...Laura L. Thomas; Devavrat M. Bodas; Geraldine C. Seydoux Condensates that accumulate small RNA biogenesis factors (nuage) are common in germ cells and often associate with nuclei. In the C. elegans germline, P granules overlay large clusters of nuclear pores and this organization has been proposed...

... between an atypical E2F family member and NLK during C. elegans asymmetric cell division, which may be conserved in other animals. Author for correspondence ( [email protected] ) Handling Editor: Swathi Arur Competing interests The authors declare no competing or financial...

... in any medium provided that the original work is properly attributed. Summary: Proper electrical coupling can be achieved by either partner cell, but each cell's influence on neural circuits may differ. Gap junction CFI-1/ARID3 Transcription factor Neural circuitry C. elegans...

..., but the downstream mechanisms that promote the outgrowth of biological tubes are not well characterized. We show that the conserved kinase MRCK-1 and its substrate the regulatory light chain of non-muscle myosin, MLC-4, are required for outgrowth of the unicellular excretory canal in C. elegans . Ablation of MRCK-1...

... years after their initial discovery in flies and vertebrates, positional cloning and sequence-based searches showed that C. elegans contains HOX cluster genes, an apparent surprise given the simplicity and non-segmented body plan of the nematode, as well as many other non-clustered homeobox genes of all...

... the DTC and germ cells and/or the DTC and basement membrane promote DTC elaboration in conjunction with SAX-7 and HMR-1. We have shown that the dramatic morphological changes in the C. elegans hermaphrodite DTC occur within, and are subject to, the dynamic environment of niche-stem cell...

... , D. , Banerjee , N. , Oliver , D. , Lambert , C. M. and Francis , M. M. ( 2017 ). Excitatory neurons sculpt GABAergic neuronal connectivity in the C. elegans motor circuit . Development 144 , 1807 - 1819 . 10.1242/dev.141911 Bifsha , P. , Balsalobre...

... but is not essential to regulate mRNA translation or stability. Our findings suggest that only a minority of germ granule-associated transcripts contribute to germ cell fate in C. elegans and that the vast majority function as non-specific scaffolds for MEG-3. * Author for correspondence ( [email protected]...

... Coordination C. elegans National Science Foundation http://dx.doi.org/10.13039/100000001 IOS-1755244 National Institutes of Health http://dx.doi.org/10.13039/100000002 R01GM126125 ‘Life is what happens to us while we are making other plans.’ Allen Saunders (popularized...

... gene, a powerful regulator of aging. The homologous mutation in the human insulin receptor causes Donohue syndrome, establishing these mutant worms as an invertebrate model of this disease. Captopril functions in C. elegans by inhibiting ACN-1, the worm homolog of ACE. Reducing the activity of acn-1...

.../bhl.title.4801 Cordes , S. , Frank , C. A. and Garriga , G. ( 2006 ). The C. elegans MELK ortholog PIG-1 regulates cell size asymmetry and daughter cell fate in asymmetric neuroblast divisions . Development 133 , 2747 - 2756 . 10.1242/dev.02447 Doe , C. Q. , Chu...

... are required for fertility in C. elegans and contribute to repression of X-linked genes in the germline. HDAC SIN3 X chromosome C. elegans Germline Proteomics Agence Nationale de la Recherche http://dx.doi.org/10.13039/501100001665 19-CE12-0025-01 Centre National de la...

...Jimei Xu; Yanwen Jiang; Ryan Sherrard; Kyoko Ikegami; Barbara Conradt ABSTRACT During C. elegans development, 1090 somatic cells are generated, of which 959 survive and 131 die, many through apoptosis. We present evidence that PUF-8, a C. elegans ortholog of the mammalian RNA-binding proteins PUM1...

... work is properly attributed. Summary: The kinesin-1 heavy chain promotes the localization and motility of the NEKL-3 kinase in axons. This process is required for axon targeting and its disruption may cause neurodevelopmental disorders. Axon guidance Axon transport C. elegans Kinesin...

... build a new apical extracellular matrix (aECM) beneath a previously built aECM that is subsequently shed. The nuclear hormone receptor NHR-23 (also known as NR1F1) is an important regulator of C. elegans molting. NHR-23 expression oscillates in the epidermal epithelium, and soma-specific NHR-23...

... spermatheca of C. elegans . Development 131 , 2865 - 2874 . 10.1242/dev.01146 Audhya , A. , Hyndman , F. , McLeod , I. X. , Maddox , A. S. , Yates , J. R. , III , Desai , A. and Oegema , K. ( 2005 ). A complex containing the Sm protein CAR-1 and the RNA helicase...

... of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/4.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Summary: In C. elegans , erm-1 mRNA localization to plasma membranes requires...

..., but surprisingly P granules are not essential for germ cell fate specification. Here, we describe a second condensate in the C. elegans germ plasm. Like canonical P-bodies found in somatic cells, ‘germline P-bodies’ contain regulators of mRNA decapping and deadenylation and, in addition, the intrinsically...

... to an EGF patterning signal. C. elegans EGFR ERK Ras Dauer Vulva National Institute of General Medical Sciences http://dx.doi.org/10.13039/100000057 R35GM131746 T32GM008798 F31GM126741 Caenorhabditis elegans larvae display remarkable developmental plasticity...

...-1 M domain during C. elegans embryonic morphogenesis. SrGAP α-Catenin Cadherin complex C. elegans Morphogenesis Cell-cell adhesion National Institute of General Medical Sciences http://dx.doi.org/10.13039/100000057 R01GM058038 R35GM145312 R01GM127687 Howard...