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Keywords: Branching morphogenesis
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Journal Articles
Journal: Development
Development (2023) 150 (6): dev201293.
Published: 20 March 2023
... coordinately in regulating branching. Strikingly, branching morphogenesis in double knockouts is restored by Fgfr1 and Fgfr2 ( Fgfr1/2 ) knock-in alleles incapable of engaging canonical RTK signaling, suggesting that additional FGF-dependent mechanisms play a role in salivary gland branching. Fgfr1/2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (1): dev197657.
Published: 6 January 2022
... described individually, this Review discusses exocrine gland structure-function relationships, highlighting similarities and differences for various exocrine glands present throughout the human body. Exocrine glands Branching morphogenesis Lacrimal glands Mammary glands Salivary glands Structure...
Journal Articles
Journal: Development
Development (2021) 148 (23): dev199544.
Published: 2 December 2021
..., it identifies a mechanism involving RTK signaling and cell proliferative activity at the branch tip for branching morphogenesis that is apparently conserved across the animal kingdom. In the present study of tentacle branch formation using C. pacificum , it was shown that I-cells accumulate in the branch bud...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (10): dev199460.
Published: 20 May 2021
... in early lung development ( Fig. S3B ). Additionally, given the changes in branching morphogenesis in our Wt1 −/− lungs, we examined other specific hallmark genes of lung development, including some related to Fgf9 expression ( Fgfr2iiic , Fgf10 , Fgfr2iiib ), along with a gene known to be expressed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (9): dev199386.
Published: 29 April 2021
...Adam Packard; William H. Klein; Frank Costantini ABSTRACT Ret signaling promotes branching morphogenesis during kidney development, but the underlying cellular mechanisms remain unclear. While Ret -expressing progenitor cells proliferate at the ureteric bud tips, some of these cells exit the tips...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (6): dev190785.
Published: 23 March 2021
..., the exact role of actomyosin contractility in force transmission and the related transcriptional changes during morphogenesis are not fully understood. Here, we report a mechanogenetic role of the actomyosin complex in branching morphogenesis using an organotypic culture system of mouse embryonic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (23): dev185306.
Published: 2 December 2019
... of mammary epithelium. Our results demonstrate a pleiotropic role for FGF signaling in mammary fibroblasts, with implications for regulation of mammary stromal functions and epithelial branching morphogenesis. * Author for correspondence ( [email protected] ) Competing interests The authors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (9): dev175810.
Published: 1 May 2019
... shuttling is largely dispensable in epithelial progenitors for both branching morphogenesis and sacculation. However, if maintained transcriptionally active in airways, nuclear Yap profoundly alters proximal-distal identity and halts epithelial differentiation. Taken together, these observations provide...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (24): 4704–4719.
Published: 15 December 2017
...://www.biologists.com/user-licence-1-1/ Summary: High-resolution analyses during ureteric bud branching reveal that HNFB1 is required for maintaining cell-cell contacts, for proper epithelial cell organization and for further differentiation of the collecting duct system. Kidney Branching morphogenesis...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2017) 144 (16): 2961–2968.
Published: 15 August 2017
... elongation during Drosophila tracheal development mechanistically resembles MyoII-independent collective cell migration; tensile forces resulting from tip cell migration are reduced by cell elongation and passive stalk cell intercalation. Branching morphogenesis Cell intercalation Cell migration...
Includes: Supplementary data
Journal Articles
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Reproductive biology
Journal: Development
Development (2017) 144 (13): 2469–2479.
Published: 1 July 2017
... gross defects in chorioallantoic branching morphogenesis and placental vascular patterning. Microangiography and 3D imaging revealed patchy perfusion of Egfl7 −/− placentas marked by impeded blood conductance through sites of narrowed vessels. Consistent with poor feto-placental perfusion, Egfl7...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2017) 144 (12): 2294–2305.
Published: 15 June 2017
...Lemonia Chatzeli; Marcia Gaete; Abigail S. Tucker Salivary glands are formed by branching morphogenesis with epithelial progenitors forming a network of ducts and acini (secretory cells). During this process, epithelial progenitors specialise into distal (tips of the gland) and proximal (the stalk...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2016) 143 (6): 983–993.
Published: 15 March 2016
...Robert J. Huebner; Neil M. Neumann; Andrew J. Ewald Mammary branching morphogenesis is regulated by receptor tyrosine kinases (RTKs). We sought to determine how these RTK signals alter proliferation and migration to accomplish tube elongation in mouse. Both behaviors occur but it has been difficult...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (18): 3239–3251.
Published: 15 September 2015
... to quantify the regenerative potential of human mammary cells. Mammary stem cell Primary human mammary epithelial cells Basal Luminal Progenitor cells Branching morphogenesis Organoid Regenerative potential CD10 Terminal ductal-lobular units Collagen gel The mammary gland (MG) develops...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (6): 1180–1192.
Published: 15 March 2015
... together, our results demonstrate that Hdac1 and Hdac2 play a crucial role in maintaining essential ureteric genes for renal growth and differentiation. The canonical Wnt signaling pathway controls both UB branching morphogenesis and nephrogenesis. Specifically, Wnt7b is expressed in the UB trunk...
Includes: Supplementary data