesion molecule N-cadherin and its interaction with Slit1-Robo2 during gangliogenesis in vivo. A common feature of chick trigeminal and epibranchial ganglia is the expression of N-cadherin and Robo2 on placodal neurons and Slit1 on neural crest cells. Interestingly, N-cadherin localizes...

... by signaling through G-protein-coupled receptors. In this paper, we show that the cortical actin network colocalizes with foci of cadherin expressed on the cell surface. We then show that cell-surface cadherin expression is both necessary and sufficient for cortical actin assembly and requires the associated...

... unknown. Here, we demonstrate that the Drosophila DE- and DN-cadherins have opposing effects on rotation. DE-cadherin promotes rotation, as DE-cad mutant ommatidia rotate less than wild type or not at all. By contrast, the two DN-cadherins act to restrict this movement, with ommatidia rotating too fast...

... on the Drosophila eye, we proposed that a crucial step in this process is the establishment of graded expression of the cadherin Dachsous (Ds) and the Golgi-associated protein Four-jointed (Fj). These gradients were proposed to specify the direction of polarization by producing an activity gradient of the cadherin...

... were assayed for function in vivo. We find that cleavage and secretion of Fj is not necessary for activity,and that Golgi-anchored Fj has increased activity over wild type. fj has similar phenotypes to those caused by mutations in the cadherin-encoding genes fat ( ft ) and dachsous ( ds ). We show...

...Takayoshi Inoue; Taro Tanaka; Masatoshi Takeichi; Osamu Chisaka; Shun Nakamura; Noriko Osumi ABSTRACT In ventricular cells of the mouse telencephalon, differential expression of cadherin cell adhesion molecules defines neighbouring regions; R-cadherin delineates the future cerebral cortex, while...

...Jonathan Pettitt; William B. Wood; Ronald H. A. Plasterk ABSTRACT Several genes that encode members of the cadherin super-family have been identified in Caenorhabditis elegans . Based on the roles of cadherins in vertebrates and Drosophila , it is expected that they function in the control...

...Shinichi Nakagawa; Masatoshi Takeichi ABSTRACT We identified two cadherins, c-cad6B and c-cad7, expressed by neural crest cells at their premigratory and migratory stages, respectively, in chicken embryos. cDNA transfection experiments showed that both were homophilic adhesion molecules, endowing...

...François Fagotto; Barry M. Gumbiner ABSTRACT β-catenin is a cytoplasmic protein associated with cadherin adhesion molecules and has been implicated in axis formation in Xenopus (McCrea, P. D., Brieher, W. M. and Gumbiner, B. M. (1993) J. Cell Biol . 127, 477-484). We have studied its distribution...

...Giovanni Levi; Dorit Ginsberg; Jeanne-Marie Girault; Ilana Sabanay; Jean Paul Thiery; Benjamin Geiger ABSTRACT EP-cadherin is a novel Xenopus Ca +2 -dependent adhesion molecule, which shares comparable homology with mouse E- and P-cadherins (Ginsberg, De Simone and Geiger; 1991, Development 111...

...Dorit Ginsberg; Douglas Desimone; Benjamin Geiger Two distinct cadherin cDNA clones of Xenopus laevis were isolated from a stage 17 embryo cDNA library. Analysis of the complete deduced amino acid sequences indicated that one of these molecules is closely homologous to chicken and mouse N-cadherin...

...Giovanni Levi; Barry Gumbiner; Jean Paul Thiery ABSTRACT A vast amount of experimental evidence suggests that cell surface molecules involved in cell-to-cell and/or cell-to-substrate interactions participate in the control of basic events in morphogenesis. E-cadherin is a cell adhesion molecule...

...Yohei Hirai; Akinao Nose; Shigeyasu Kobayashi; Masatoshi Takeichi ABSTRACT The role of Ca 2+ -dependent cell-cell adhesion mol ecules, E- and P-cadherins, in the histogenesis of mouse embryonic lung was studied. All epithelial cells of the lung express both E- and P-cadherin at the early...

...Yohei Hirai; Akinao Nose; Shigeyasu Kobayashi; Masatoshi Takeichi ABSTRACT Expression and the role of E- and P-cadherin in the histogenesis of the surface epidermis and hair follicles were examined using the upper lip skin of the mouse. P-cadherin is expressed exclusively in the proliferating...