..., a common finding in transgenic experiments ( Milot et al., 1996 ; Kioussis and Festenstein, 1997 ). An important question is at what cellular stage does CNS patterning arise in development ( Panchision et al., 1998 ; Edlund and Jessell, 1999 ). Is patterning already established in stem cells...

... (e-mail: [email protected] ) 13 06 1997 © 1997 by Company of Biologists 1997 Drosophila msh homeobox neurogenesis CNS patterning Both in vertebrates and in invertebrates such as Drosophila , the central nervous system (CNS) arises from a two-dimensional structure...

... Institute of Biomolecular Medicine, 540 First Avenue, New York, NY 10016, USA 30 05 1996 © 1996 by Company of Biologists 1996 sonic hedgehog cAMP-dependent protein kinase A CNS patterning transgenic mouse The notochord has been known for some time to act as the source...

... ). * Author for correspondence † Present address: Center for Molecular and Developmental Biology, Kyoto University, Kitashirakawa, Sakyo-Ku, Kyoto 606-01, Japan 13 09 1994 © 1995 by Company of Biologists 1995 Shh peptides CNS patterning limb patterning chick mouse...