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Keywords: Cactus
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Journal: Development
Development (2017) 144 (23): 4450–4461.
Published: 1 December 2017
... in the blastoderm embryo. During this stage, Dorsal is sequestered outside the nucleus by the IκB homolog Cactus. Toll signaling on the ventral side breaks the Dorsal/Cactus complex, allowing Dorsal to enter the nucleus to regulate target genes. Fluorescent data show that Dorsal accumulates on the ventral side...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2001) 128 (15): 2963–2974.
Published: 1 August 2001
.... Nuclear uptake of Dorsal, a Rel/NFκB homolog, is controlled by the interaction with its cognate IκB inhibitor protein Cactus, which is degraded on the ventral side of the embryo in response to dorsal group signaling. Previous studies have suggested that an N-terminally located kinase target motif similar...
Journal Articles
Journal: Development
Development (1998) 125 (11): 2159–2169.
Published: 1 June 1998
... demonstration that maternally expressed Dif is regulated by Cactus and the dorsal group is consistent with the idea that Dif is regulated by this pathway in the immune system. Our finding also lends in vivo support to the observation that Dif and Cactus interact physically in vitro ( Tatei and Levine, 1995...
Journal Articles
Journal: Development
Development (1997) 124 (19): 3855–3864.
Published: 1 October 1997
...David N. Edwards; Par Towb; Steven A. Wasserman ABSTRACT A signaling pathway active on the ventral side of the Drosophila embryo defines dorsoventral polarity. A cell surface signal relayed by Toll, Tube and Pelle releases the Rel-related protein Dorsal from its cytoplasmic inhibitor Cactus; free...
Journal Articles
Journal: Development
Development (1993) 117 (1): 135–148.
Published: 1 January 1993
... expression of zygotic genes along the dorsoventral axis. The dorsal protein is cytoplasmic in early embryos, possibly because of a direct interaction with cactus. In response to a ventral signal, dorsal protein becomes partitioned into nuclei of cleavagestage syncytial blastoderms such that the ventral...
Journal Articles