...). The nuclear architectural proteins cohesin and CCCTC-binding factor (CTCF) contribute to chromatin structure and gene regulation. We show here that normal cohesin function is important for ZGA in zebrafish. Depletion of the cohesin subunit Rad21 delays ZGA without affecting cell cycle progression. In contrast...

... nervous system and how such diversity may be used in neural circuit assembly. CTCF Cohesin Promoter choice Single cell diversity Homophilic interaction Self-avoidance Protocadherins (Pcdhs), which are predominantly expressed in the nervous system, constitute the largest...

... with the Fab-7 insulator, which contains seven GAF (Trl – FlyBase) binding sites required for enhancer blocking ( Schweinsberg et al., 2004 ), and with the Mcp insulator, which contains a binding site for the CTCF insulator protein ( Holohan et al., 2007 ). These insulators failed to support yellow...

...Le-Ben Wan; Hua Pan; Sridhar Hannenhalli; Yong Cheng; Jun Ma; Andrew Fedoriw; Victor Lobanenkov; Keith E. Latham; Richard M. Schultz; Marisa S. Bartolomei CTCF is a multifunctional nuclear factor involved in epigenetic regulation. Despite recent advances that include the systematic discovery...