... build a new apical extracellular matrix (aECM) beneath a previously built aECM that is subsequently shed. The nuclear hormone receptor NHR-23 (also known as NR1F1) is an important regulator of C. elegans molting. NHR-23 expression oscillates in the epidermal epithelium, and soma-specific NHR-23...

... by controlling the completion of cytokinesis. Centralspindlin complex Cytokinesis Spermatheca Morphogenesis C . elegans Science and Technology Development Fund http://dx.doi.org/10.13039/501100006469 Fundo para o Desenvolvimento das Ciências e da Tecnologia http://dx.doi.org...

... of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/4.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Summary: In C. elegans , erm-1 mRNA localization to plasma membranes requires...

..., but surprisingly P granules are not essential for germ cell fate specification. Here, we describe a second condensate in the C. elegans germ plasm. Like canonical P-bodies found in somatic cells, ‘germline P-bodies’ contain regulators of mRNA decapping and deadenylation and, in addition, the intrinsically...

... to an EGF patterning signal. C. elegans EGFR ERK Ras Dauer Vulva National Institute of General Medical Sciences http://dx.doi.org/10.13039/100000057 R35GM131746 T32GM008798 F31GM126741 Caenorhabditis elegans larvae display remarkable developmental plasticity...

...-1 M domain during C. elegans embryonic morphogenesis. SrGAP α-Catenin Cadherin complex C. elegans Morphogenesis Cell-cell adhesion National Institute of General Medical Sciences http://dx.doi.org/10.13039/100000057 R01GM058038 R35GM145312 R01GM127687 Howard...

... a particular challenge in wavelengths occupied by commonly used fluorescent proteins (GFP, mNeonGreen). Stimulated by our work in C. elegans , we describe and validate Spectral Autofluorescence Image Correction By Regression (SAIBR), a simple platform-independent protocol and FIJI plug-in to correct...

... to specify endoderm and to control cleavage orientation in early C. elegans embryos . Dev. Cell 3 , 113 - 125 . 10.1016/S1534-5807(02)00185-5 Boeck , M. E. , Boyle , T. , Bao , Z. , Murray , J. , Mericle , B. and Waterston , R. ( 2011 ). Specific roles for the GATA...

... differentiation are known. Here, we show that the C. elegans Forkhead transcription factor UNC-130 is required in only one of three convergent lineages that produce the same glial cell type. UNC-130 acts transiently as a repressor in progenitors and newly-born terminal cells to allow the proper specification...

... 2021. Published by The Company of Biologists Ltd 2021 Summary: A multicolor transgene, NeuroPAL, is used to differentially label all male-specific neurons of C. elegans , thereby providing landmarks for gene expression, neuronal activity and cell fate analysis. C. elegans Nervous...

... of Caenorhabditis elegans development across multiple larval stages at high-resolution and with minimal effect on physiological development. Microfluidics Imaging Long-term C. elegans Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung http://dx.doi.org/10.13039...

... or radially symmetric class members display such lineage convergence. We show here that the C. elegans Atonal homolog lin-32 is differentially expressed in neuronal lineages that give rise to left/right or radially symmetric class members. Loss of lin-32 results in the selective loss of the expression of pan...

... following starvation at hatching. The mean position is displaced upon a temperature shift. Finally, highly significant variation was found among C. elegans wild isolates. Overall, this study reveals that the final position of these neurons is quite robust to stochastic variation, shows some sensitivity...

..., in regulating C. elegans molting, we discovered that NHR-23/NR1F1 is also constitutively expressed in developing primary spermatocytes and is a critical regulator of spermatogenesis. In this novel role, NHR-23/NR1F1 functions downstream of the canonical sex-determination pathway. Degron-mediated depletion...

... decisions during cell fate specification via consensus LAG-1/CSL binding sites within a conserved high occupancy target sequence. Autoregulation Notch C. elegans lag-1 CSL HOT Enhancer The intracellular domain of LIN-12/Notch is essentially a membrane-tethered transcriptional...

... components of the H3K4 regulatory machinery mutated in neurodevelopmental disorders and the process of axon guidance in C. elegans . Thus, our study supports an epigenetic-based model for the aetiology of neurodevelopmental disorders, based on an aberrant axon guidance process originating from deregulated...

...-avoidance by regulating cytoskeletal assembly in the dendrite. Actin C. elegans Dendrite Flamingo Planar polarity Self-avoidance Dendrite self-avoidance prevents crossover between sister dendrites from the same neuron, maximizing coverage of the sensory territory of individual dendrites...

... Competing interests The authors declare no competing or financial interests. 7 3 2020 6 6 2020 © 2020. Published by The Company of Biologists Ltd 2020 http://www.biologists.com/user-licence-1-1/ Summary: Transcript levels of the C. elegans asp-1 gene are controlled...

... with regulatory control in animal germ cells). In C. elegans , germ granules are specifically called P granules in the early embryo ( Fig. 3 A) ( Seydoux, 2018 ; Marnik and Updike, 2019 ) and they segregate to the P lineage with each successive cell division. Dual mechanisms of preferential coalescence...

...Louisa Mereu; Matthias K. Morf; Silvan Spiri; Peter Gutierrez; Juan M. Escobar-Restrepo; Michael Daube; Michael Walser; Alex Hajnal ABSTRACT The anchor cell (AC) in C. elegans secretes an epidermal growth factor (EGF) homolog that induces adjacent vulval precursor cells (VPCs) to differentiate...