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Keywords: C. elegans
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Journal Articles
Journal: Development
Development (2021) 148 (5): dev196949.
Published: 05 March 2021
... increased following starvation at hatching. The mean position is displaced upon a temperature shift. Finally, highly significant variation was found among C. elegans wild isolates. Overall, this study reveals that the final position of these neurons is quite robust to stochastic variation, shows some...
Includes: Supplementary data
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Reproductive biology
Journal: Development
Development (2020) 147 (22): dev193862.
Published: 27 November 2020
..., in regulating C. elegans molting, we discovered that NHR-23/NR1F1 is also constitutively expressed in developing primary spermatocytes and is a critical regulator of spermatogenesis. In this novel role, NHR-23/NR1F1 functions downstream of the canonical sex-determination pathway. Degron-mediated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (18): dev193482.
Published: 28 September 2020
... was significantly ( P <0.01) enriched in all available ChIP-seq tracks in C. elegans at the time we began this study, and therefore may be considered a ‘HOT region’ ( Wreczycka et al., 2019 ). Second, Chen et al. showed that LAG-1 also binds to this HOT region, strengthening our inference based...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (15): dev190637.
Published: 07 August 2020
... components of the H3K4 regulatory machinery mutated in neurodevelopmental disorders and the process of axon guidance in C. elegans . Thus, our study supports an epigenetic-based model for the aetiology of neurodevelopmental disorders, based on an aberrant axon guidance process originating from deregulated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (14): dev179168.
Published: 31 July 2020
...-avoidance by regulating cytoskeletal assembly in the dendrite. Actin C. elegans Dendrite Flamingo Planar polarity Self-avoidance Dendrite self-avoidance prevents crossover between sister dendrites from the same neuron, maximizing coverage of the sensory territory of individual dendrites...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (14): dev190330.
Published: 24 July 2020
... Competing interests The authors declare no competing or financial interests. 7 3 2020 6 6 2020 © 2020. Published by The Company of Biologists Ltd 2020 http://www.biologists.com/user-licence-1-1/ Summary: Transcript levels of the C. elegans asp-1 gene are controlled by...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (13): dev186817.
Published: 08 July 2020
... with regulatory control in animal germ cells). In C. elegans , germ granules are specifically called P granules in the early embryo ( Fig. 3 A) ( Seydoux, 2018 ; Marnik and Updike, 2019 ) and they segregate to the P lineage with each successive cell division. Dual mechanisms of preferential...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (11): dev175760.
Published: 04 June 2020
...Louisa Mereu; Matthias K. Morf; Silvan Spiri; Peter Gutierrez; Juan M. Escobar-Restrepo; Michael Daube; Michael Walser; Alex Hajnal ABSTRACT The anchor cell (AC) in C. elegans secretes an epidermal growth factor (EGF) homolog that induces adjacent vulval precursor cells (VPCs) to differentiate. The...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (7): dev183186.
Published: 06 April 2020
... ligands in this process remains poorly characterized. Here, we used the terminal divisions of the embryonic neuronal progenitors in C. elegans to characterize the role of Wnt ligands during this process, focusing on a lineage that produces the cholinergic interneuron AIY. We observed that, during...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (4): dev180448.
Published: 17 February 2020
...Elizabeth R. Cebul; Ian G. McLachlan; Maxwell G. Heiman ABSTRACT Dendrites develop elaborate morphologies in concert with surrounding glia, but the molecules that coordinate dendrite and glial morphogenesis are mostly unknown. C. elegans offers a powerful model for identifying such factors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (24): dev183780.
Published: 13 December 2019
... available for focal adhesions and adherens junctions, much less is known about mechanotransduction at hemidesmosomes. Here, we focus on the C. elegans plectin homolog VAB-10A, the only evolutionary conserved hemidesmosome component. In C. elegans , muscle contractions induce a mechanotransduction pathway in...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (22): dev182873.
Published: 19 November 2019
...: Insulin signaling is involved in C. elegans nervous system development as part of a mechanism that integrates intrinsic and activity-dependent gene expression programs. C. elegans Sensory neuron Nervous system development Insulin signaling The nervous system comprises a multitude of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (22): dev180034.
Published: 18 November 2019
... reproduction in any medium provided that the original work is properly attributed. We studied the stem cell-like precursors of the C. elegans epidermis to reveal the mechanisms that determine whether cells undergo symmetric or asymmetric cell divisions. The seam cells reside in two lateral epithelia...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (21): dev179150.
Published: 12 November 2019
... of its motor activity remains unclear. Here, we examine cytokinesis in C. elegans embryos expressing non-muscle myosin motor mutants generated by genome editing. Two non-muscle motor-dead myosins capable of binding F-actin do not support cytokinesis in the one-cell embryo, and two partially motor...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev177378.
Published: 21 June 2019
... Biologists Ltd 2019 http://www.biologists.com/user-licence-1-1/ Highlighted Article: Mutation of an autoregulatory motif of che-1 , a cell identity-specifying transcription factor, shows that autoregulation is required for both acquisition and maintenance of cellular identity in C. elegans...
Journal Articles
Journal: Development
Development (2019) 146 (11): dev174508.
Published: 05 June 2019
... inclusions. Thus, we describe a new function for V0-ATPase in apical trafficking and epithelial polarity maintenance and the promising use of the C. elegans intestine as an in vivo model to better understand the molecular mechanisms of rare genetic enteropathies. * Author for correspondence ( gmichaux...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (8): dev168153.
Published: 15 April 2019
...Julia P. Brandt; Mary Rossillo; Zhuo Du; David Ichikawa; Kristopher Barnes; Allison Chen; Marcus Noyes; Zhirong Bao; Niels Ringstad ABSTRACT The sensory nervous system of C. elegans comprises cells with varied molecular and functional characteristics, and is, therefore, a powerful model for...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (7): dev174029.
Published: 11 April 2019
... function in elongation. Three additional genes exhibited specific elongation defects ( ceh-43 , pha-1 and let-381 ). We will discuss ceh-43 and let-381 here (for a discussion of pha-1 see Fig. S6 ). CEH-43 is the sole C. elegans ortholog of the Distalless/Dlx homeobox genes that are involved...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (4): dev171124.
Published: 20 February 2019
... such neurons, we examined the C. elegans amphid, in which dendrites protrude through a glial channel at the nose. During development, amphid dendrites extend by attaching to the nose via DYF-7, a type of protein typically found in epithelial apical ECM. Here, we show that amphid neurons and glia...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (24): dev168666.
Published: 17 December 2018
...-licence-1-1/ Summary: The C. elegans cell polarity protein VANG-1 tempers Wnt-mediated neuronal migration by recycling Frizzled receptors from the neuronal membrane. C. elegans Wnt signaling Planar polarity Neuronal migration Endocytosis Frizzled Wiring of the nervous...
Includes: Supplementary data