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Development (2009) 136 (11): 1859–1868.
Published: 01 June 2009
...Jeremy N. Pulvers; Wieland B. Huttner The extent of apoptosis of neural progenitors is known to influence the size of the cerebral cortex. Mouse embryos lacking Brca1 , the ortholog of the human breast cancer susceptibility gene BRCA1 , show apoptosis in the neural tube, but the consequences...
Includes: Supplementary data
Development (2003) 130 (9): 2001–2012.
Published: 01 May 2003
...Xiaoling Xu; Olga Aprelikova; Peter Moens; Chu-Xia Deng; Priscilla A. Furth Breast tumor suppressor gene 1 ( BRCA1 ) plays an essential role in maintaining genomic integrity. Here we show that mouse Brca1 is required for DNA-damage repair and crossing-over during spermatogenesis. Male Brca1 Δ11/Δ11...