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Keywords: Brain tumor
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Journal Articles
Journal: Development
Development (2014) 141 (1): 51–62.
Published: 01 January 2014
... requires an efficient mechanism to rapidly extinguish the activity of self-renewal factors, but the mechanisms remain unknown in most stem cell lineages. During asymmetric division of a type II neural stem cell (neuroblast) in the Drosophila larval brain, the Brain tumor (Brat) protein segregates unequally...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (15): 2670–2680.
Published: 01 August 2012
... type II neuroblasts but is undetectable in immature INPs. Misexpression of klu triggers immature INPs to revert to type II neuroblasts. In larval brains lacking brain tumor function or exhibiting constitutively activated Notch signaling, removal of klu function prevents the reversion of immature INPs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (14): 2639–2648.
Published: 15 July 2006
... development. Here we use mosaic analysis with a repressible cell marker (MARCM) to study the role of the brain tumor ( brat ) gene in neural proliferation control and tumour suppression in postembryonic brain development of Drosophila . Our findings indicate that overproliferation in brat mutants is due to...
Journal Articles
Journal: Development
Development (2005) 132 (10): 2425–2439.
Published: 15 May 2005
...Trudy G. Oliver; Tracy Ann Read; Jessica D. Kessler; Anriada Mehmeti; Jonathan F. Wells; Trang T. T. Huynh; Simon M. Lin; Robert J. Wechsler-Reya Medulloblastoma is the most common malignant brain tumor in children. It is thought to result from the transformation of granule cell precursors (GCPs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (2): 399–407.
Published: 15 January 2002
... indicate that the Drosophila melanogaster tumor suppressor brain tumor ( brat ) is an inhibitor of cell growth and is a functional homolog of the C. elegans gene ncl-1 . The brat gene is able to rescue the large nucleolus phenotype of ncl-1 mutants. We also show that brat mutant cells are larger, have...