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Keywords: Cadherin
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Journal Articles
Journal: Development
Development (2019) 146 (21): dev183269.
Published: 08 November 2019
...Karolina Punovuori; Rosa P. Migueles; Mattias Malaguti; Guillaume Blin; Kenneth G. Macleod; Neil O. Carragher; Tim Pieters; Frans van Roy; Marc P. Stemmler; Sally Lowell ABSTRACT A switch from E- to N-cadherin regulates the transition from pluripotency to neural identity, but the mechanism by which...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev174623.
Published: 11 October 2019
.... Cadherins, the major cell adhesion molecules, form adherens junctions connecting epithelial cells. Numerous studies of Bilateria have shown that cadherins are associated with the regulation of cell differentiation, cell shape changes, cell migration and tissue morphogenesis. To date, the role of cadherins...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (4): dev157495.
Published: 14 February 2018
... downstream of integrin and cadherin pathways. A regulatory toolbox of GEF and GAP proteins precisely coordinates Rho protein activities, yet defining the involvement of specific regulators within a cellular context remains a challenge due to overlapping and coupled activities. Here, we demonstrate that...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (2): dev157941.
Published: 26 January 2018
... cue for setting up the apical-basal polarity axis, is regulated by active Rap1 acting both through, and independently of, the Cno Rap1-binding domain. Cadherin Cell adhesion Morphogenesis Epithelia Polarity Canoe/Afadin, Drosophila Cell polarity – the ability to differentially...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (23): 4437–4449.
Published: 01 December 2017
... numerical model that incorporates attractive, as well as repulsive, forces was constructed to explain this diversity and robustness. Embryogenesis Diversity Robustness C. elegans Computer modeling Cadherin In multicellular organisms, nearby cells communicate with each other by sending...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (23): 4363–4376.
Published: 01 December 2017
.... Xenopus Adhesion Cadherin Fibronectin Gastrulation Keratin Coordinated cellular movements are a key feature of many morphogenetic processes that occur in metazoan development. The cell and tissue rearrangements responsible for these movements often play out within the confined spaces of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (4): 708–719.
Published: 15 February 2017
... subsequently promotes cell movement towards the equator. These data suggest that cell division is the major driving force for cell movement. In zebrafish, E-cadherin is expressed in lens epithelium, whereas N-cadherin is required for lens fiber growth. E-cadherin reduced lens epithelial cell movement, whereas...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (4): 664–676.
Published: 15 February 2017
... striking complementary pattern to N-cadherin (CDH2), marking the interface of the future somite boundary in the anterior PSM. Gain and loss of function of PAPC in chicken embryos disrupted somite segmentation by altering the CDH2-dependent epithelialization of PSM cells. Our data suggest that clathrin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (12): 2121–2134.
Published: 15 June 2016
...Isabel Martinez-Garay; Cristina Gil-Sanz; Santos J. Franco; Ana Espinosa; Zoltán Molnár; Ulrich Mueller Cadherins are crucial for the radial migration of excitatory projection neurons into the developing neocortical wall. However, the specific cadherins and the signaling pathways that regulate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (4): 715–727.
Published: 15 February 2016
... convergence force generation requires MII contractility and we identify a set of molecular phenotypes correlated with both this failure of convergence force generation in explants and of blastopore closure in whole embryos. These include reduced rates of actin movement, alterations in C-cadherin dynamics and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (24): 4784–4793.
Published: 15 December 2014
... expressed in a subset of cortical axons in the rat. We found that T-cadherin (T-cad), a member of the cadherin family, is expressed in deep-layer cell axons projecting to subcortical structures, but not in upper layer callosal axons projecting to the contralateral cortex. Ectopic expression of T-cad in...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (12): 2506–2515.
Published: 15 June 2014
...Matthew R. Clay; Mary C. Halloran The epithelial-to-mesenchymal transition (EMT) is a complex change in cell phenotype that is important for cell migration, morphogenesis and carcinoma metastasis. Loss of epithelial cell adhesion and tight regulation of cadherin adhesion proteins are crucial for...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (10): 1987–1998.
Published: 15 May 2014
... 2014 Actin Adhesion Apical Cadherin Constriction Myosin Epithelial tissues consist of cells that are polarized along their apical-basal axes and held together by cell-cell adhesion. At various times in the life of an organism, epithelial tissues undergo remodeling events, thereby...
Journal Articles
Journal: Development
Development (2014) 141 (8): 1671–1682.
Published: 15 April 2014
... The Company of Biologists Ltd 2014 Notch signaling Adherens junction Neurogenesis Neural stem/progenitor cell Apical endfoot Cadherin Mouse Chick During vertebrate development, specific progenitors in each organ primordium repeatedly undergo cell division with profound...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (8): 1774–1784.
Published: 15 April 2013
... recruit R-cadherin. Furthermore, we demonstrate that afadin is required for Par complex formation. Together, these results suggest that afadin acts upstream of the Par complex to regulate the integration and/or coalescence of membrane microdomains, thereby establishing apical-basal polarity and lumen...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (2): 255–265.
Published: 15 January 2013
... ) Competing interests statement The authors declare no competing financial interests. © 2013. Published by The Company of Biologists Ltd Niche Adhesion Cadherin Integrin Stem cell Various populations of adult stem cells reside in the body and undergo continuous self-renewal...
Journal Articles
Journal: Development
Development (2012) 139 (20): 3786–3794.
Published: 15 October 2012
..., including selective Vasa protein accumulation and transcriptional activation of nanos ; their descendants are passively displaced towards the animal pole by secondary mesenchyme cells and the elongating archenteron during gastrulation; Cadherin (G form) has an important role in their development and...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (14): 2547–2556.
Published: 15 July 2012
... the embryo. We show that PGCs enrich HMR-1/E-cadherin at their surfaces to stick to endoderm. HMR-1 expression in PGCs is necessary and sufficient to ensure internalization, suggesting that HMR-1 can promote PGC-endoderm adhesion through a mechanism other than homotypic trans interactions between the...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (10): 1754–1764.
Published: 15 May 2012
...Sarah J. Kurley; Brian Bierie; Robert H. Carnahan; Nichole A. Lobdell; Michael A. Davis; Ilse Hofmann; Harold L. Moses; William J. Muller; Albert B. Reynolds Although p120-catenin (p120) is crucial for E-cadherin function, ablation experiments in epithelial tissues from different organ systems...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (10): 1893–1902.
Published: 15 May 2011
... about how cell numbers are controlled in specific cell cohorts along the dorsoventral axis of the neural tube. Here, we show that FatJ cadherin, identified in a large-scale RNA interference (RNAi) screen of cadherin genes expressed in the neural tube, is localised to progenitors in intermediate regions...
Includes: Supplementary data