..., mechanistic insights. An attractive system for the systematic study of neuronal development is provided by Drosophila CNS midline cells ( Fig. 1 ) ( Wheeler et al., 2006 ). These cells reside between the two hemiganglia of the Drosophila ventral nerve cord (VNC). Initially consisting of 16 ectodermal...

...Joseph D. Watson; Scott R. Wheeler; Stephanie B. Stagg; Stephen T. Crews The Drosophila CNS contains a variety of glia, including highly specialized glia that reside at the CNS midline and functionally resemble the midline floor plate glia of the vertebrate spinal cord. Both insect and vertebrate...

...Scott R. Wheeler; Stephanie B. Stagg; Stephen T. Crews The study of how transcriptional control and cell signaling influence neurons and glia to acquire their differentiated properties is fundamental to understanding CNS development and function. The Drosophila CNS midline cells are an excellent...

... at the Drosophila embryonic CNS midline. We detect genetic and/or physical interactions between Fra and these effector molecules that suggest that they act in concert to guide axons across the midline. Mutations in Abl and trio dominantly enhance fra and Netrin mutant CNS phenotypes, and fra;Abl and fra;trio double...

...Yalda Sedaghat; Wilson F. Miranda; Margaret J. Sonnenfeld We establish that the jing zinc-finger transcription factor plays an essential role in controlling CNS midline and tracheal cell differentiation. jing transcripts and protein accumulate from stage 9 in the CNS midline, trachea...

...% reduction in the number of cortical CNS cells. A similar thinning of the ventral nerve cord can be observed following mechanical ablation of the midline cells. We have identified a number of specific neuronal and glial cell markers that are reduced in CNS midline-less embryos (in single-minded embryos...

...Karin Lüer; Joachim Urban; Christian Klämbt; Gerhard M. Technau ABSTRACT The Drosophila ventral midline cells generate a discrete set of CNS lineages, required for proper patterning of the ventral ectoderm. Here we provide the first evidence that the CNS midline cells also exert inductive effects...

... that this element is required for CNS midline transcription for all three genes. Multimerization of a 20 bp DNA fragment containing the ACGTG sequence is sufficient for MLP transcription. These experiments further reinforce the functional similarity between control of CNS midline transcription and aromatic...

.... * Author for all correspondence 22 03 1990 14 05 1990 © 1990 by Company of Biologists 1990 Drosophila embryonic development tyrosine kinase receptors faint little ball CNS midline muscle attachments The faint little ball (flb) locus was first recognized...