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Keywords: C. elegans
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Journal Articles
Journal: Development
Development (2024) 151 (3): dev202146.
Published: 12 February 2024
... gene, a powerful regulator of aging. The homologous mutation in the human insulin receptor causes Donohue syndrome, establishing these mutant worms as an invertebrate model of this disease. Captopril functions in C. elegans by inhibiting ACN-1, the worm homolog of ACE. Reducing the activity of acn-1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2024) 151 (3): dev200981.
Published: 5 February 2024
... cleavages that are regulated by key proneural transcription factors. Asymmetric division Neuronal specification Proneural C . elegans Wellcome Trust http://dx.doi.org/10.13039/100010269 207483/Z/17/Z 105380/Z/14/Z Biotechnology and Biological Sciences Research Council...
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Reproductive biology
Journal: Development
Development (2023) 150 (21): dev201755.
Published: 17 October 2023
... are required for fertility in C. elegans and contribute to repression of X-linked genes in the germline. HDAC SIN3 X chromosome C. elegans Germline Proteomics Agence Nationale de la Recherche http://dx.doi.org/10.13039/501100001665 19-CE12-0025-01 Centre National de la...
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Neural development
Journal: Development
Development (2023) 150 (18): dev201654.
Published: 27 September 2023
.... , Quadroni , M. and Jin , Y. ( 2007 ). C. elegans RPM-1 regulates axon termination and synaptogenesis through the Rab GEF GLO-4 and the Rab GTPase GLO-1 . Neuron 55 , 587 - 601 . 10.1016/j.neuron.2007.07.009 Hendricks , M. and Jesuthasan , S. ( 2009 ). PHR regulates growth...
Includes: Supplementary data
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Journal: Development
Development (2022) 149 (21): dev200920.
Published: 7 November 2022
..., but surprisingly P granules are not essential for germ cell fate specification. Here, we describe a second condensate in the C. elegans germ plasm. Like canonical P-bodies found in somatic cells, ‘germline P-bodies’ contain regulators of mRNA decapping and deadenylation and, in addition, the intrinsically...
Includes: Supplementary data
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Journal: Development
Development (2022) 149 (14): dev200545.
Published: 14 July 2022
... a particular challenge in wavelengths occupied by commonly used fluorescent proteins (GFP, mNeonGreen). Stimulated by our work in C. elegans , we describe and validate Spectral Autofluorescence Image Correction By Regression (SAIBR), a simple platform-independent protocol and FIJI plug-in to correct...
Includes: Supplementary data
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Journal Articles
Journal: Development
Development (2021) 148 (19): dev199493.
Published: 28 September 2021
... differentiation are known. Here, we show that the C. elegans Forkhead transcription factor UNC-130 is required in only one of three convergent lineages that produce the same glial cell type. UNC-130 acts transiently as a repressor in progenitors and newly-born terminal cells to allow the proper specification...
Includes: Supplementary data
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Journal: Development
Development (2021) 148 (18): dev199674.
Published: 21 July 2021
... of Caenorhabditis elegans development across multiple larval stages at high-resolution and with minimal effect on physiological development. Microfluidics Imaging Long-term C. elegans Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung http://dx.doi.org/10.13039...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (11): dev199224.
Published: 8 June 2021
... or radially symmetric class members display such lineage convergence. We show here that the C. elegans Atonal homolog lin-32 is differentially expressed in neuronal lineages that give rise to left/right or radially symmetric class members. Loss of lin-32 results in the selective loss of the expression of pan...
Includes: Supplementary data
Journal Articles
Journal: Development
Series: REVIEW COMMONS TRANSFER
Development (2021) 148 (5): dev196949.
Published: 5 March 2021
... following starvation at hatching. The mean position is displaced upon a temperature shift. Finally, highly significant variation was found among C. elegans wild isolates. Overall, this study reveals that the final position of these neurons is quite robust to stochastic variation, shows some sensitivity...
Includes: Supplementary data
Journal Articles