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Keywords: C. elegans
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Journal Articles
Journal: Development
Development (2021) 148 (19): dev199493.
Published: 28 September 2021
... differentiation are known. Here, we show that the C. elegans Forkhead transcription factor UNC-130 is required in only one of three convergent lineages that produce the same glial cell type. UNC-130 acts transiently as a repressor in progenitors and newly-born terminal cells to allow the proper specification...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (18): dev199687.
Published: 16 September 2021
...). This contrasts the complete stereotypy and deterministic nature of all other C. elegans cell lineages, both neuronal and non-neuronal ( Sulston et al., 1980 ; Sulston and Horvitz, 1977 ). Moreover, this variability was reported to be restricted to the EF and DX neurons that descend from the U neuroblast...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (18): dev199674.
Published: 21 July 2021
... simple to fabricate, agar pad immobilization is invasive and results in a slowdown or complete arrest of development, precluding long-term observation ( Fang-Yen et al., 2012 ; Wolke et al., 2007 ). In recent years, a number of microfluidic approaches for C. elegans imaging have been reported...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (11): dev199224.
Published: 8 June 2021
... or radially symmetric class members display such lineage convergence. We show here that the C. elegans Atonal homolog lin-32 is differentially expressed in neuronal lineages that give rise to left/right or radially symmetric class members. Loss of lin-32 results in the selective loss of the expression of pan...
Includes: Supplementary data
Journal Articles
Journal: Development
Series: REVIEW COMMONS TRANSFER
Development (2021) 148 (5): dev196949.
Published: 5 March 2021
... following starvation at hatching. The mean position is displaced upon a temperature shift. Finally, highly significant variation was found among C. elegans wild isolates. Overall, this study reveals that the final position of these neurons is quite robust to stochastic variation, shows some sensitivity...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (22): dev193862.
Published: 27 November 2020
..., in regulating C. elegans molting, we discovered that NHR-23/NR1F1 is also constitutively expressed in developing primary spermatocytes and is a critical regulator of spermatogenesis. In this novel role, NHR-23/NR1F1 functions downstream of the canonical sex-determination pathway. Degron-mediated depletion...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (18): dev193482.
Published: 28 September 2020
... decisions during cell fate specification via consensus LAG-1/CSL binding sites within a conserved high occupancy target sequence. Autoregulation Notch C. elegans lag-1 CSL HOT Enhancer The intracellular domain of LIN-12/Notch is essentially a membrane-tethered transcriptional...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (15): dev190637.
Published: 7 August 2020
... components of the H3K4 regulatory machinery mutated in neurodevelopmental disorders and the process of axon guidance in C. elegans . Thus, our study supports an epigenetic-based model for the aetiology of neurodevelopmental disorders, based on an aberrant axon guidance process originating from deregulated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (14): dev179168.
Published: 31 July 2020
...-avoidance by regulating cytoskeletal assembly in the dendrite. Actin C. elegans Dendrite Flamingo Planar polarity Self-avoidance Dendrite self-avoidance prevents crossover between sister dendrites from the same neuron, maximizing coverage of the sensory territory of individual dendrites...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (14): dev190330.
Published: 24 July 2020
... activity . J. Mol. Biol.   422 , 18 - 32 . 10.1016/j.jmb.2012.06.005 Boulin , T. , Etchberger , J. F. and Hobert , O. ( 2006 ). Reporter gene fusions. WormBook. 1-23. (ed. The C. elegans Research Community): http://www.wormbook.org .   10.1895/wormbook.1.106.1 Carey , M...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (13): dev186817.
Published: 8 July 2020
... feature of cell biology. C. elegans strains were maintained using standard procedures ( Brenner, 1974 ). Worms were grown at 20°C and reared on nematode growth medium (NGM: 3 g/l NaCl; 17 g/l agar; 2.5 g/l peptone; 5 mg/l cholesterol; 1 mM CaCl 2 ; 1 mM MgSO 4 ; 2.7 g/l KH 2 PO 4 ; 0.89 g/l K...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (11): dev175760.
Published: 4 June 2020
...Louisa Mereu; Matthias K. Morf; Silvan Spiri; Peter Gutierrez; Juan M. Escobar-Restrepo; Michael Daube; Michael Walser; Alex Hajnal ABSTRACT The anchor cell (AC) in C. elegans secretes an epidermal growth factor (EGF) homolog that induces adjacent vulval precursor cells (VPCs) to differentiate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (7): dev183186.
Published: 6 April 2020
... ligands in this process remains poorly characterized. Here, we used the terminal divisions of the embryonic neuronal progenitors in C. elegans to characterize the role of Wnt ligands during this process, focusing on a lineage that produces the cholinergic interneuron AIY. We observed that, during...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (4): dev180448.
Published: 17 February 2020
...Elizabeth R. Cebul; Ian G. McLachlan; Maxwell G. Heiman ABSTRACT Dendrites develop elaborate morphologies in concert with surrounding glia, but the molecules that coordinate dendrite and glial morphogenesis are mostly unknown. C. elegans offers a powerful model for identifying such factors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (24): dev183780.
Published: 13 December 2019
... available for focal adhesions and adherens junctions, much less is known about mechanotransduction at hemidesmosomes. Here, we focus on the C. elegans plectin homolog VAB-10A, the only evolutionary conserved hemidesmosome component. In C. elegans , muscle contractions induce a mechanotransduction pathway...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (22): dev182873.
Published: 19 November 2019
.... , Oliver , D. , Lambert , C. M. and Francis , M. M. ( 2017 ). Excitatory neurons sculpt GABAergic neuronal connectivity in the C. elegans motor circuit . Development   144 , 1807 - 1819 . 10.1242/dev.141911 Bargmann , C. I. and Marder , E. ( 2013 ). From the connectome...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (22): dev180034.
Published: 18 November 2019
... to proliferative cell division, the C. elegans RNT-1/BRO-1 transcriptional repressor opposes POP-1 TCF expression in seam stem cells, which turns POP-1-induced differentiation into self-renewal. C. elegans Wnt signaling Runx Asymmetric cell division Stem cell division mode Transcriptional regulation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (21): dev179150.
Published: 12 November 2019
... of its motor activity remains unclear. Here, we examine cytokinesis in C. elegans embryos expressing non-muscle myosin motor mutants generated by genome editing. Two non-muscle motor-dead myosins capable of binding F-actin do not support cytokinesis in the one-cell embryo, and two partially motor...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev177378.
Published: 21 June 2019
...-licence-1-1/ Highlighted Article: Mutation of an autoregulatory motif of che-1 , a cell identity-specifying transcription factor, shows that autoregulation is required for both acquisition and maintenance of cellular identity in C. elegans . C. elegans Autoregulation Neuronal...
Journal Articles
Journal: Development
Development (2019) 146 (11): dev174508.
Published: 5 June 2019
... inclusions. Thus, we describe a new function for V0-ATPase in apical trafficking and epithelial polarity maintenance and the promising use of the C. elegans intestine as an in vivo model to better understand the molecular mechanisms of rare genetic enteropathies. * Author for correspondence ( gmichaux...
Includes: Supplementary data