... of structure and function ( Joven and Simon, 2018 ; Lust and Tanaka, 2019 ). Damage to the central nervous system (CNS) usually affects both neuronal and non-neuronal cell types and, depending on the extent of damage, may lead to behavioural abnormalities. In order to restore function, both missing cells...

... to the poor regenerative capabilities of the central nervous system (CNS). Here, we show that adult peripheral nerve is a more quiescent tissue than the CNS, yet all cell types within a peripheral nerve proliferate efficiently following injury. Moreover, whereas oligodendrocytes are produced throughout life...

...Murielle Saade; Jose Blanco-Ameijeiras; Elena Gonzalez-Gobartt; Elisa Martí ABSTRACT Embryonic development of the central nervous system (CNS) requires the proliferation of neural progenitor cells to be tightly regulated, allowing the formation of an organ with the right size and shape...

... genes and enhancers. Analysis of Drosophila CNS midline cell development provides a useful system for studying transcriptional regulation at the genomic level due to a large, well-characterized set of midline-expressed genes and in vivo validated enhancers. In this study, FAIRE-seq on FACS-purified...

...Olivier Urwyler; Azadeh Izadifar; Dan Dascenco; Milan Petrovic; Haihuai He; Derya Ayaz; Anna Kremer; Saskia Lippens; Pieter Baatsen; Christopher J. Guérin; Dietmar Schmucker Determining direct synaptic connections of specific neurons in the central nervous system (CNS) is a major technical...

... ) Competing interests The authors declare no competing financial interests. 21 12 2013 1 9 2014 © 2014. Published by The Company of Biologists Ltd 2014 Angiogenesis Brain CNS Hemorrhage Sprouting Integrin αVβ8 TGFβ Mouse In angiogenesis, new blood vessels form from...

... by The Company of Biologists Ltd 2013 Drosophila CNS Hox genes Leucokinin One of the main aims of developmental neuroscience is to understand the mechanisms underlying the spatiotemporal specification of distinct classes of neurons. These are the responsibility of pattern genes...

...Ruifen Weng; Stephen M. Cohen MicroRNAs (miRNAs) have been implicated as regulators of central nervous system (CNS) development and function. miR-124 is an evolutionarily ancient, CNS-specific miRNA. On the basis of the evolutionary conservation of its expression in the CNS, miR-124 is expected...

...Volker Kroehne; Dorian Freudenreich; Stefan Hans; Jan Kaslin; Michael Brand Severe traumatic injury to the adult mammalian CNS leads to life-long loss of function. By contrast, several non-mammalian vertebrate species, including adult zebrafish, have a remarkable ability to regenerate injured...

...-epithelial tissues. * Author for correspondence ( acarmena@umh.es ) Competing interests statement The authors declare no competing financial interests. 24 1 2011 © 2011. 2011 Neuron-glia interactions Canoe/AF-6 Drosophila CNS Wrapper DE-cadherin Nrx-IV Midline...

... of Notch across progenitor domain boundaries. * Authors for correspondence ( urban.lendahl@ki.se ; jonas.muhr@licr.ki.se ; johan.ericson@ki.se ) Competing interests statement The authors declare no competing financial interests. 27 11 2009 © 2010. 2010 CNS Homeodomain...

... expression of dbx relative to that of eve and hb9 in sibling neurons is crucial for proper neuronal specification, as misexpression of dbx in motoneurons dramatically hinders motor axon outgrowth. 24 7 2009 © 2009. © 2009. 2009 dbx Neuronal specification Drosophila eve hb9 CNS...

...Ina Strate; Tan H. Min; Dobromir Iliev; Edgar M. Pera Retinoic acid (RA) is an important morphogen that regulates many biological processes, including the development of the central nervous system (CNS). Its synthesis from vitamin A (retinol) occurs in two steps, with the second reaction...

... executes this role by counteracting the function of Antp in promoting cell survival. Thus, two Hox genes contribute to segment patterning and diversity in the embryonic CNS by carrying out opposing roles in the survival of specific differentiated motoneurons. We were not able to analyze NB2-4t...

... CNS. We identified two partners of Nab: the zinc-finger transcription factors Rotund and Squeeze. Nab is co-expressed with squeeze in a subset of neurons in the embryonic ventral nerve cord and with rotund in a circular domain of the distal-most area of the wing disc. Our results indicate that Nab...

... in the Drosophila embryo. Here,we provide biochemical and genetic evidence that Shot functions with a novel translation inhibitor, Krasavietz (Kra, Exba), to steer longitudinally directed CNS axons away from the midline. Kra binds directly to the C-terminus of Shot, and this interaction is required for the activity...

...Ana Rogulja-Ortmann; Karin Lüer; Janina Seibert; Christof Rickert; Gerhard M. Technau Although programmed cell death (PCD) plays a crucial role throughout Drosophila CNS development, its pattern and incidence remain largely uninvestigated. We provide here a detailed analysis of the occurrence...

.... * Authors for correspondence (e-mail: urbach@uni-mainz.de ; technau@unimainz.de ) 31 8 2006 © 2006. 2006 CNS Brain Neuroectoderm Neuroblasts Dorsoventral patterning Cell fate vnd msh ind Glia Drosophila The Drosophila central nervous system, which can...

...Mami Matsuo-Takasaki; Michiru Matsumura; Yoshiki Sasai During gastrulation in Xenopus , the head ectoderm is subdivided into the central nervous system (CNS) anlage (neural plate) and the non-CNS ectoderm (i.e. epidermis, placodes and neural crest). The winged-helix transcription factor Xfoxi1a...

... during establishment and maintenance of the anterior CNS. Fgf8 knockout studies in mice and zebrafish showed that Fgf8 is essential to maintain the MHB, to induce the cerebellum and to pattern the midbrain( Crossley et al., 1996 ; Brand et al., 1996 ; Reifers et al., 1998 ; Picker et al., 1999...