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Keywords: CDON
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Journal Articles
Journal: Development
Development (2021) 148 (19): dev199585.
Published: 05 October 2021
...-tetrahydrocannabinol (THC) induces two hallmark HH loss-of-function phenotypes (HPE and ventral neural tube patterning defects) in Cdon mutant mice, which have a subthreshold deficit in HH signaling. THC therefore acts as a ‘conditional teratogen’, dependent on a complementary but insufficient genetic insult. In vitro...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (23): dev189076.
Published: 14 December 2020
...Martha L. Echevarría-Andino; Benjamin L. Allen ABSTRACT The Hedgehog (HH) pathway controls multiple aspects of craniofacial development. HH ligands signal through the canonical receptor PTCH1, and three co-receptors: GAS1, CDON and BOC. Together, these co-receptors are required during embryogenesis...
Includes: Supplementary data