... of Biologists Ltd 2014 Germ line PGC CNOT6 CCR4 Nanos Pumilio Transcriptomics Sea urchin Author contributions G.M.W. and S.Z.S. conceived the project; S.Z.S., J.P.C. and A.H. developed FACS methods; S.Z.S. and N.O. performed experiments. A.M.R. performed bioinformatics analyses; T.R...

.... Regulation of Cyclin B and hunchback differ in two significant respects. First,Pumilio is dispensable for repression of Cyclin B (but not hunchback ) if Nanos is tethered via an exogenous RNA-binding domain. Nanos probably acts, at least in part, by recruiting the CCR4-Pop2-NOT deadenylase complex...

... turnover or translation remain largely unclear. Here, we report the identification of twin , a homolog of the yeast CCR4 deadenylase. We show that twin is important for the number and synchrony of cyst divisions and oocyte fate. Consistent with the deadenylase activity of CCR4 in yeast, our data suggest...