... demonstrate that Met mediates JH effects on the expression of the ecdysteroid-response gene Broad-Complex ( BR-C ). Using RNAi and a classical mutant, we show that Tribolium BR-C is necessary for differentiation of pupal characters. Furthermore, heterochronic combinations of retarded and accelerated...

[email protected] ) 6 2 2007 © 2007. 2007 Drosophila melanogaster Drosophila virilis rhomboid mirror gurken Broad-Complex EGFR signaling cis-regulatory element trans-regulatory landscape Evolution Eggshell Dorsal appendage Evolutionary changes in gene regulation...

... function as a developmental timer coordinating development within the imaginal disc. * Author for correspondence (e-mail: [email protected] ) 19 9 2005 ©2005. 2005 Ultraspiracle Ecdysone receptor Broad-complex Timing of differentiation Imaginal discs...

...Nathalie Renault; Kirst King-Jones; Michael Lehmann Drosophila development is coordinated by pulses of the steroid hormone 20-hydroxyecdysone (20E). During metamorphosis, the 20E-inducible Broad-Complex ( BR-C ) gene plays a key role in the genetic hierarchies that transduce the hormone signal...

... of Drosophila shows that in the absence of USP, early hormone responsive genes such as EcR, DHR3 and E75B fail to up-regulate in response to 20E, but other genes that are normally expressed later, such as β -Ftz-F1 and the Z1 isoform of the Broad-Complex ( BRC-Z1) , are expressed precociously. Sensory neuron...

... Deng W.-M. and Bownes , M. ( 1997 ). Two signaling pathways specify localized expression of the Broad-Complex in Drosophila eggshell patterning and morphogenesis . Development 124 , 4639 – 4647 . 10.1242/dev.124.22.4639 Ephrussi , A. , Dickinson , L. K...

... of the ecdysone signal in vivo with the ecdysoneless 1 ( ecd 1 ) mutant and of ecdysone response with a Broad-Complex mutant result in disruption of morphogenetic furrow progression. In addition, we show that ecdysone-dependent gene expression, both of a reporter of transcriptional activity of the Ecdysone...

...Wu-Min Deng; Mary Bownes ABSTRACT The Drosophila eggshell, which has a pair of chorionic appendages (dorsal appendages) located asymmetrically along both the anterior/posterior and dorsal/ventral axes, provides a good model to study signal instructed morphogenesis. We show that the Broad-Complex...

...Ivette F. Emery; Vahe Bedian; Gregory M. Guild ABSTRACT The steroid hormone ecdysone initiates metamorphosis in Drosophila melanogaster by activating a cascade of gene activity that includes primary response transcriptional regulators and secondary response structural genes. The Broad-Complex ( BR...